Molecular Diagnostics of Uncommon Soft Tissue and Bone Tumors

University of Groningen

Molecular Diagnostics of Uncommon Soft Tissue and Bone Tumors Song, Wangzhao

DOI:

10.33612/diss.127007579

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Publication date: 2020

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Song, W. (2020). Molecular Diagnostics of Uncommon Soft Tissue and Bone Tumors. University of Groningen. https://doi.org/10.33612/diss.127007579

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Propositions accompanying the dissertation

Molecular Diagnostics of Uncommon

Soft Tissue and Bone Tumors

Wangzhao Song

1. CellientTM _{automated cell block technique has great potential for the}

cytological diagnosis of soft tissue and bone tumors (this thesis).

2. NanoString FusionPlex assay is a rapid, cost-effective, sensitive, and specific ancillary screening tool for molecular diagnosis of five soft tissue tumor types (this thesis).

3. Myoepithelial tumors of bone illustrate the challenge pathologists face in daily diagnostic work (this thesis).

4. PHF1-TFE3 fusions occur in a subset of ossifying fibromyxoid tumors with aggressive clinical behavior (this thesis).

5. Soft tissue aneurysmal bone cysts belong to a spectrum of tumors with USP6 gene rearrangements (this thesis).

6. Molecular analysis may contribute in discriminating low-grade central fibroblastic osteosarcoma from desmoplastic fibroma (this thesis).

7. Recognizing soft tissue tumors associated with NTRK and other kinase related fusions opens new avenues for targeted therapy.

8. Dreams are worth dreaming, as even an impossible one might come true. 9. Some things force you to grow overnight; some people make you grateful all