Supplementary table S1 Demographics and disease activity measures General
population (n=2323)
RA (n=3898)
PsA
(n=1515) p-value
Age (years), mean (SD) 44.9 (16.5) 55.9 (31.6) 48.1 (12.6) <0.001
Female, n/total (%) 1192/2323
(51.3)
2776/3886 (71.4)
759/1510
(50.3) <0.001 Disease duration (years), median (25th, 75th
percentile) NA 1.9 (0.1, 11.0) 2.0 (0.1, 9.6) 0.97
28 tender joint count, median (25th, 75th percentile)
Baseline NA 6 (3, 11) 4 (2, 8) <0.001
Baseline minus 3 months NA -2 (-6, 0) -1 (-4, 1) <0.001 Baseline minus 6 months NA -3 (-7 ,0) -1 (-4, 0) <0.001 28 swollen joint
count, median (25th, 75th percentile)
Baseline NA 6 (3, 10) 2 (1, 5) <0.001
Baseline minus 3 months NA -2 (-6, 0) -1 (-3, 0) <0.001 Baseline minus 6 months NA -3 (-6, 0) 1 (-3.75, 0) <0.001 Patient’s global
assessment, mean (SD)
Baseline NA 49.7 (24.2) 51.0 (22.6) 0.05
Baseline minus 3 months NA -14.6 (27.1) -14.7 (23.3) 0.89 Baseline minus 6 months NA -14.8 (27.5) -16.6 (26.6) 0.08 Evaluator’s
global assessment, mean (SD)
Baseline NA 39.6 (18.8) 33.5 (16.3) <0.001
Baseline minus 3 months NA -15.8 (20.5) -13.6 (19.1) 0.001 Baseline minus 6 months NA -18.9 (21.8) -16.3 (19.8) <0.001
DAS28, mean (SD)
Baseline NA 4.9 (1.4) 4.2 (1.3) <0.001
Baseline minus 3 months NA -1.1 (1.5) -0.9 (1.2) <0.001 Baseline minus 6 months NA -1.4 (1.5) -1.2 (1.3) <0.001
SDAI, mean (SD)
Baseline NA 25.8 (13.8) 19.2 (10.4) <0.001
Baseline minus 3 months NA -10.1 (13.8) -6.2 (11.4) <0.001 Baseline minus 6 months NA -12.1 (14.6) -8.0 (10.4) <0.001
CDAI, mean (SD)
Baseline NA 23.5 (13.0) 17.6 (9.9) <0.001
Baseline minus 3 months NA -9.2 (12.9) -5.7 (10.6) <0.001 Baseline minus 6 months NA -11.0 (13.6) -7.3 (9.8) <0.001 CDAI, clinical disease activity index; DAS28, 28-joint Disease Activity Score with erythrocyte
sedimentation rate; NA, non-applicable; PsA, psoriatic arthritis; RA, rheumatoid arthritis; SDAI, simplified disease activity index
Supplementary table S2 Unadjusted means (ANOVA) and estimated marginal means (ANCOVA) adjusted for age and gender of SF-36 component summaries, norm-based scale scores and SF-6D utility scores at 3 and 6 months follow-up
3 months Component
summary/ scale score
Unadjusted analyses, mean (SD)
p-value Estimated marginal means (95%CI)
p-value
RA PsA RA PsA
PCS 34.4 (11.1) 35.1 (10.8) 0.06 36.4 (36.0-36.8) 36.1 (35.5-36.8) 0.55 MCS 48.8 (10.8) 48.9 (11.2) 0.92 48.2 (47.8-48.6) 48.0 (47.4-48.6) 0.60
SF-6D 0.61 (0.10) 0.61 (0.20) 0.42 0.62 (0.61-0.62) 0.61 (0.60-0.62) 0.04
Physical Functioning 32.3 (14.9) 34.9 (14.1) <0.001 33.4 (32.9-34.0) 34.5 (33.7-35.4) 0.03 Role Physical 37.1 (11.2) 38.2 (11.4) 0.003 37.5 (37.1-37.9) 38.1 (37.4-38.7) 0.16 Bodily Pain 39.2 (8.8) 38.8 (8.5) 0.13 39.6 (39.3-39.9) 38.7 (38.2-39.2) 0.003 General Health 39.0 (9.9) 38.5 (10.2) 0.16 39.3 (38.9-39.7) 38.5 (37.9-39.0) 0.02 Vitality 43.3 (10.6) 42.5 (10.4) 0.03 44.0 (43.6-44.4) 42.5 (41.9-43.1) <0.001 Social Functioning 42.9 (11.8) 43.1 (11.8) 0.59 43.4 (43.0-43.9) 43.0 (42.3-43.7) 0.30 Role Emotional 42.8 (13.1) 44.2 (12.9) 0.002 42.9 (42.4-43.4) 43.9 (43.2-44.6) 0.03 Mental Health 46.9 (10.9) 46.9 (10.7) 0.89 47.4 (47.0-47.8) 46.8 (46.2-47.4) 0.15
6 months Component
summary/ scale score
Unadjusted analyses, mean (SD)
p-value Estimated marginal means (95%CI)
p-value
RA PsA RA PsA
PCS 35.5 (11.2) 36.1 (10.8) 0.16 36.3 (35.9-36.8) 35.9 (35.2-36.6) 0.30
MCS 49.6 (10.6) 49.5 (10.7) 0.76 50.1 (49.6-50.5) 49.5 (48.8-50.1) 0.14
SF-6D 0.62 (0.10) 0.62 (0.10) 0.92 0.62 (0.62-0.63) 0.62 (0.61-0.63) 0.33
Physical Functioning 33.9 (15.0) 36.7 (13.6) <0.001 35.1 (34.6-35.7) 36.3 (35.5-37.2) 0.03 Role Physical 38.6 (11.7) 39.7 (11.7) 0.01 39.2 (38.7-39.7) 39.5 (38.8-40.2) 0.50 Bodily Pain 40.1 (9.0) 39.7 (8.7) 0.14 40.6 (40.3-41.0) 39.6 (39.0-40.1) 0.001 General Health 39.6 (10.1) 38.7 (10.2) 0.02 39.9 (39.5-40.3) 38.6 (38.0-39.2) 0.001 Vitality 44.2 (10.8) 43.5 (11.1) 0.06 45.1 (44.7-45.5) 43.5 (42.8-44.1) <0.001 Social Functioning 44.1 (11.5) 44.3 (11.2) 0.68 44.8 (44.4-45.3) 44.2 (43.5-44.9) 0.12 Role Emotional 43.8 (13.0) 45.0 (12.5) 0.007 44.1 (43.6-44.7) 44.8 (44.0-45.6) 0.16 Mental Health 47.8 (10.7) 47.7 (10.5) 0.78 48.4 (48.0-48.9) 47.6 (47.0-48.3) 0.05
PCS, Physical Component Summary; MCS, Mental Component Summary; PsA, psoriatic arthritis; RA, rheumatoid arthritis; SF-6D, short form-6 dimensions utility scores
Supplementary table S3 Unadjusted means (ANOVA analyses) and estimated marginal means (ANCOVA analyses) adjusted for age and gender (comparisons with the general population) and the respective 28-joint disease activity scores (comparisons between rheumatoid and psoriatic arthritis patients) of SF-36 component summaries, norm-based scale scores and SF-6D utility scores
Baseline
Component summary/ scale score
Unadjusted analyses, mean (SD)
p-value
Estimated marginal means (95%CI)
p-value General
population RA PsA General
population RA PsA
PCS 50.0 (10.1) 29.7 (9.9) 30.5 (9.5) <0.0011,2 0.023
49.7 (49.2-50.1)
30.6 (30.3-30.9)
28.8
(28.3-29.3) <0.0011,2,3 MCS 50.0 (10.2) 46.8 (11.3) 47.1 (11.4) <0.0011,2
0.593
50.0 (49.5-50.5)
47.3 (46.9-47.7)
46.5 (45.9-47.1)
<0.0011,2 0.043 SF-6D 0.80 (0.14) 0.60 (0.12) 0.61 (0.12) <0.0011,2
0.173
0.80 (0.80-0.81)
0.61 (0.61-0.61)
0.59
(0.58-0.59) <0.0011,2,3 Physical Functioning 49.4 (10.8) 27.7 (14.5) 30.5 (13.5) <0.0011,2,3 48.9
(48.3-49.4)
29.2 (28.7-29.6)
27.8 (27.1-28.5)
<0.0011,2 0.0013 Role Physical 49.6 (10.3) 32.9 (9.1) 34.0 (9.9) <0.0011,2
0.0013
49.4 (49.0-49.8)
33.5 (33.2-33.8)
32.9 (32.4-33.4)
<0.0011,2 0.043 Bodily Pain 49.6 (10.3) 33.5 (7.5) 33.6 (7.2) <0.0011,2
0.963
49.4 (49.1-49.8)
34.0 (33.8-34.2)
32.3
(32.0-32.7) <0.0011,2,3 General Health 49.6 (10.3) 37.5 (9.5) 36.8 (9.7) <0.0011,2
0.023
49.5 (49.0-49.9)
38.0 (37.6-38.3)
36.0
(35.5-36.5) <0.0011,2,3 Vitality 49.8 (10.3) 39.6 (10.1) 39.3 (10.3) <0.0011,2
0.693
49.9 (49.5-50.3)
40.7 (40.4-41.0)
38.5
(38.0-39.0) <0.0011,2,3 Social Functioning 49.5 (10.5) 39.1 (12.6) 39.5 (12.3) <0.0011,2
0.593
49.4 (48.9-49.9)
40.1 (39.6-40.5)
38.1
(37.4-38.7) <0.0011,2,3 Role Emotional 49.8 (10.2) 40.2 (13.6) 41.6 (13.6) <0.0011,2
0.0023
49.5 (49.0-50.0)
40.7 (40.2-41.2)
40.4 (39.6-41.1)
<0.0011,2 0.483 Mental Health 49.8 (10.3) 44.3 (11.5) 44.7 (11.1) <0.0011,2
0.633
49.8 (49.4-50.3)
45.1 (44.7-45.5)
43.9 (43.3-44.6)
<0.0011,2 0.0033 3 months
Component summary/ domain
score
Unadjusted analyses, mean (SD)
p-value Estimated marginal means (95%CI)
p-value
RA PsA RA PsA
PCS 34.4 (11.1) 35.1 (10.8) 0.06 35.0 (34.7-35.4) 33.4 (32.8-34.0) <0.001
MCS 48.8 (10.8) 48.9 (11.2) 0.92 49.0 (48.5-49.4) 48.7 (48.0-49.4) 0.48
SF-6D 0.61 (0.10) 0.61 (0.20) 0.42 0.62 (0.61-0.62) 0.60 (0.59-0.61) <0.001 Physical Functioning 32.3 (14.9) 34.9 (14.1) <0.001 33.3 (32.8-33.8)) 32.7 (31.9-33.5) 0.19 Role Physical 37.1 (11.2) 38.2 (11.4) 0.003 37.5 (37.1-37.9) 37.1 (36.5-37.8) 0.35 Bodily Pain 39.2 (8.8) 38.8 (8.5) 0.13 39.6 (39.3-39.9) 37.6 (37.2-38.0) <0.001 General Health 39.0 (9.9) 38.5 (10.2) 0.16 39.3 (38.9-39.7) 37.6 (37.0-38.1) <0.001 Vitality 43.3 (10.6) 42.5 (10.4) 0.03 43.9 (43.5-44.3) 41.8 (41.2-42.4) <0.001 Social Functioning 42.9 (11.8) 43.1 (11.8) 0.59 43.3 (42.9-43.8) 42.2 (41.5-42.9) 0.007
Role Emotional 42.8 (13.1) 44.2 (12.9) 0.002 43.0 (42.5-43.5) 43.5 (42.7-44.2) 0.31 Mental Health 46.9 (10.9) 46.9 (10.7) 0.89 47.4 (46.9-47.8) 46.4 (45.7-47.0) 0.01
6 months
Component summary/ scale score
Unadjusted analyses, mean (SD)
p-value Estimated marginal means (95%CI)
p-value
RA PsA RA PsA
PCS 35.5 (11.2) 36.1 (10.8) 0.16 36.2 (35.8-36.6) 34.8 (34.2-35.5) <0.001
MCS 49.6 (10.6) 49.5 (10.7) 0.76 50.0 (49.6-50.5) 49.2 (48.5-49.9) 0.05
SF-6D 0.62 (0.10) 0.62 (0.10) 0.92 0.62 (0.62-0.63) 0.61 (0.60-0.62) 0.006
Physical Functioning 33.9 (15.0) 36.7 (13.6) <0.001 34.9 (34.4-35.5) 34.9 (34.1-35.8) 0.99 Role Physical 38.6 (11.7) 39.7 (11.7) 0.01 39.1 (38.7-39.6) 38.7 (38.0-39.4) 0.31 Bodily Pain 40.1 (9.0) 39.7 (8.7) 0.14 40.5 (40.2-40.8) 38.8 (38.3-39.3) <0.001 General Health 39.6 (10.1) 38.7 (10.2) 0.02 39.9 (39.5-40.3) 38.0 (37.3-38.6) <0.001 Vitality 44.2 (10.8) 43.5 (11.1) 0.06 45.1 (44.7-45.5) 42.8 (42.2-43.5) <0.001 Social Functioning 44.1 (11.5) 44.3 (11.2) 0.68 44.7 (44.3-45.2) 43.4 (42.7-44.1) 0.003 Role Emotional 43.8 (13.0) 45.0 (12.5) 0.007 44.0 (43.4-44.5) 44.3 (43.5-45.1) 0.48 Mental Health 47.8 (10.7) 47.7 (10.5) 0.78 48.4 (48.0-48.9) 47.1 (46.4-47.8) 0.002
1General population - RA; 2General population - PsA; 3RA - PsA. MCS, mental component summary;
PCS, physical component summary; PsA, psoriatic arthritis; RA, rheumatoid arthritis; SF-6D, short form-6 dimensions utility scores