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Adoptive immunotherapy after HLA mismatched stem cell transplantation Oosten, L.E.M.

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Adoptive immunotherapy after HLA mismatched stem cell

transplantation

Oosten, L.E.M.

Citation

Oosten, L. E. M. (2007, November 21). Adoptive immunotherapy after HLA

mismatched stem cell transplantation. Retrieved from

https://hdl.handle.net/1887/12446

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral

thesis in the Institutional Repository of the University

of Leiden

Downloaded from: https://hdl.handle.net/1887/12446

Note: To cite this publication please use the final published version (if

applicable).

(2)

Contents

Chapter 1:

General introduction 7

Chapter 2:

Artifi cial antigen-presenting constructs effi ciently stimulate minor 35 histocompatibility antigen-specifi c cytotoxic T lymphocytes

Chapter 3:

TAP-inhibiting proteins US6, ICP47, and UL49.5 affect target cell 45 recognition by minor histocompatibility antigen-specifi c and

alloHLA-specifi c cytotoxic T lymphocytes

Chapter 4:

Investigation of peptide involvement in T cell allorecognition using 61 recombinant HLA class I multimers

Chapter 5:

Promiscuity of the alloHLA-A2-restricted T cell repertoire hampers 81 the generation of minor histocompatibility antigen-specifi c cytotoxic

T cells across HLA barriers

Chapter 6:

General discussion 101

Summary 123

Nederlandse samenvatting voor niet-immunologen 129

Abbreviations 139

Curriculum Vitae 141

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