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TRPM7, Calcium and the cytoskeleton Langeslag, Michiel

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Citation

Langeslag, M. (2006, October 11). TRPM7, Calcium and the cytoskeleton. Retrieved from

https://hdl.handle.net/1887/4863

Version:

Corrected Publisher’s Version

License:

Licence agreement concerning inclusion of doctoral thesis in the

Institutional Repository of the University of Leiden

Downloaded from:

https://hdl.handle.net/1887/4863

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TRPM7,Calcium andtheCytoskeleton

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TRPM7,CalciumandtheCytoskeleton

PROEFSCHRIFT

ter verkrijging van

de graad van Doctor aan de UniversiteitLeiden, op gezag van de Rector M agnificus Dr.D.D.Breimer,

hoogleraar in de faculteitder W iskunde en Natuurwetenschappen en die der Geneeskunde, volgens besluitvan hetCollege voor Promoties

te verdedigen op 11 oktober 2006 klokke 13.45 uur

door

MichielLangeslag

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Promotor Prof. Dr. W.H. Moolenaar

CoͲpromotor Dr. K. Jalink (Nederlands Kanker Instituut, Amsterdam)

Referent Dr. E.H. Danen

O verigeleden Prof. Dr. J.J. Neefjes

Prof. Dr. T. Schmidt

Dr. F.N. van Leeuwen (NCMLS, Radboud Universiteit, Nijmegen)

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TableofContents

TableofContents

ChapterI

 Introduction 7



ChapterII

 G q/PhospholipaseCͲcoupledAgonistsActivateTRPM 7  ChannelsunderPhysiologicalConditions 41



ChapterIII

 PIP2asaPhysiologicalD eterm inantofTRPM 7ChannelActivity 59



ChapterIV

 TRPM 7,aN ovelRegulatorofActom yosinContractilityand

 CellAdhesion 71

 Supplem entalM aterial 89

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