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UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl)

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Vascular damage and dysfunction in hypertensive emergencies

Amraoui, F.

Publication date

2017

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Other version

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Citation for published version (APA):

Amraoui, F. (2017). Vascular damage and dysfunction in hypertensive emergencies.

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VASCULAR D

AMA

GE AND D

YSFUNC

TION IN HYPER

TENSIVE EMER

GENCIE

S

Fouad Amr

aoui

VASCULAR DAMAGE AND DYSFUNCTION

IN HYPERTENSIVE EMERGENCIES

UITNODIGING

Voor het bijwonen van de openbare verdediging van

het proefschrift

VASCULAR DAMAGE

AND DYSFUNCTION

IN HYPERTENSIVE

EMERGENCIES

Op donderdag 9 februari 2017 14:00 uur in de Agnietenkapel Oudezijds Voorburgwal 231 Amsterdam Receptie na afloop van de promotie Paranimfen: Sietse Boogmans Alex Wagemakers FOUAD AMRAOUI CLARISSENHOF 121, 1115 CD DUIVENDRECHT F.AMRAOUI@AMC.UVA.NL

Fouad Amraoui

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VASCULAR DAMAGE AND DYSFUNCTION

IN HYPERTENSIVE EMERGENCIES

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COLOFON

All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without the written permission of the author:

Author: Fouad Amraoui Cover: Mhamed Yahiaoui Layout: Gildeprint Printing: Gildeprint ISBN: 978-94-6233-530-1

Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowdledged.

Further financial support for printing this thesis was kindly provided by: the Dutch Kidney Foundation, Astellas, Pfizer, Sanofi, Chipsoft, Stichting tot Steun Promovendi Vasculaire Geneeskunde and the Academic Medical Center

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VASCULAR DAMAGE AND DYSFUNCTION

IN HYPERTENSIVE EMERGENCIES

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctor

aan de Universiteit van Amsterdam op gezag van de Rector Magnificus

prof. dr. ir. K.I.J. Maex

ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel

op donderdag 9 februari 2017, te 14:00 uur

door Fouad Amraoui geboren te Haarlem

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PROMOTIECOMMISSIE

Promotores: Prof. dr. S. Middeldorp Universiteit van Amsterdam Prof dr. J.M. van der Post Universiteit van Amsterdam

Co-promotores: Dr. B.J.H. van den Born Universiteit van Amsterdam Dr. L. Vogt Universiteit van Amsterdam Overige leden: Prof. dr. E.T. van Bavel Universiteit van Amsterdam Prof. dr. F.J. Bemelman Universiteit van Amsterdam Prof. dr. H.R. Büller Universiteit van Amsterdam Dr. A.T. Lely Universiteit Utrecht Prof. dr. M. Nieuwdorp Universiteit van Amsterdam Prof. dr. Y.M. Smulders Vrije Universiteit Amsterdam

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TABLE OF CONTENTS

Chapter 1 Introduction and outline of this thesis 9 Part I Cardiovascular and renal complications of malignant hypertension Chapter 2 Mortality and Cardiovascular Risk in Patients with a History of 25

Malignant Hypertension: a Case-Control Study

Chapter 3 Long-term renal outcome in patients with malignant hypertension: 37 a retrospective cohort study

Chapter 4 Value of retinal examination in hypertensive encephalopathy 51 Part II Role of anti-angiogenic factors in the pathophysiology of pre-eclampsia Chapter 5 SFlt-1 elevates blood pressure by augmenting endothelin-1-mediated 65

vasoconstriction in mice

Chapter 6 Potential role for aspirin in the prevention of pre-eclampsia-like 83 syndrome in bevacuzimab-treated patients with colorectal carcinoma Chapter 7 Syndecan-1 and glycosaminoglycans in pre-eclamptic and 95

normotensive pregnancies

Chapter 8 Placental expression of heparan sulfate 3-O-sulfotransferase-3A1 113 in normotensive and pre-eclamptic pregnancies

Chapter 9 Microvascular glycocalyx dimension estimated by automated SDF 129 imaging is not related to cardiovascular disease

Chapter 10 Sphingolipid metabolism in pre-eclamptic and normotensive 143 pregnancies

Chapter 11 Summary and perspectives 159

Appendices Nederlandse samenvatting 173

Authors and affiliations 179

Dankwoord 183

Portfolio 186

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