Cover Page The handle http://hdl.handle.net/1887/138667

The handle http://hdl.handle.net/1887/138667 holds various files of this Leiden University

dissertation.

Author:

Kerkhof, M.

Title: Antiepileptic and antitumor treatment in brain tumor patients: Impact on clinical

and radiological treatment

ANTIEPILEPTIC AND

ANTITUMOR TREATMENT

IN BRAIN TUMOR PATIENTS:

IMPACT ON CLINICAL AND

RADIOLOGICAL OUTCOME

ANTIEPILEPTIC AND

ANTITUMOR TREATMENT

IN BRAIN TUMOR PATIENTS:

IMPACT ON CLINICAL AND

RADIOLOGICAL OUTCOME

Proefschrift

ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr C.J.J.M. Stolker, volgens besluit van het College voor Promoties te verdedigen op

dinsdag 15 december 2020 klokke 11.15 uur

door

Melissa Kerkhof

geboren te Zwijndrecht in 1985

Dr. L. Dirven

Table of contents

Part I: The role of antiepileptic treatment in relation to clinical and radiological outcome

2 Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme

3 Withdrawal of antiepileptic drugs in patients with low grade and anaplastic glioma after long-term seizure freedom: a prospective observational study

Part II: The impact of antitumor treatment on clinical and radiological outcome

4 Interobserver variability in the radiological assessment of MR imaging including perfusion MRI in glioblastoma multiforme

5 Visual inspection of MR rCBV maps has limited value for distinguishing progression from pseudoprogression in GBM patients

6 Clinical applicability of and changes in perfusion MR imaging in brain metastases after stereotactic radiotherapy

7 Summary, general discussion and future perspectives Appendix

Samenvatting (Summary in Dutch) List of publications

Dankwoord (Acknowledgements in Dutch) About the author

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