University of Groningen
Immuno-oncology of gynecological malignancies
Komdeur, Fenne Lara
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date:
2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Komdeur, F. L. (2018). Immuno-oncology of gynecological malignancies: From bench to bedside.
Rijksuniversiteit Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
IMMUNO-ONCOLOGY
OF GYNECOLOGICAL
MALIGNANCIES
F R O M B E N C H TO B E D S I D E
COLOFON
Layout and cover design: Design Your Thesis, www.designyourthesis.com Printing: Ridderprint B.V., www.ridderprint.nl
ISBN: 978-94-034-1114-9 ISBN (Ebook) 978-94-034-1113-2
Copyright © 2018 by Fenne Komdeur. All rights reserved. Any unauthorized reprint or use of this material is prohibited. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without written permission of the author or, when appropriate, of the publishers of the publications.
Printing of this thesis was financially supported by the University of Groningen, University Medical Center Groningen, Graduate School of Medical Sciences and Vicinivax BV.
IMMUNO-ONCOLOGY OF GYNECOLOGICAL
MALIGNANCIES
FROM BENCH TO BEDSIDE
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 21 november 2018 om 16.15 uur
door
Fenne Lara Komdeur
geboren op 19 november 1988
te Nijmegen
Promotores
Prof. dr. H.W. Nijman Prof. dr. C.A.H.H. Daemen
Copromotor
Dr. M. de Bruyn
Beoordelingscommissie
Prof. dr. J.P. Medema Prof. dr. R.K. Weersma Prof. dr. S.A. Scherjon
Paranimfen
Dr. F.A. Eggink Dr. I.S. Bakker
TABLE OF CONTENTS
CHAPTER 1.
General introduction7
CHAPTER 2.
CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy.Oncotarget. 2016
19
CHAPTER 3.
CD103 defines intraepithelial CD8+ PD1+ tumor-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma.European Journal of Cancer. 2016
49
CHAPTER 4.
CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer.Oncoimmunology. 2017
71
CHAPTER 5.
Treatment regimen, surgical outcome, and T cell differentiation influence prognostic benefit of tumor-infiltrating lymphocytes in high-grade serous ovarian cancer.Clinical Cancer Research. 2015
103
CHAPTER 6.
Size matters: survival benefit conferred by intratumoral T cells is dependent on surgical outcome, treatment sequence and T cell differentiation.Oncoimmunology. 2015
127
CHAPTER 7.
Systemic immunological changes during first line chemotherapy in patients with high-grade serous ovarian cancer.Submitted
