Molecular analysis of the HPJ-JT syndrome and sporadic parathyroid carcinogenesis Haven, C.J.

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A MLPA probe set (Table 1) was constructed based on the following three criteria: a) the inclusion of genomic regions previously implicated in parathyroid tumorigenesis in

As the majority of parathyroid carcinomas with aggressive behaviour carry HRPT2 mutations, somatic DNA sequence analysis of this gene in tumours is a valid approach for the

These results again confirmed the role of HRPT2 in sporadic parathyroid cancer formation, but also showed parathyroid carcinomas with MEN1 mutations possibly suggesting that an

A, diffuse staining (primary parathyroid hyperplasia); B, diffuse staining (sporadic adenoma with a rim of normal tissue); C, focal loss (parathyroid carcinoma); and D, diffuse

Peripheral blood cells were stained with HLA-A2.1 tetramers containing the tyrosinase368–376 peptide followed by staining with a panel of lineage antibodies, as described in

Blades and blade fragments seem to have been especially used for longitudinal motions, mainly on plant material (7/12). Flake and flake fragments are used in different motions on

This shape also occurs in the combination artefacts (see below). The shape is the result of intensive use in a repetitive abrasive motion, carried out from different angles. In