University of Groningen Modulation of T and B cell function in Granulomatosis with polyangiitis Lintermans, Lucas Leonard

University of Groningen

Modulation of T and B cell function in Granulomatosis with polyangiitis

Lintermans, Lucas Leonard

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Publication date: 2019

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Lintermans, L. L. (2019). Modulation of T and B cell function in Granulomatosis with polyangiitis: Targeting Kv1.3 potassium channels. Rijksuniversiteit Groningen.

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Modulation of T and B cell function in

Granulomatosis with polyangiitis

Targeting Kv1.3 potassium channels

527482-L-bw-Lintermans 527482-L-bw-Lintermans 527482-L-bw-Lintermans 527482-L-bw-Lintermans Processed on: 2-1-2019 Processed on: 2-1-2019 Processed on: 2-1-2019

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Colofon

Layout: Douwe Oppewal Printing: Ipskamp Printing

ISBN: 978-94-034-1345-7 printed version 978-94-034-1344-0 e-book

Cover image: Stichodactyla helianthus by Florent Charpin (reefguide.org)

Copyright © 2018 by L.L. Lintermans. All rights reserved. Any unauthorized reprint or use of this material is prohibited. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without permission of the author or, when appropriate, of the publishers of the publications.

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Modulation of T and B cell function in

Granulomatosis with polyangiitis

Targeting Kv1.3 potassium channels

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

UHFWRUPDJQL¿FXVSURIGU(6WHUNHQ en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op PDDQGDJIHEUXDULRPXXU

door

Lucas Leonard Lintermans JHERUHQRSPDDUW

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Promotores Prof. dr. P. Heeringa Prof. dr. C.A. Stegeman Copromotores Dr. W.H. Abdulahad Dr. A. Rutgers

Beoordelingscommissie Prof. dr. A.L.W. Huckriede Prof. dr. S.P. Berger Prof. dr. B. Wilde

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Paranimfen

Bram Piersma Yannick van Sleen

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Voor mijn drie dames

Charlotte, Eva en Sophie

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TABLE OF CONTENTS

CHAPTER 1

General introduction and outline of the thesis

CHAPTER 2

T cells in vascular inflammatory diseases

Front. Immunol. 5, 504 (2014)

CHAPTER 3

Chemokine receptor co-expression reveals aberrantly

distributed T

effector memory cells in GPA patients

Arthritis Research & Therapy (2017) 19:136

CHAPTER 4

Kv1.3 blockade by ShK186 modulates CD4

_effector

memory T-cell activity of patients with granulomatosis

with polyangiitis in vitro.

Submitted

CHAPTER 5

Kv1.3 channel blockade modulates the effector function

of B cells in granulomatosis with polyangiitis

Front Immunol. 8:1205 (2017)

CHAPTER 6

Circulating

CD24

_CD38

_{regulatory B-cells correlate}

inversely with the frequency of TH

17-cells in

granulomatosis with polyangiitis patients

Accepted for publication; Rheumatology

CHAPTER 7

Summary, general discussion, and future perspectives

CHAPTER 8 Nederlandse

samenvatting

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