Improving gene function predictions using independent transcriptional components

Op een perceel tussen de Nieuwstraat en de Korte Nieuwstraat (Afb. 6, 4) werd in 2001 een archeologisch onderzoek uitgevoerd waarbij bewoningssporen en afvalcontexten uit de

Linking common and rare disease genetics to identify core genes using Downstreamer. Discussion 25 39 69 89 123 171 195 Chapter 1 Introduction 11 Appendices Summary

A number of factors influence the success of a GWAS: the study sample size, the genetic architecture of the trait (i.e. the allele frequency and effect size distribution of

In this review, we compare detected effect size and allele frequencies of associated variants from genome-wide association studies (GWAS) on complex traits and diseases with

Covariates For age, correcting solely for technical covariates or cell-counts resulted in a large increase (119% compared to the base model) in replicated genes. For BMI and

MR-link uses summary statistics of an exposure combined with individual-level data on the outcome to estimate the causal effect of an exposure from IVs (i.e. eQTLs if the exposure

This indicates that we prioritise core genes mostly for traits where blood is the relevant tissue, as expected under the omnigenic model, where all genes expressed in

After comparing the effect sizes of previously reported associations between SNPs and these data layers, we conclude that genetic variation can have a large effect on nearby