Hereditary paragangliomas : clinical characteristics and genotype- phenotype associations
Havekes, B.
Citation
Havekes, B. (2008, December 11). Hereditary paragangliomas : clinical characteristics and genotype-phenotype associations. Retrieved from https://hdl.handle.net/1887/13397
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13397
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Stellingen
Behorende bij het proefschrift Hereditary Paragangliomas
1. Although most paragangliomas are benign, their chronic nature and their localization in close proximity with nerves and vasculature may result in considerable morbidity.
Dit proefschrift
2. Clinical studies of genotype-phenotype associations can be contributory to the development of new ideas regarding the pathogenesis of paraganglioma syndromes.
Dit proefschrift
3. The ‘million-dollar’ question remains to be elucidated, why the germline mutations, that are in fact present throughout the whole body, selectively lead to paraganglioma syndromes. Dit proefschrift
4. The possibility of undetected ‘non-secreting’ paragangliomas in SDHD carriers might lead to future guidelines with imaging studies as primary investigation. Dit proefschrift 5. Mediastinal paragangliomas are associated with SDHB and SDHD gene mutations and
most often have a noradrenergic phenotype and aggressive behavior. Dit proefschrift 6. The diagnosis of a functioning glomus tumor is first based on a suspicion of its presence.
Eschun et al. Am J Hypertens. 1998 Feb;11(2):258-62.
7. In the Netherlands, head-and-neck paragangliomas must be considered hereditary until proven otherwise.
Proefschrift Jeroen Jansen, Leiden, 2001
8. If your result needs a statistician, you should design a better experiment.
Ernest Rutherford (1871-1937)
9. After he got a Ph.D., his mother took to introducing him as "a doctor, but not the kind who helps people.”
Randy Pausch (1960-2008)
10. A publication in the automotive magazine Autoweek may actually have a higher impact than a manuscript published in the well-respected Dutch medical journal Nederlands Tijdschrift voor Geneeskunde. Persoonlijke ervaring
11. Few people are capable of expressing with equanimity opinions which differ from the prejudices of their social environment. Most people are even incapable of forming such opinions. Albert Einstein (1879-1955)
12. What Washington needs is adult supervision.
Barack Obama
Bastiaan Havekes, Leiden, 11 december 2008
