On connectivity in the central nervous systeem : a magnetic resonance imaging study
Stieltjes, B.
Citation
Stieltjes, B. (2011, December 6). On connectivity in the central nervous systeem : a magnetic resonance imaging study.
Retrieved from https://hdl.handle.net/1887/18190
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On connectivity in the central nervous system
a magnetic resonance imaging study
On connectivity in the central nervous system a magnetic resonance imaging study
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. Mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 6 december 2011
klokke 16.15 uur door Bram Stieltjes geboren te Ede
in 1974
promotiecommissie
Promotores
Prof. Dr. M.A.van Buchem
Prof. Dr. M. Essig, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Overige leden
Prof. Dr. S. Mori, Johns Hopkins University, Baltimore, usa Prof. dr. A. Webb
Dr. ir. M.J.P. van Osch Mw. Dr. L. van der Weerd
© B. Stieltjes
All rights preserved. No parts of this publication may be reproduced or transmitted in any form or by any means without prior written permission of the author.
Grafisch ontwerp Leonie Verbrugge, Keper ontwerp, Rosmalen Drukwerk Biblo van Gerwen, ’s-Hertogenbosch
Contents
1 Introduction and aims . . . .7
2 Diffusion Tensor Imaging and Axonal Tracking in the Human Brainstem . . . . 15
3 Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking . . . . 41
4 Brain white matter anatomy of tumor patients evaluated with diffusion tensor imaging . . . . 61
5 Detection of tumour infiltration in axonal fibre bundles using diffusion tensor imaging . . . . 73
6 Diffusion tensor imaging in primary brain tumors: reproducible quantitative analysis of corpus callosum infiltration and contralateral involvement using a probabilistic mixture model . . . . 87
7 Diffusion tensor imaging-based fractional anisotropy quantification in the corticospinal tract of patients with amyotrophic lateral sclerosis using a probabilistic mixture model . . . . 115
8 Reproducible evaluation of spinal cord dti using an optimized inner volume sequence in combination with probabilistic roi analysis . . . . 137
9 Manganese Enhanced Magnetic Resonance Imaging in a Contusion Model of Spinal Cord Injury in Rats – correlation with motorfunction . . . . 155
10 Manganese-enhanced magnetic resonance imaging for in vivo assessment of damage and functional improvement following spinal cord injury in mice . . . . 173
11 Summary . . . . 195
12 Nederlandse samenvatting . . . . 203
13 List of publications . . . . 211
14 Curriculum Vitae . . . . 214
