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Methods: All PCs ordered for patients in the haematology ward were provided with an evaluation form. Clinical parame- ters, laboratory results and patient reactions before and after transfusion were recorded.

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Introduction: Starting november 2001 all platelet concentrates (PCs) prepared by the regional Sanquin bloodbanks are tested bacteriologically. As a result all PCs were delivered with a negative culture screen. Without culture screen, the reported incidence of febrile reactions after transfusion of PCs is approximately 4,5%

1

. Within the framework of haemovigi- lance, we evaluated the incidence of febrile reactions and the accompanying pitfalls after PCs transfusion.

Methods: All PCs ordered for patients in the haematology ward were provided with an evaluation form. Clinical parame- ters, laboratory results and patient reactions before and after transfusion were recorded.

Results and discussion: Adverse effects in 31 patients (M/F:

20/11) following 212 transfusions were evaluated. Incidence of transfusion reactions: Fever (>1°C): 0,5%; Rash: 1,4% and Urticaria 0,9%. We also observed a drop in systolic blood

pressure (>20 mm Hg): 6,1%. The mean platelet increment after 1h was 14,6 ± 13,3 (±SD 10

9

/l). Compared with results in literature there is a considerable decrease in febrile reactions.

This might be related to the delivery of PCs with a negative culture screen. Nursing staff did recording of data without any problems.

Conclusion: Bacteriological screening of PCs may decrease the incidence of febrile reactions after transfusion.

Referentie

Wildt-Eggen J de, Nauta S, Schrijver JG, Marwijk Kooy M van, Bins M, Prooijen HC van. Reactions and platelet incre- ments after transfusion of platelet concentrates in plasma or an additive solution: a prospective, randomized study. Transfu- sion. 2000; 40: 398-403.

234 Ned Tijdschr Klin Chem 2002, vol. 27, no. 5

Ned Tijdschr Klin Chem 2002; 27: 234

Abstract

Reactions and platelet increments after transfusion of platelet concentrates

A. HUISMAN

1

, W.W. van SOLINGE

1

and H.C. van PROOIJEN

1,2

University Medical Center, Department of Clinical Chemistry

1

and Department of Haematology

2

, Utrecht

Door een omissie is dit abstract niet in het maartnummer gepubliceerd.

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