Chemical and process-design intensification and use for
micro-flow particle synthesis
Citation for published version (APA):
Hessel, V., Noel, T., & Wang, Q. (2015). Chemical and process-design intensification and use for micro-flow particle synthesis. In Proceedings of the International Powder and Nanotechnology Forum (ACHEMA 2015), 16/17 June 2015, Frankfurt am Main, Germany
Document status and date: Published: 01/01/2015 Document Version:
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Chemical and Process-Design Intensification
and Use for Micro-Flow particle synthesis
V. Hessel, T. Noel, Q. Wang, Eindhoven University of Technology, Micro Flow Chemistry and Process Technology, Eindhoven, the Netherlands
Means of flow intensification Micro process technology has given strong push to
conti-nuous chemical manufacture via facilitating heat and mass transfer; named transport intensification. Next big step was to develop tailored process chemistry in flow under highly intensified conditions – which is major essence in the field of Flow Chemistry. This has been coined Novel Process Windows and has two research pillars – the exploration of unusual and typically harsh process conditions (chemical intensification) and, in more holistic picture, an entirely new (end-to-end), highly integrated or simpler process design (process-design intensification). A survey based on several own-deve-loped flow chemistries will underpin the above. This will demonstrate how to boost reactivity via high-T, high-p, high-c (solvent-free; alternative solvent) concepts.
Impact on micro-flow particle synthesis Novel process windows have also promoted
micro-flow particle synthesis. Most pronounced is this for the cascaded processing (reaction integration) of the diverse elemental steps needed to make a nanoparticle. Taking the example of gold nanoparticles, reduction, seed formation, seed growth, and particle stabilization (polymer adsorption) happen all under the same reaction condi-tions in a batch reactor. Contrarily, in a micro-flow system, these can be treated sepa-rately in time and space for the benefit of their individual optimization. High-tempera-ture flow operation is a second NPW-motif used for flow particle synthesis. This, e.g., allows to replace costly high-temperature solvents by cheaper low-boiling solvents, now operated under superheated conditions. A compilation on worldwide research in these two innovation drivers will be given which will be completed by classical and most modern researches in transport intensification for micro-flow particle synthesis. Emphasis will be on metal [1] and polymer [2] micro and nanoparticles.
[1] E. Shahbazali, V. Hessel, T. Noël, Q. Wang (2014) Metallic nanoparticles made in flow and
their catalytic applications in organic synthesis. Nanotechnology Reviews 3(1), 65-86.
[2] C. Serra, B. Cortese, I. Ullah Khan, N. Anton, N., M.H.J.M. de Croon, V. Hessel, T. Ono, Th. Vandamme (2013) Coupling microreaction technologies, polymer chemistry, and
pro-cessing to produce polymeric micro and nanoparticles with controlled size, morphology, and composition. Macromolecular Reaction Engineering 7(9), 414-439.
