University of Groningen
B cells in ANCA-associated vasculitides
von Borstel, Anouk
DOI:
10.33612/diss.93537940
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
von Borstel, A. (2019). B cells in ANCA-associated vasculitides: from pathogenic players to biomarkers. University of Groningen. https://doi.org/10.33612/diss.93537940
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B cells in ANCA-associated Vasculitides
From Pathogenic Players to Biomarkers
The research presented in this thesis was financially supported by:
The printing of this thesis was financially supported by:
Cover Design: Nikki Vermeulen - Ridderprint Lay-out: Nikki Vermeulen - Ridderprint Printing: Ridderprint - www.ridderprint.nl ISBN: 978-94-034-1866-7 (printed version) 978-94-034-1865-0 (electronic version)
B cells in ANCA-associated Vasculitides
From Pathogenic Players to Biomarkers
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
And in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 11 September 2019 at 12:45 hours
by
Anouk von Borstel born on 7 May 1991 in Luzern, Switzerland
Supervisors
Prof. P. Heeringa Prof. C.A. Stegeman
Co-supervisors
Dr. J.S.F. Sanders Dr. W.H. Abdulahad
Assessment Committee
Prof. N.A. Bos Prof. L.B. Hilbrands Prof. J.D. Laman
Paranymphs
Dr. Olaf Perdijk Gerjan Dekkema
Table of Contents
Chapter 1
General Introduction and Aims of this Thesis 9
Chapter 2
Cellular Immune Regulation in the Pathogenesis of ANCA-associated 21
Vasculitides
Chapter 3
Circulating CD24hiCD38hi Regulatory B cells Correlate Inversely with the 39
ThEM17 cell Frequency in Granulomatosis with Polyangiitis Patients
Chapter 4
Evidence for Enhanced Bruton’s Tyrosine Kinase Activity in 55
Transitional and Naïve B cells of Patients with Granulomatosis with Polyangiitis
Chapter 5
Mycophenolic Acid and 6-Mercaptopurine both Inhibit B cell Proliferation in 83
Granulomatosis with Polyangiitis Patients, whereas Only Mycophenolic Acid Inhibits B cell IL-6 Production
Chapter 6
Plasmablast Frequency during Remission Predicts Relapsing Disease in 99
Granulomatosis with Polyangiitis Patients
Chapter 7
Summary, General Discussion and Future Perspectives 115
References 129
Chapter 8
Nederlandse Samenvatting 144
Curriculum Vitae 148
