Sodium and potassium intake as determinants of cardiovascular and renal health
Kieneker, Lyanne Marriët
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Publication date: 2019
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Kieneker, L. M. (2019). Sodium and potassium intake as determinants of cardiovascular and renal health. Rijksuniversiteit Groningen.
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Sodium and potassium intake
as determinants of cardiovascular
and renal health
Groningen, Graduate School of Medical Sciences, the Dutch Kidney Foundation, and the Dutch Heart Foundation for publication of this thesis is gratefully acknowledged.
Financial support for printing of this thesis was also kindly provided by:
ERBE Nederland B.V., ChipSoft B.V., Astellas Pharma B.V., Pfizer B.V. en Noord Negentig accountants en belastingadviseurs.
Lay-out: Thomas van der Vlis, persoonlijkproefschrift.nl Printing: Ridderprint BV – www.ridderprint.nl
ISBN (printed): 978-94-6375-212-1 © 2019, L.M. Kieneker, the Netherlands.
All rights reserved. No parts of this thesis may be reproduced or transmitted in any form, by any means, without prior written permission from the author.
Sodium and potassium intake
as determinants of cardiovascular
and renal health
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 13 februari 2019 om 16.15 uur
door
Lyanne Marriët Kieneker
geboren op 18 mei 1989 te Smallingerland
Dr. M.M. Joosten
Beoordelingscommissie
Prof. dr. S.A. Reijneveld Prof. dr. J.M. Geleijnse Prof. dr. E.J. Hoorn
CONTENTS
Chapter 1 General Introduction 9
Chapter 2 Urinary potassium excretion and risk of developing hypertension: Prevention of Renal and Vascular End-stage Disease study.
Hypertension 2014; 4: 769-776.
31
Chapter 3 Association of low urinary sodium excretion with increased risk of stroke.
Mayo Clin Proc 2018; 93(12): 1803-1809.
59
Chapter 4 Urinary potassium excretion and risk of cardiovascular events.
Am J Clin Nutr 2016; 103: 1204-12.
77
Chapter 5 Low potassium excretion but not high sodium excretion is associated with increased risk of developing chronic kidney disease.
Kidney Int 2016; 90; 888-896.
119
Chapter 6 Urinary potassium excretion, renal ammoniagenesis and risk of graft failure and mortality in renal transplant recipients.
Am J Clin Nutr 2016; 104: 1703-11.
153
Chapter 7 Plasma potassium, diuretic use and risk of developing chronic kidney disease in a predominantly white population.
PLoS ONE 2017; 12(3): e0174686.
187
Chapter 8 General Discussion and Conclusions 219
Nederlandse samenvatting/Dutch summary 243
Dankwoord/Acknowledgements 253
Author Affiliations 261
About the author 265
