Calcification and C-reactive protein in atherosclerosis : effects of
calcium blocking and cholesterol lowering therapy
Trion, A.
Citation
Trion, A. (2006, October 5). Calcification and C-reactive protein in atherosclerosis : effects
of calcium blocking and cholesterol lowering therapy. Retrieved from
https://hdl.handle.net/1887/4584
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in theInstitutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/4584
Calcification and C-reactive protein
in atherosclerosis
Effects of calcium blocking and cholesterol lowering
therapy
Calcification and C-reactive protein in
atherosclerosis
Effects of calcium blocking and cholesterol lowering therapy
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Dr. D.D. Breimer,
hoogleraar in de faculteit Wiskunde en Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties te verdedigen op donderdag 5 oktober 2006
klokke 15.00 uur
door
Astrid Trion
Promotiecommissie
Promotores: Prof. dr. A. van der Laarse
Prof. dr. J.W. Jukema
Co-promotores: Dr. J.J. Emeis (TNO-Kwaliteit van Leven, Leiden) Dr. M.P.M. de Maat (Erasmus MC, Rotterdam)
Referent: Prof. dr. G. Pasterkamp (Universitair Medisch Centrum Utrecht)
Overige leden: Prof. dr. E.E. van der Wall Prof. dr. ir. L.M. Havekes Prof. dr. R.E. Poelmann
ISBN-10: 90-6464-030-0 ISBN-13: 978-90-6464-030-8
¤ A. Trion. Leiden, the Netherlands, 2006
“Realize that to question is how we grow”
Heather Small: 'Proud'
____________________________________________________________________________________________________
The research described in this thesis was performed at the Laboratory of Cardiobiochemistry of the Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands, and at the Gaubius Laboratory of TNO Quality of Life, Leiden, the Netherlands.
Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.
The printing of this thesis was also financially supported by the Dr. Ir. van de Laar Stichting.
_____________________________________________________________________________________________________
Contents
Chapter 1 Introduction 9
Chapter 2 Vascular smooth muscle cells and calcification in 29
atherosclerosis
American Heart Journal 2004; 147: 808-814
Chapter 3 In vitro calcification of neonatal vascular smooth muscle 45
cells
Submitted
Chapter 4 Modulation of calcification of vascular smooth muscle cells 63
in culture by calcium antagonists, statins, and their combination
Submitted
Chapter 5 C-reactive protein as a risk factor versus risk marker 83
Current Opinion in Lipidology 2004; 15: 651-657
Chapter 6 No effect of C-reactive protein on early atherosclerosis 99
development in ApoE*3-Leiden/hCRP transgenic mice
ATVB 2005; 25: 1635-1640
Chapter 7 Anti-atherosclerotic effect of amlodipine, alone and in 119
combination with atorvastatin, in ApoE*3-Leiden/hCRP transgenic mice
Journal of Cardiovascular Pharmacology 2006; 47: 89-95
Chapter 8 Summary and general discussion 139
Chapter 9 Samenvatting 145
Abbreviations 151
Nawoord 153
Curriculum Vitae 155
