Developmental regulation and evolution of cAMP signalling in Dictyostelium

van der Heijden, volgens besluit van het College voor Promoties te verdedigen op dinsdag 23 oktober 2007 klokke 13.45 uur door.. Elisa Álvarez Curto geboren te Valladolid, Spanje

(2002) cAMP signaling in Dictyostelium : Complexity of cAMP synthesis, degradation and detection. Adenylyl cyclase G is activated by an intramolecular osmosensor. CAR2, a prestalk

Early work showed that extracellular cAMP is both necessary and sufficient for prespore gene induction: micromolar cAMP acting on surface cAMP receptors triggers prespore

Both compounds acted directly on enzyme activity assayed in cell lysates, but only SQ22536 was also a specific inhibitor when added to intact

Treatment of aggregation competent cells with concentrations of adenosine in the millimolar range inhibits the expression of the prespore specific genes psA and cotC

Thus, phylogenetic analyses of two independent molecular markers, SSU rRNA and Į- tubulin, consistently subdivide nearly all dictyostelid species into four major groups with strong

The cAMP binding properties of the DmcAR are similar to those of DdcAR1, and DmcAR fully restores oscillatory signalling and development in a D.discoideum car1car3 mutant..

However, analysis of the developmental regulation of the cAR1 orthologues suggests that extracellular cAMP signalling was originally originated to control fruiting body