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Neisseria gonorrhoeae: testing, typing and treatment in an era of increased
antimicrobial resistance
Wind, C.M.
Publication date
2017
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Citation for published version (APA):
Wind, C. M. (2017). Neisseria gonorrhoeae: testing, typing and treatment in an era of
increased antimicrobial resistance.
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Neisseria gonorrhoeae:
testing, typing and treatment
in an era of increased
antimicrobial resistance
Carolien Wind
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Neisseria gonorrhoeae:
testing, typing and treatment in an era of increased
antimicrobial resistance
Carolien Wind
Neisseria gonorrhoeae: testing, typing and treatment in an era of increased antimicrobial resistance
Thesis, University of Amsterdam, the Netherlands ISBN 978-94-6332-118-1
© Carolien Marleen Wind, 2017
All rights reserved. No part of this thesis may be reproduced in any way or by any means without the prior permission of the author. Published articles were reprinted with permission from the publisher.
Cover design by Marja Boortman
Layout by Ferdinand van Nispen tot Pannerden, Citroenvlinder DTP&Vormgeving, my-thesis.nl
Printed by GVO drukkers & vormgevers B.V.
The printing of this thesis was financially supported by the Public Health Service of Amsterdam (GGD Amsterdam); the Academic Medical Center of the University of Amsterdam; Hologic; Copan Italia; Huidstichting Chanfleury van IJsselsteijn; Condomerie; Roche Diagnostics; Abbott BV. Their financial contributions are greatly appreciated.
Neisseria gonorrhoeae:
testing, typing and treatment in an era of
increased antimicrobial resistance
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel
op vrijdag 31 maart 2017, te 10:00 uur
door
Carolien Marleen Wind geboren te Utrecht
Promotiecommissie:
Promotor:
Prof. dr. H.J.C. de Vries Universiteit van Amsterdam Copromotores:
Dr. A.P. van Dam GGD Amsterdam Dr. M.F. Schim van der Loeff GGD Amsterdam
Overige leden:
Prof. dr. R. Hoekzema Universiteit van Amsterdam Prof. dr. J.M. Prins Universiteit van Amsterdam Prof. dr. J.E.A.M. van Bergen Universiteit van Amsterdam Prof. dr. C.A. Ison Emeritus - Imperial College London
Dr. L.M. Schouls Rijksinstituut voor Volksgezondheid en Milieu Dr. K.D. Quint Leids Universitair Medisch Centrum
Faculteit der Geneeskunde
TABLE OF CONTENTS
Chapter 1 Introduction 9
Part I. The improvement of diagnostic methods and the evaluation of treatment
23 Chapter 2 Successful combination of nucleic acid amplification test
diagnostics and targeted deferred Neisseria gonorrhoeae culture
J Clin Microbiol. 2015;53(6):1884–90
25
Chapter 3 Test of cure for anogenital gonorrhoea using modern RNA-based and DNA-RNA-based nucleic acid amplification tests: a prospective cohort study
Clin Infect Dis. 2016;62(11):1348–55
45
Chapter 4 Time to clearance of Chlamydia trachomatis RNA and DNA after treatment in patients coinfected with Neisseria
gonorrhoeae – a prospective cohort study BMC Infect Dis. 2016;16:554
65
Part II. Antimicrobial resistance threatening current and future treatment options
81 Chapter 5 Trends in antimicrobial resistance for azithromycin and
ceftriaxone in Neisseria gonorrhoeae isolates, in Amsterdam between 2012 and 2015
Euro Surveill. 2016; In Press
83
Chapter 6 Determination of in vitro synergy for dual antimicrobial therapy against resistant Neisseria gonorrhoeae using Etest and agar dilution
Int J Antimicrob Agents. 2015;45:305–8
105
Chapter 7 Decreased azithromycin susceptibility of Neisseria
gonorrhoeae isolates in patients recently treated with
azithromycin
Submitted for publication
119
Chapter 8 Molecular epidemiology in relation to azithromycin resistance in Neisseria gonorrhoeae isolates from
Amsterdam, the Netherlands, between 2008 and 2015 – a case-control study
Submitted for publication
137
Chapter 9 General Discussion 159
Appendix Summary 181
Nederlandse samenvatting 187
Acknowledgements / Dankwoord 192
About the author 195
List of publications 196
List of contributing authors 198
Portfolio 199
