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University of Groningen Perioperative renal protective strategies in kidney transplantation Nieuwenhuijs, Gertrude Johanna

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University of Groningen

Perioperative renal protective strategies in kidney transplantation

Nieuwenhuijs, Gertrude Johanna

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

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Publication date: 2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Nieuwenhuijs, G. J. (2019). Perioperative renal protective strategies in kidney transplantation. Rijksuniversiteit Groningen.

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Perioperative renal protective

strategies in kidney transplantation

Gertrude Johanna Nieuwenhuijs-Moeke

Perioperative renal protective

strategies in kidney transplantation

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Financial support for this thesis was provided by:

Graduate School of Medical Sciences Nierstichting Nederland

Nederlandse Transplantatie Vereniging Astellas Pharma BV

Chiesi Pharmaceuticals BV

Layout Bianca Pijl, www.pijlldesign.nl,

Groningen, the Netherlands

Cover Photography Marie Cécile Thijs Printed by Ipskamp Printing

Enschede, the Netherlands

ISBN 978-94-028-1371-5 (print)

© Copyright 2019 G.J. Nieuwenhuijs-Moeke, Groningen, the Netherlands

All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author, or when appropriate, of the publishers of the publications included in this thesis.

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Perioperative renal protective

strategies in kidney transplantation

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties

De openbare verdediging zal plaatsvinden op woensdag 27 maart 2019 om 16.15 uur

door

Gertrude Johanna Moeke geboren op 17 januari 1976

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Promotores Prof. dr. M.M.R.F. Struys Prof. dr. H.G.D. Leuvenink Prof. dr. R.G. Ploeg Copromotor Dr. V.B. Nieuwenhuijs Beoordelingscommissie Prof. dr. A. R. Absalom Prof. dr. B. Beck-Schimmer Prof. dr. G. Molema

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Voor Reinoud en Juliette The individual has always had to struggle to keep from being overwhelmed by the tribe.

If you try it, you will be lonely often and sometimes frightened. But no price is too high to pay

for the privilege of owning yourself Friedrich Nietzsche

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Paranimfen Frouckje Hoekstra Martine Moeke

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Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9 Chapter 10 Table of contents Introduction and rationale Mechanisms in injury and repair

Renoprotective capacities of non-erythropoietic EPO derivative, ARA290, following renal ischemia/reperfusion injury

ARA290, a non-erythropoietic EPO derivative, attenuates renal ischemia/reperfusion injury

Molecular mechanisms of renal ischemic conditioning strategies

Remote ischemic conditioning on recipients of deceased renal transplants does not improve early graft function. First results from the multicenter, randomised, controlled clinical trial CONTEXT

A propofol based anesthesia versus a sevoflurane based anesthesia in living donor kidney transplantation, results of the VAPOR-1 randomized controlled trial

Preemptively and non-preemptively transplanted patients show a comparable hypercoagulable state prior to kidney transplantation compared to living kidney donors

Intraoperative fluid restriction is associated with functional delayed graft function in living donor kidney transplantation, a clinical experience General discussion and future perspectives

Summary Nederlandse samenvatting List of publications List of abbreviations Biography Dankwoord

Addendum 1: protocol article CONTEXT Addendum 2: supplemental material VAPOR

9 23 53 69 85 125 141 167 191 207 245 251 263 269 279 283 295 307

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