Petroleum-based Safe Process Oils: From Solubility Aspects to Practical Use in Carbon Black-Reinforced Rubber Compounds

Proceedings

International Polymer Conference of Thailand

Annual Polymer Conference

June 30-July 1, 2016

Pathumwan Princess Hotel, Bangkok

Thailand

PCT-6-

The Annual Place and Time with Good Memories

Suwabun Chirachanchai, Ph.D.

PCT-6 Chairman

he Polymer Society of Thailand (PST) was founded in 1999 by Thai academic and

T

industrial polymer scientists. The society plays its important role as the network for the community so

that the research, development and innovation in the country can go beyond. In order to achieve this

goal, the PST realizes the annual conference to organize the Polymer Conference of Thailand (PCT)

since 2010 as a stage to strengthen the network where the advancement of polymer can be cultivated

through the presentations, discussions, idea exchanging, and collaborations among the members either

from academia or industrial sector. The PST also considered the PCT as the stage to express the

recognition the young polymer scientists in the country and announce its 'Thai Polymer Society

Rising Star' since PCT-3. In PCT-5, the scope was extended to an international conference where the

Plenaries, Keynotes, and students are invited from abroad so that the international networks and

collaborations as well as the raising of the quality can be expected.

In fact, the uniqueness of PCT is that it is the only conference for Polymer People in the

country and this has proven by PCT-6 with an impressive number of participants (over 300) including

more than 60 oral presentations and more than 90 poster presentations. The PCT-6 receives its honor

to have 3 Plenary speakers from Universities; Prof. Atsushi Takahara (Kyushu University), Prof.

Jean-François Pilard (Université du Maine, Le Mans), and Prof. Pramuan Tangboriboonrat (Mahidol

University), and 2 Plenaries from the Industries; Dr. Teeradetch Tungsubutra (PTT Research &

Technology Institute) and Dr. Butra Boonliang (SCG Research & Development Center). The PCT-6 is

also pleased to have 10 Keynotes from abroad; Prof. Doo Sung Lee (SKKU University, Korea), Prof.

Xiao Matthew Hu (Nanyang University of Technology, Singapore), Prof. Toshikazu Takata (Tokyo

Institute of Technology, Japan), Prof. Dr.-Ing. Alois K. Schlarb (University of Kaiserslautern,

Germany), Prof. Dr. Sahrim Hj. Ahmad (Polymer Research Center (PORCE), Universiti Kebangsaan

Malaysia, Malaysia), Prof. Matthias Driess (Technische Universitaet Berlin), Prof. Paul D. Lickiss

(Imperial College, UK), Dr. Li Xu (Institute of Materials Research and Engineering (IMRE),

Singapore), Assoc. Prof. Dr. Hiroharu Ajiro (Nara Institute of Science and Technology (NAIST),

Japan), Assoc. Prof. Dr. Loo Say Chye Joachim (Nanyang Technological University, Singapore), and

7 Keynotes from Thailand; Dr. Daniel Crespy (Vidyasirimedhi Institute of Science and Technology,

Thailand), Assoc. Prof. Dr. Voravee P. Hoven (Department of Chemistry, Chulalongkorn University),

Assoc. Prof. Dr. Nisanart Traiphol (Department of Material Science, Chulalongkorn University), Asst.

Prof. Dr. Kannika Sahakaro (Department of Rubber Technology and Polymer, Prince of Songkla

University), Assoc. Prof. Dr. Thanyalak Chaisuwan, (The Petroleum and Petrochemical College,

Chulalongkorn University), and Dr. Katanchalee Mai-ngam (Biomedical Engineering Research Unit,

National Metal and Materials Technology Center (MTEC)).

The PCT-6 wishes to congratulate Assoc. Prof. Dr. Chatthai Kaewtong (Department of

Chemistry and Center of Excellence for Innovation in Chemistry, Mahasarakham University), and

Assoc. Prof. Dr. Napida Hinchiranan (Department of Chemical Technology, Chulalongkorn

University) for their excellent and distinguish achievements to be the PCT-6 Rising Stars.

On behalf of the Thai Polymer Society, I would like to express my deepest gratitude to all

speakers, participants, and the committee members and staff to make PCT-6 becomes real The

gratitude is extended to the sponsors, which are the SCG Chemicals, PTT Global Chemicals, IRPC,

Bruker BioSpin AG, and BASF (Thai) Ltd., as well as the 11 booth exhibitors.

Last but not least, I would like to deliver my appreciation to all participants who believe that

PCT is the annual place and time for Polymer People in the Country.

Board of Polymer Society of Thailand

Advisory board

Asst. Prof. Dr. Krisda Suchiva

National Metal and Materials Technology Center (MTEC)

Prof. Dr. Pattarapan Prasassarakich

Department of Chemical Technology, Chulalongkorn University

Prof. Dr. Supawan Tantayanon

Department of Chemistry, Chulalongkorn University

Prof. Dr. Suda Kiatkamjornwong

Faculty of Science, Chulalongkorn University

President

Prof. Dr. Suwabun Chirachanchai

The Petroleum and Petrochemical College, Chulalongkorn University

Vice President

Assoc. Prof. Dr. Pranee Phinyocheep

Department of Chemistry, Mahidol University

Vice President

PTT Global Chemical Public Company Limited

Secretary

Asst. Prof. Dr. Varawut Tangpasuthadol

Department of Chemistry, Chulalongkorn University

Treasurer

Department of Material Science, Chulalongkorn University

Committee

Assoc. Prof. Dr. Ittipol Jangchud

Department of Chemistry, King Mongkut’s Institute of Technology Ladkrabang

Committee

Department of Chemistry, Chiang Mai University

Committee

Assoc. Prof. Dr. Pakorn Opaprakasit

Sirindhorn International Institute of Technology, Thammasat University

Committee

National Metal and Materials Technology Center (MTEC)

Board of Polymer Society of Thailand

(continued)

Committee

Asst. Prof. Dr. Kannika Sahakaro

Faculty of Science and Technology, Prince of Songkla University, Pattani Campus

Committee

BASF (Thai) Limited

Committee

Dr. Pasaree Laokijcharoen

National Metal and Materials Technology Center (MTEC)

Committee

PTT Public Company Limited

Committee

Dr. Warayuth Sajomsang

National Nanotechnology Center (NANOTEC)

Committee

Department of Chemistry, Mahidol University

Committee

Dr. Wonchalerm Rungswang

Conference Committee

Chairman

Prof. Suwabun Chirachanchai The Petroleum and Petrochemical College, Chulalongkorn University

International Advisory Committee

Prof. Atsushi Takahara

Kyushu University, Japan

Prof. Garry L. Rempel

University of Waterloo, Canada

Prof. Jean Francois Pilard

University of Le Maine, France

Prof. Doo Sung Lee

Sung Kyun Kwan University, Korea

Prof. Xiao Matthew Hu

Nanyang Technological University, Singapore

Assoc. Prof. Loo Say Chye Joachim

Nanyang Technological University, Singapore

Prof. Toshikazu Takata

Tokyo Institute of Technology, Japan

Prof. Alois K. Schlarb

University of Kaiserslautern, Germany

Prof. Sahrim Hj. Ahmad

Universiti Kebangsaan Malaysia, Malaysia

Dr. Azizah Baharum

Universiti Kebangsaan Malaysia, Malaysia

Prof. Matthias Driess

Technische Universitaet Berlin, Germany

Prof. Paul D. Lickiss

Imperial College London, UK

Dr. Li Xu

Institute of Materials Research and Engineering,

Singapore

Assoc. Prof. Hiroharu Ajiro

Nara Institute of Science and Technology, Japan

Assoc. Prof. Kinsuk Naskar

Indian Institute of Technology Kharagpur, India

Assoc. Prof. Nadras Othman

Universiti Sains Malaysia, Malaysia

Assoc. Prof. Yoshimasa Yamamoto

Tokyo National College of Technology, Japan

Dr. Daniel Crespy

Vidyasirimedhi Institute of Science and Technology

Scientific Committee

Prof. Atsushi Takahara

Kyushu University, Japan

Prof. Garry L. Rempel

University of Waterloo, Canada

Prof. Jean Francois Pilard

University of Le Maine, France

Prof. Doo Sung Lee

Sung Kyun Kwan University, Korea

Prof. Xiao Matthew Hu

Nanyang Technological University, Singapore

Assoc. Prof. Loo Say Chye Joachim

Nanyang Technological University, Singapore

Prof. Toshikazu Takata

Tokyo Institute of Technology, Japan

Prof.-Ing. Alois K. Schlarb

University of Kaiserslautern, Germany

Prof. Sahrim Hj. Ahmad

Universiti Kebangsaan Malaysia, Malaysia

Dr. Azizah Baharum

Universiti Kebangsaan Malaysia, Malaysia

Prof. Matthias Driess

Technische Universitaet Berlin, Germany

Prof. Paul D. Lickiss

Imperial College London, UK

Dr. Li Xu

Institute of Materials Research and Engineering,

Singapore

Assoc. Prof. Hiroharu Ajiro

Nara Institute of Science and Technology, Japan

Assoc. Prof. Kinsuk Naskar

Indian Institute of Technology Kharagpur, India

Assoc. Prof. Nadras Othman

Universiti Sains Malaysia, Malaysia

Assoc. Prof. Yoshimasa Yamamoto

Tokyo National College of Technology, Japan

Prof. Pattarapan Prasassarakich

Chulalongkorn University

Prof. Suda Kiatkamjornwong

Chulalongkorn University

Prof. Supawan Tantayanon

Chulalongkorn University

Prof. Suwabun Chirachanchai

Chulalongkorn University

Assoc. Prof. Nuanphun Chantarasiri

Chulalongkorn University

Assoc. Prof. Rathanawan Magaraphan

Chulalongkorn University

Assoc. Prof. Voravee Hoven

Chulalongkorn University

Assoc. Prof. Sirilux Poompradub

Chulalongkorn University

Assoc. Prof. Napida Hinchiranan

Chulalongkorn University

Asst. Prof. Varawut Tangpasuthadol

Chulalongkorn University

Asst. Prof. Kanoktip Boonkerd

Chulalongkorn University

Prof. Pramuan Tangboriboonrat

Mahidol University

Assoc. Prof. Pranee Phinyocheep

Mahidol University

Assoc. Prof. Sombat Thanawan

Mahidol University

Assoc. Prof. Chakrit Sirisinha

Mahidol University

Assoc. Prof. Taweechai Amornsakchai

Mahidol University

Assoc. Prof. Kalyanee Sirisinha

Mahidol University

Assoc. Prof. Panya Sunintaboon

Mahidol University

Assoc. Prof. Vuthichai Ervithayasuporn

Mahidol University

Asst. Prof. Thammasit Vongsetskul

Mahidol University

Dr. Anyarat Watthanaphanit

Mahidol University

Assoc. Prof. Pakorn Opaprakasit

Thammasat University

Assoc. Prof. Cattaleeya Pattamaprom

Thammasat University

Asst. Prof. Suwadee Kongparakul

Thammasat University

Asst. Prof. Pimpa Hormnirun

Kasetsart University

Assoc. Prof. Ittipol Jangchud

King Mongkut’s Institute of Technology Ladkrabang

Assoc. Prof. Patrawuth Monwiset

King Mongkut’s Institute of Technology Ladkrabang

Assoc. Prof. Tawan Sooknoi

King Mongkut’s Institute of Technology Ladkrabang

Asst. Prof. Chonlada Ritvirulh

King Mongkut’s Institute of Technology Ladkrabang

Asst. Prof. Suparat Rukchonlatee

King Mongkut’s Institute of Technology Ladkrabang

Dr. Robert Molloy

Chiang Mai University

Asst. Prof. Winita Punyodom

Chiang Mai University

Asst. Prof. Jantrawan Pumchusak

Chiang Mai University

Asst. Prof. Kanarat Nalampang

Chiang Mai University

Dr. Kiattikhun Manokruang

Chiang Mai University

Dr. Patnarin Worajittiphon

Chiang Mai University

Dr. Runglawan Somsunan

Chiang Mai University

Assoc. Prof. Metha Rutnakornpituk

Naresuan University

Asst. Prof. Sukunya Ross

Naresuan University

Dr. Katanchalee Mai-Ngam

National Metal and Materials Technology Center

(MTEC)

Dr. Asira Fuongfuchat

National Metal and Materials Technology Center

(MTEC)

Dr. Pasaree Laokijcharoen

National Metal and Materials Technology Center

(MTEC)

Dr. Nispa Seetapan

National Metal and Materials Technology Center

(MTEC)

Dr. Siriporn Tanodekaew

National Metal and Materials Technology Center

(MTEC)

Dr. Warayuth Sajomsang

National Nanotechnology Center (NANOTEC)

Dr. Chalita Ratanatawanate

National Nanotechnology Center (NANOTEC)

Dr. Sineenat Thaiboonrod

National Nanotechnology Center (NANOTEC)

Dr. Suvimol Surassmo

National Nanotechnology Center (NANOTEC)

Dr. Teerapong Yata

National Nanotechnology Center (NANOTEC)

Asst. Prof. Polphat Ruamcharoen

Songkhla Rajabhat University

Asst. Prof. Kannika Sahakaro

Prince of Songkla University, Pattani Campus

Asst. Prof. Anoma Thitithammawong

Prince of Songkla University, Pattani Campus

Dr. Sitisaiyidah Saiwari

Prince of Songkla University, Pattani Campus

Assoc. Prof. Varaporn Tanrattanakul

Prince of Songkla University, Hat Yai Campus

Dr. Sunisa Suchat

Prince of Songkla University, Suratthani Campus

Asst. Prof. Krisda Suchiva

Rubber Technology Research Centre

Assoc. Prof. Khamphee Phomphrai

Vidyasirimedhi Institute of Science and Technology

Dr. Daniel Crespy

Vidyasirimedhi Institute of Science and Technology

Dr. Prakaipetch Kitiyanan

BASF (Thai) Limited

Dr. Teeradetch Tungsubutra

PTT Public Company Limited

Dr. Narin Kaabbuathong

PTT Public Company Limited

Dr. Veerapat Tantayakom

PTT Global Chemical Company Limited

Dr. Wonchalerm Rungswang

SCG Chemicals Company Limited

Organizing Committee

Prof. Suda Kiatkamjornwong

Faculty of Science, Chulalongkorn University

Prof. Pattarapan Prasassarakich

Department of Chemical Technology, Chulalongkorn

University

Prof. Supawan Tantayanon

Department of Chemistry, Chulalongkorn University

Asst. Prof. Krisda Suchiva

National Metal and Materials Technology Center

Assoc. Prof. Pranee Phinyocheep

Department of Chemistry, Mahidol University

Assoc. Prof. Ittipol Jangchud

Department of Chemistry, King Mongkut’s Institute

of Technology Ladkrabang

Assoc. Prof. Pakorn Opaprakasit

Sirindhorn International Institute of Technology,

Thammasat University

Assoc. Prof. Vuthichai Ervithayasuporn

Department of Chemistry, Mahidol University

Asst. Prof. Kannika Sahakaro

Faculty of Science and Technology, Prince of Songkla

University, Pattani Campus

Asst. Prof. Winita Punyodom

Department of Chemistry, Chiang Mai University

Asst. Prof. Varawut Tangpasuthadol

Department of Chemistry, Chulalongkorn University

Asst. Prof. Kanoktip Boonkerd

Department of

Material Science

, Chulalongkorn

University

Dr. Asira Fuongfuchat

National Metal and Materials Technology Center

Dr. Pasaree Laokijcharoen

National Metal and Materials Technology Center

Dr. Warayuth Sajomsang

National Nanotechnology Center

Dr. Prakaipetch Kitiyanan

BASF (Thai) Limited

Dr. Veerapat Tantayakom

PTT Global Chemical Public Company Limited

Dr. Narin Kaabbuathong

PTT Public Company Limited

Dr. Wonchalerm Rungswang

SCG Chemicals Company Limited

Regional Organizing Committee

Dr. Robert Molloy

Department of Chemistry, Chiang Mai University

Assoc. Prof. Yodthong Baimark

Department of Chemistry, Mahasarakham University

Assoc. Prof. Metha Rutnakornpituk

Department of Chemistry, Naresuan University

Assoc. Prof. Jatuphorn Wootthikanokkhan

Division of Materials Technology, King Mongkut’s

University of Technology Thonburi

Asst. Prof. Chiraphon Chaibundit

Department of Materials Science and Technology,

Prince of Songkla University, Hat-Yai Campus

Asst. Prof. Chaiwat Ruksakulpiwat

Department of Chemistry, Khon Kaen University

Asst. Prof. Suttinun Phongtamrug

Department of Industrial Chemistry, King Mongkut's

University of Technology North Bangkok

Asst. Prof. Preeyaporn Chaiyasat

Department of Chemistry, Rajamangala University of

Technology Thanyaburi

Asst. Prof. Polphat Ruamcharoen

Program of Rubber and Polymer Technology,

Songkhla Rajabhat University

Asst. Prof. Rapee Gosalawit

School of Chemistry, Suranaree University of

Technology

University

Asst. Prof. Wanvimol Pasanphan

Department of Materials Science, Kasetsart

University

Dr. Sunisa Suchart

Faculty of Science and Industrial Technology, Prince

of Songkla University, Suratthani Campus

Dr. Achara Kleawkla

Department of Chemistry, Maejo University

Dr. Boontharika Thapsukhon

School of Science, University of Phayao

Dr. Patchara Punyamoonwongsa

School of Science, Mae Fah Luang University

Dr. Nattakan Soykeabkaew

School of Science, Mae Fah Luang University

Contents

Session

Code Speaker Title / page

Plenary Lectures

1 Synchrotron Radiation Scattering and Spectroscopy Applied to Soft Matter Science 2

Atsushi Takahara

PLENARY_

2 Taking on the S-curve challenges Teeradetch Tungsubutra 3

PLENARY_

3 Open Innovation – Building Success Together Butra Boonliang 4

PLENARY_

4 From low-cost rubbers to high value materials: An alternative to standard processes 5

Jean-Francois Pilard

PLENARY_

5 Natural Rubber Latex-Based Particle Composites Pramuan Tangboriboonrat 6

Keynote lectures

BIOMAT-KN1 Functionalization of Poly(trimethylene carbonate) and Polylactide by Molecular Technology Approach 8

Hiroharu Ajiro

BIOMAT-KN2 Multifunctional Nanofibers and Nanofibrous Membranes for Environmental and Antibacterial Applications 9

Varol Intasanta

BIOMAT-KN3 pH-Triggered Targeting Polymeric Nanocarriers: Theranostic Applications Doo Sung Lee 10

BIOPOL-KN1 Particles for Biomedical Applications – Controlled Drug Delivery and Bioimaging Loo Say Chye Joachim 11

DESIGN-KN1 Unifying Catalysis Through Synthesis of Hybrid Materials Matthias Driess 12

DESIGN-KN2 Packaging Trends and Sustainable Solution Prakaipetch Kitiyanan 13

DESIGN-KN3 Gold Nanorods Stabilized by Drug-Conjugated Polymer for Synergistic Cancer Therapy 14

Voravee Hoven

ENERGY-KN1 Main-Group Elements in Coordination Polymers for Energy Applications 15

Paul D. Lickiss

ENERGY-KN2 High Performance Polymeric Materials and Their Applications 16

Xu Li

ENERGY-KN3 Structural Design of Benzoxazine-derived Nanoporous Carbon Electrodes for Energy Storage Devices 17

Thanyalak Chaisuwan

RUBCOM-KN1 Cross-linking That Endows Rubber with Toughness Using Rotaxane Cross-Linkers 18

Toshikazu Takata

RUBCOM-KN2 Petroleum-based Safe Process Oils: From Solubility Aspects to Practical Use in Carbon Black-Reinforced Rubber Compounds 19

Kannika Sahakaro

RUBCOM-KN3 Polymer Based Hybrid Composites for Energy-Efficient Applications 20

Alois K. Schlarb

RUBCOM-KN4 Magnetic Thermoplastic Natural Rubber Nanocomposite materials: Preparations and Applications 21

Session

Code Speaker Title / page

SMART-KN1 Some Aspects of Stimuli Responsive Polymers and their Applications 22

Xiao ‘Matthew’ HU

SMART-KN2 Polydiacetylene-Based Nanocomposite as Colorimetric Sensors 23

Nisanart Traiphol

SURF-KN1 Nanoarchitectonics for the Design of Functional Materials 24

Daniel Crespy

SURF-KN2 Self-Assembled Comb-Like Surfactant Polymers for Creation of Desirable Biomaterial

Interfaces 25

Katanchalee Mai-ngam

PST Rising Star Award Lecture

RISESTAR-1 Modeling and Simulation in Polymer Reaction Engineering: A Personal

Perspective 27

Siripon Anantawaraskul

RISESTAR-2 Rhodamine-based polymeric sensors for heavy metal ions 28

Chatthai Kaewtong

RISESTAR-3 Chemical modification via graft copolymerization of diene-based elastomers:

Synthesis and applications 29

Napida Hinchiranan

Session: Biomaterials and Biomedical Polymers

BIOMAT_O2 31 BIOMAT_O6 37 BIOMAT_O7 43 BIOMAT_O9 49 BIOMAT_O14 56 BIOMAT_P1 62 BIOMAT_P6 68 BIOMAT_P12 80 BIOMAT_P14 90 BIOMAT_P15 94 BIOMAT_P16 100

Session: Renewable Resources and Biopolymers

BIOPOL_O3 105 BIOPOL_P1 111 BIOPOL_P3 117 BIOPOL_P5 122 BIOPOL_P6 126 BIOPOL_P10 130 BIOPOL-P11 135 BIOPOL-P12 139 BIOPOL-P14 144

Session: Molecular Design, Structure and Properties of Polymers

DESIGN-O2 151 DESIGN-O3 156 DESIGN-O4 162 DESIGN-O5 167 DESIGN-P2 172 DESIGN-P3 177 DESIGN-P6 181

Session: Polymers for Optics, Electronics and Energy

Session

Code Speaker Title / page

Session: Rubber and Polymer Composites

RUBCOM-O2 194 RUBCOM-O5 197 RUBCOM-O6 202 RUBCOM-O7 208 RUBCOM-O8 213 RUBCOM-O10 220 RUBCOM-O11 225 RUBCOM-O13 230 RUBCOM-O14 237 RUBCOM-O16 243 RUBCOM-O17 249 RUBCOM-O18 255 RUBCOM-P3 261 RUBCOM-P4 267 RUBCOM-P5 273 RUBCOM-P6 279 RUBCOM-P7 284 RUBCOM-P8 290 RUBCOM-P10 296 RUBCOM-P11 302 RUBCOM-P12 307 RUBCOM-P13 312 RUBCOM-P14 317 RUBCOM-P15 322 RUBCOM-P16 328 RUBCOM-P17 333 RUBCOM-P18 340 RUBCOM-P19 346 RUBCOM-P20 353 RUBCOM-P21 359 RUBCOM-P22 365 RUBCOM-P23 369 RUBCOM-P24 374 RUBCOM-P25 380 RUBCOM-P26 385 RUBCOM-P27 389

Session: Smart and Functional Polymers

SMART_O2 395 SMART_O4 401 SMART_P4 407 SMART_P6 413 SMART_P7 419 SMART_P8 425 SMART_P9 430 SMART_P10 435

Session: Surface and Interface in Macromolecular Systems

SURF_O2 440

SURF-P8 446

SURF-P12 452

PLENARY_1

Synchrotron Radiation Scattering and Spectroscopy Applied to Soft Matter Science

Atsushi Takahara

1_{Japan Science and Technology Agency (JST), ERATO, Takahara Soft Interfaces Project} 2_{Institute for Materials Chemistry and Engineering}

3_{International Institute for Carbon-Neutral Energy Research (WPI-I2CNER), Kyushu University, 744 Motooka,}

Nishi-ku, Fukuoka 819-0395, Japan E-mail: takahara@cstf.kyushu-u.ac.jp

2003- Professor (Inst. Mater. Chem. Eng., Kyushu University) 2005-2008, 2011- Member, Science Council of Japan

2007- Editorial Board, Progress in Polymer Science 2016- Senior Editor, Langmuir

Editorial Advisory Board, Polymer Research Interests:

Structure & Properties of Polymers, Polymer Composites, Polymer Surface & Interfaces

Abstract

Synchrotron radiation produces light that is highly brilliant than conventional X-ray sources. Wave length covers from IR, soft X-ray to hard X-ray. By utilizing wide wave range and high quality of light source, various scattering and spectroscopy can be applied to various soft matter. In this presentation, the authors present our recent researches on SR-IR, XPCS, and SR-SAXS applied to soft matter characterization.

SR source generates brilliant IR beam so that we can achieve high spatial resolution mapping of surface with high SN ratio. The authors characterized the wetting of superhydrophilic polyelectrolyte brushes with water utilizing SR-IR. Reflection interference contrast microscopy showed that the contact angle of a water droplet on the surface was extremely low but remained finite, despite the high affinity of the polyelectrolytes for water. The SR-IR demonstrated that water was present even outside the droplet. These water molecules were confined to the thin brush layer and formed a highly ordered hydrogen bond network, that is, structural water.

Spontaneous molecular aggregation structure development around a crack tip of a segmented polyurethane (SPU) elastomer film consisting of hard segment (HS) and soft segment (SS) was investigated. In-situ micro-beam WAXD measurements were applied to the micrometer-scale local structure mapping at the crack tip. The local strain-induced crystallization of soft segment at a crack tip and the anisotropic HS domains alignment toward the crack tip were demonstrated. The mechanisms behind the crack arrest and mechanical strength of the polyurethane elastomer film are attributed to the local strain-induced soft segment crystallization at the crack tip, the mechanical stability of the HS domains, and local stress transfer through the HS rotation.

A molded film of single-component polymer-grafted nanoparticles (SPNP), consisting of a spherical silica core and densely-grafted polymer chains bearing hydrogen-bonding side-groups capable of physically crosslinking, was investigated by in-situ ultra-small-angle X-ray scattering (USAXS) measurement during uniaxial stretching process. USAXS revealed that the molded SPNP formed a highly oriented twinned face-center-cubic lattice structure and a [111] plane was aligned nearly parallel to the film surface at initial state. Structural analysis by in-situ USAXS using a model of uniaxial deformation induced by rearrangements of the nanoparticles revealed that the fcc lattice was distorted in the stretching direction being proportional to the macroscopic strain until the strain reached 35% and subsequently changed into the other fcc lattice with different orientations. The lattice distortion and structural transition behavior corresponded well to the elastic and plastic deformation regimes, respectively, observed in the stress-strain curve. The rearrangement mechanism of the nanoparticles is well accounted for by a strong repulsive interaction between the densely-grafted-polymer shells on the neighboring particles.

XPCS is a technique, which allow us to characterize the dynamics of nanomaterials with coherent X-ray source. The dynamical behavior of polystyrene-grafted silica nanoparticles dispersed in a polystyrene matrix was studied using XPCS. While at low temperatures the particle motion was hyperdiffusive, the motion became subdiffusive with increasing temperature. This crossover may be a result of the competition between the dynamical heterogeneity of polymer matrix around the glass transition temperature, and the interaction between the polymer brushes and the polymer matrix.

PLENARY_2

Taking on the S-curve challenges

Teeradetch Tungsubutra

PTT Research and Technical Institute, PTT Public Company Limited, Ayutthaya, Thailand

Ph.D. (Chemical Engineering) Rice University, USA

Present Executive Vice President- managing PTT Research and Technical Institute (PTT RTI), covering disciplines such as fuels, lubricants, petrochemicals, petroleum transportation, and environmental sciences

Project director for the PTT Group in the establishment of the Kamnoetvidya Science Academy (KVIS) and the Vidyasirimedhi Institute (VISTEC) –in Rayong Province.

Abstract

Currently, in a strategic meeting at any organization - in any sector- it is almost a crime if we do not mention

the word “S-curve”, or “new S-curves”. This word is almost a National Agenda at the moment due to many

factors or terms such as AEC, disruptive technologies, sustainable development, and new business platforms.

Innovations are believed to be the key driver behind the development or establishment of an S-Curve. As a

result,” researchers” and “startups” are usually considered an integral part of it (an S-Curve) as well – what

really are the connections between these terms, i.e.; innovations/ startups/ researchers?

The speakers will share his views from his organization (PTT Research and Technology Institute) addressing

the challenges and key success factors in achieving the coveted mission. At the same time, he also would like

to hear opinions from the audience on the subject matter.

PLENARY_3

Open Innovation – Building Success Together

Butra Boonliang

SCG Chemicals Co., Ltd., Bangkok, 10800, Thailand E-mail: butrab@scg.co.th

Ph.D. (Microengineering and Nanotechnology( University of Birmingham, UK 2011-Present Technology Intelligence Manager, SCG Chemicals

2010-2011 Product Development Manager, Thai Polyethylene Co.,Ltd. 2007-2010 Researcher, Thai Polyethylene Co.,Ltd.

Abstract

Open Innovation became key strategic R&D direction for major corporations in recent years. The key

concept is to utilize external ideas as well as internal ideas, and internal and external market pathways to

accelerate ideas towards commercialization. There are several models of collaborative environment as a result

of this shift in industrial approach to R&D. This talk will illustrate the potential values of each type, the

limitations, the outcomes and the corporation needed from each involved parties.

SCG Chemicals Co., Ltd. is a subsidiary of Siam Cement Group (SCG) and is one of SCG’s 3 core

businesses consisting of Chemicals, Packaging and Cement-Building Materials. SCG embarked upon the

chemicals business in 1989. At present, SCG Chemicals manufactures and supplies a full range of

petrochemical products ranging from upstream, intermediate, to downstream petrochemicals. SCG Chemicals

is now one of the largest integrated petrochemical companies in Thailand and a key industry leader in the

Asia-Pacific region.

Keywords: Open Innovation, Research and Development, SCG

PLENARY_4

From low-cost rubbers to high value materials: An alternative to standard processes

Jean-Francois Pilard

Institut des Molécules et Matériaux du Mans, UMR CNRS n°6283, Université du Maine, Avenue Olivier Messiaen, 72000 Le MANS France

E-mail: jfpilard@univ-lemans.fr

Present Professor 1st _{class at the University of Le Maine}

106 publications, 7 patents

Head of the « Chemistry and Electrochemistry of polydienes from synthetic or natural source » team (Institut des Molecules et Matériaux du Mans – UMR CNRS). Member of 5 international networks on rubber modification over the last 5 years. Involved in many industrial research programs over the 3 last years

Member of scientific committee of French Elastomer research netwok (Pôle de compétitivité Elastopôle)

Member of French Research network on Biomaterials

Abstract

Over the past decades, the scientific community paid much attention to the influence of chemical

processes on the environment. Thus, new methodologies were develop to reduce chemical pollution and the

evaluation of the impact of low concentration of chemicals on human life is still of great importance nowadays.

Even if organic chemistry was the first domain investigated, polymers were also source of questions. Are their

degradation safe ? Are they obtained with low environmental impact ? And what can we do with end-life

polymers ? Are we able to modify our processes or the polymers structure but without any change of

properties ? In the same time, the growing world population needs more and more energy, facilities,

transportation which seems highly challenging on an environmental point of view. In this respect Rubber

chemistry domain has not escape to this rule.

Indeed the consumption of synthetic or natural rubber has dramatically increase during the past 20

years since rubber has found application in almost all life domains (transportation, goods, energy, life science,

etc…). The rubber industry has well understood the neccessity to modify their processes and our scientific

community is still exploring different alternative to prevent or limitate the environmental impact of chemical

industry. Among all axis investigated, scientifics were particularly involved in thermal, mechanical or chemical

treatments leading either to new processes development or new chemical structures synthesis. The purpose of

the presentation is to tentatively suggest an alternative procedure which could be able to target high value

materials from low cost rubbers, which could be respectfull to the environment.

PLENARY_5

Natural Rubber Latex-Based Particle Composites

Pramuan Tangboriboonrat*, Jitrada Wongpreecha and Waraporn Wichaita

Bangkok 10400, Thailand

Phone +66 2201 5135, Fax +66 2354 7151, *E-Mail: pramuan.tan@mahidol.ac.th Present Department of Chemistry, Faculty of Science, Mahidol University 2015-present: Director, The Royal Golden Jubilee (RGJ) Ph.D. Program, The Thailand

Research Fund (TRF)

2015-present: Editorial Advisory Board, Maejo Engineering and Agro Industry Journal, Maejo University.

2014-present: Editorial Board, Journal of Science and Technology, Rajamangala University of Technology Thanyaburi

2010-present: Member of the Committee of Nomination (Awards), Thailand Toray Science Foundation

2009-present: Editorial Board, Trends Research in Science and Technology, Journal of Huachiew Chalermprakiet University

Present: Member of Academic Review Committee, North Bangkok University, Rajamangala University of Technology Phra Nakhon, Sirindhorn International Institute of Technology, Thammasat University

Abstract

Research and development on natural rubber (NR) latex, which would lead to its use in biomedical

and/or industrial fields, will be presented. Start from the knowledge on the structure, composition and

morphology of NR latex particles, core-shell of NR-polychloroprene (CR) latex particles were fabricated via

the heterocoagulation technique for improving the oil resistant property of NR latex film. A non-ionic

surfactant whose molecules bear poly(ethylene oxide) was adsorbed on CR particles and allowed to form

complex with indigenous surfactant (protein-lipid) on the NR particle surface. Replacing the CR with skim

latex, the naturally abundant and low cost product, was also examined. The prevulcanized or cross-linked skim

was used as agglomerating latex in the encapsulation of disinfectant agent for the preparation of NR medical

gloves. The sulphur prevulcanized (SP) NR gloves possessing antimicrobial activity were then examined by

depositing poly(methyl methacrylate) latex or silver nanoparticles stabilized by chitosan or

N,N,N-trimethylated chitosan. Recently, hollow latex (HL) particles using NR as seeds have been synthesized in

one-pot. Without core removal and solvent evaporation steps, the non-collapsed HL particles with double shell of

polymer layers and a large void cavity were generated during polymerization of divinyl benzene/methyl

methacrylate/acrylic acid monomers on the seed surface. The hollow structure could simply be tuned by

selecting an appropriate initiation system and adjusting the monomers/seed (M/S) ratio. The HL-NR particles

were successfully fabricated using tert-butyl hydroperoxide/tetraethylene pentamine redox initiation system

with limited M/S weight ratio of 4/1. This process was further adapted for the synthesis of non-spherical HL

particles, which would be potentially employed as a new type of photonic material.

Keywords: natural rubber latex particle; composite nanoparticle; hollow latex particle; heterocoagulation

BIOMAT-KN1

Functionalization of Poly(trimethylene carbonate) and Polylactide by

Molecular Technology Approach

Hiroharu Ajiro

1_{Institute for Research Initiatives, Nara Institute of Science and Technology, Takayama-cho}

8916-5, Ikoma, Nara 630-0192, Japan

2_{Graduate School of Materials Science, Nara Institute of Science and Technology,}

Takayama-cho 8916-5, Ikoma, Nara 630-0192, Japan

3_{JST PRESTO}

Phone +81-743-72-5508, Fax +81-743-72-5509, *_{E-Mail: ajiro@ms.naist.jp} Abstract

Biodegradable polymers, such as polylactide and poly(trimethylene carbonate) (PTMC), has been employed to biomedical application. In order to add the functionalities of the biodegradable polymers, the monomer and polymer structures were designed. In this study, molecular design of monomer structures, block copolymer structures, and chain end modification approaches were employed.

At first, the monomer structure was designed in order to introduce functionality. Molecular design of monomer structure is one of approaches to functionalize biodegradable polymers. PTMC is widely employed as biomaterials. Recently, the low-toxic catalyst for trimethylene carbonate (TMC) polymerization has been reported, and numerous studies have reported for PTMC modification by copolymerization, polymer reaction, and novel monomer design. In our laboratory, we designed novel monomers introducing hydrophilic moieties at side group of TMC. It is known that the novel monomer design introducing functional groups via ester and amide linkages. However, we introduced oligo ethylene glycol (OEG) units directly into TMC side group, in order to avoid the possible generation of organic acid compounds after hydrolysis. The homopolymer of PTMC derivatives, bearing OEG units at side chain, shows thermosensitive properties. The lower critical solution temperature (LCST) was varied from 30 °C to 72 °C. When the 3 units of OEG and methyl groups at side chain of TMC was polymerized, the aqueous solution of the homopolymer showed its cloud point at about 33 °C. On the other hand, when the 4 units of OEG and ethyl groups at side chain of TMC was polymerized, the aqueous solution of the homopolymer showed its cloud point at about 72 °C. These results showed the hydrophilic-hydrophobic balance influenced on the cloud point.

Secondly, the block copolymer was synthesized for the functionalization of biodegradable polymers. Block copolymer is also a popular approach to add functionalities to polymers. The hydrophilic modification of PTMC with OEG units were applied to the preparation of hydrophilic and hydrophobic block copolymer. We added methoxyethoxyl group into the TMC as monomer, and the homopolymer of the TMC derivative was used as initiator for ring opening polymerization of lactide. Then the block copolymer of PTMC derivative and PLA was obtained. The copolymer ratios of PTMC and PLA moiety were determined by 1_{H NMR as about 2:8. Using the solution of the block copolymer in}

chloroform, the spin-coated films were prepared on the glass plate. The water droplet was placed to measure contact angle in order to evaluate hydrophilicity. Interestingly, the contact of water droplet caused the contact angles to change from 80 degree to 26 degree, indicating the hydrophilicity increased. The further investigation of the surface were achieved by AFM observation. The surface roughness increased with the estimated value from 3.4 nm to 7.5 nm. This result indicate that the polymer conformation and dynamic change were generated. The elemental analysis of the thin films were achieved by XRD. Compared with the initial thin film, the intensity of carbonate region of the film after increased after water immersion. Similarly, the intensity of ether region increased, suggesting that the TMC moiety with OEG groups were moved onto the surface by the hydrophilic circumstances. On the other hand, the intensity of carbonate region and ester region decreased after the films were immersed into hexane. To add to this, the intensity of ester region increased in the circumstance. The result also implied that the PLA moiety moved onto the surface, and TMC moiety with OEG groups were moved into the film, due to the hydrophobic interaction. Therefore, the thin film of the block copolymer of soft PTMC derivative with OEG and polylactide resulted in a dynamic surface, changing contact angles of a water droplet on the surface. The decomposition behavior of the film were next investigated. The thin films of the block copolymer were prepared onto the quartz crystal microbalance (QCM) substrates. Then, they were immersed into the aqueous solution of proteinase K, which accelerate of the hydrolysis of PLLA moiety. Compared to the film of the amorphous PLLA, the crystalline PLLA showed slower degradation behavior. However, the decomposition of the block copolymer showed much slower behavior than both of amorphous PLLA and crystalline PLLA films. This experiments will contribute to the long-term release of drugs by the degradation of the polymers.

Finally, the chain end modification approach was applied. Chain end modification is also good approach to improve polymer properties. Various functional groups was introduced into initiator for lactide polymerization. After lactide polymerization, the functionality of chain end part was utilized, such as antibacterial properties. We selected catechin as anti-bacterial moiety. Catechin possesses four aromatic hydroxyl groups and one alkyl hydroxyl group, so the aromatic hydroxyl groups were protected for lactide polymerization. The antibacterial properties of the obtained polymer was evaluated. Such multi functionalization of the polymers are expected to produce the novel functional biomedical materials.

Keywords: Trimethylene carbonate, lactide, monomer design, block copolymer, chain end modification

BIOMAT-KN2

Multifunctional Nanofibers and Nanofibrous Membranes for

Environmental and Antibacterial Applications

Nakarin Subjalearndee and Varol Intasanta

Nano Functional Textile Laboratory, National Nanotechnology Center, National Science and Technology Development Agency, 111 Phahonyothin Road, Klong Nueng, Klong

Luang, Pathumthani, 12120, Thailand

Phone: +66-2564-7100 ext. 6580, E-mail: varol@nanotec.or.th

Abstract

Nanofibrous structures offer versatile platforms for functionalities and high surface area. In this presentation

work, we demonstrate syntheses, characterizations and applications of multicomponent nanofibers and

nanofibrous membranes for environmental and antibacterial applications. We first propose a conceptual design

that involves three aspects of functional incorporation—in bulk, by compositions and on surface. This simple

concept allows ones to examine endless possibilities for synthesizing multifunctional and multicomponent

nanofibers from inorganic constituents such as metals and metal oxides. As examples, we show that

photocatalytic TiO

, ZnO and WO

nanofibers can be simply fabricated via electrospinning and decorated with

noble metals and paramagnetic nanoparticles. These hybrid nanofibers embodies great potential for air- and

waterborne chemical mitigation under visible, UV or sunlight activation. However, the inherent brittleness of

these metal oxide-based nanofibers poses challenges upon their future utilizations as membranes for any

devices. As a consequent, we later innovates a new type of organic-inorganic hybrid nanofibrous membranes

with multiple functions including potent antibacterial property. It is shown that the ultrathin, lightweight and

permeable nanofibrous membranes could eliminate not only E. Coli but also tuberculosis bacteria. These

mechanically robust and flexible nanomembranes could be fabricated into nanofilters for air treatment. Finally,

these inventive multifunctional nanomembranes are expected to make extraordinary impact in solving global

environmental and health problems.

Keywords: Nanofiber, Membrane, Nanospider, Noble Metal, Antibacterial

BIOMAT-KN3

pH-Triggered Targeting Polymeric Nanocarriers: Theranostic

Applications

Doo Sung Lee

Theranostic Macromolecules Research Center (ERC), School of Chemical Engineering, Sungkyunkwan University, Korea

Phone +82-31-290-7282, Fax +82-31-292-8790, E-Mail: dslee@skku.edu

Abstract

In pharmaceutical field, small molecules drugs face a lot of challenges such as non-specific absorption, poor pharmacokinetics, and off-target accumulation; whereas the bio-macromolecular medicines are obstructed due to quick degradation, invasive nature, and non-targeting uptakes. To overcome those obstacles, drug delivery system (DDS) has gained huge interests as an emerging technique for reducing systemic drug toxicity and increasing the therapeutic efficacy. In recent years, numerous of smart artificial drug delivery systems (DDS), which can triggered-release the payload under changes in environmental factors (e.g. pH, temperature, enzyme, etc.) to achieve the ultimate goals of drug delivery system, have been evolved and developed [1]. Among those DDSs, based on the pH difference between pathological tissues and normal tissues, pH-responsive polymeric DDS can be administered directly to the blood and deliver the majority of the drug to the intended pH-gradients. Various polymeric materials have been employed to prepare nanosized pH-sensitive DDS with high potency for clinical applications [2, 3].

For last decade, our researches focus on developing the pH-triggered targeting polymeric nanocarriers, which are based on titratable-polymers/copolymers for theranostic applications. Aiming to the acidic pathological tissues like extracellular tumor tissues and ischemic stroke area, our nanocarriers can deliver and release the theranostic agents to the targeted acidic zones after a stable journey in blood circulation. Generally, our pH-sensitive amphiphilic polymers/copolymers can be prepared from hydrophilic polyethylene glycol (PEG) and pH-sensitive hydrophobic blocks as sulfonamide-related polymer, poly(β-amino ester) (PAE), and polypeptide. Firstly, Sulfonamide monomers, which have pKa 6.1-7.4 are selected to offer the titratable properties for anionic copolymers that display rapid association-dissociation transition at pH above 7.4. At pH higher than 7.4, soluble state of sulfonamide-related polymers allows to entrap pharmaceutic molecules due to the formation of micellar particles when pH drops to lower than 7.4. Secondly, PAE a well-known biodegradable cationic polymer, is mainly synthesized via Michael addition polymerization between bis(secondary amines) or primary amine monomers and bis(acrylate ester) monomers. The ionizable tertiary amine groups enable the resultant PAE undergoes a hydrophobic-hydrophilic phase transition upon pH change from basic to acidic along with the particle assembly-disassembly progression. Lastly, by using ring-opening polymerization of N-carboxyanhydride monomers to achieve polypeptide with highly feasible modification in which tertiary amine groups or other functional groups can be chemically incorporated to the peptide backbone via aminolysis process. These pH-sensitive polypeptide polymers perform dissolution and self-assembly state in acidic environment and physiological condition, respectively. Using those amphiphilic copolymers, assorted polymeric micelles and polymersomes have been erected for delivering therapeutic molecules and imaging agents, which possess high stability with long-term blood circulation, quick structure collapse inducing rapid payload release at targeted pH zones. Various hydrophobic anticancer drugs (e.g. DOX, PTX, TAXOL, CPT, etc.) and therapeutic macromolecules (e.g. DNA, SDF-1α, etc.) have been physically encapsulated to evaluate applicability of our DDS through a series of in vitro and in vivo experiments. Alternatively, inorganic imaging agents such as iron oxides Fe3O4 nanoparticles, quantum dots (QDs) which are usually

highly toxicity due to the hazardous surfactants, can be loaded and delivered by our pH-sensitive nanocarriers. PAE or polypeptide, which contain hydrophilic shell PEG and specific functional groups can anchor on the nanoparticle’s surfaces to achieve high particle loading efficiency, protect the particle from non-specific adsorption, and diminish the systemic cytotoxicity. Thereafter, at targeting tumoral extracellular or ischemia stroke environments, Fe3O4 or QDs can be

gradually accumulated, which are able visualized by magnetic resonance imaging (MRI) and in vivo imaging system (IVIS). Those positive results of therapeutic efficiency as well as high intensive diagnostic demonstrated the clinical potential of our propose concepts. Further details about our achievements shall be discussed in our delivered presentation.

Keywords: pH, targeting, nanocarriers, cancer theranostic.

BIOPOL-KN1

Particles for Biomedical Applications – Controlled Drug Delivery

and Bioimaging

Loo Say Chye Joachim

School of Materials Science and Engineering (MSE), Nanyang Technological University (NTU), Singapore

joachimloo@ntu.edu.sg

Abstract

Nanotechnology has found its presence in many industries and applications, and one such promising

application is in the biomedical arena. It has been exploited for the development of nanotheranostics, for drug

delivery and bioimaging purposes. For example, drug delivery in the form of nanomedicine utilizes nano-sized

particles to transport and release pharmaceutical compound into the body, to achieve the most desirable

therapeutic outcome and in the safest possible manner. In this presentation, we will focus on how

nanotechnology can be applied for nanotheranostics, i.e. drug delivery and bioimaging. The scope will be on

the use of bottom-up approaches to develop various types of particles, and how these can be modified for

targeted, controlled and sustained release of drugs in orthopedic, geriatric, and oncologic applications. We will

also review how multi-layered and hollow particles are currently developed to deliver multiple drugs and

bioimaging probes. At the same time, this presentation would also review the toxicological responses of some

nanomaterial candidates, and how this would translate to developing safer nano-materials for biomedical

applications.

DESIGN-KN1

Unifying Catalysis Through Synthesis of Hybrid Materials

Matthias Driess

Technical University Berlin, Department of Chemistry: Metalorganics and Inorganic Materials, Strasse des 17. Juni 135, Sekr. C2, 10623 Berlin

E-mail: matthias.driess@tu-berlin.de

Abstract

Current research activities in materials chemistry are devoted to the development of innovative and abundant

materials suitable for conversion and storage of solar energy into chemicals (artificial photosynthesis). At the

same time, there is an enormous demand for innovative new materials for energy-saving in electronic devices.

Transparent conducting oxides (TCOs) are key components in organic light emitting diodes (OLED’s) for solar

cells, photocatalysts, transparent electrodes in displays and Field Effect Transistors (FET). Unfortunately,

transparent electrodes in flat-panel technology, photovoltaics or FETs rely on expensive indium tin oxide (ITO;

In

O

:Sn doped with 5% Sn) which generate a bottleneck for the growing demand, combined with the relatively

low abundance of indium. Changing the chemistry and using alternative materials systems based on abundant

metal oxides provides a solution: Applying the concept of molecular metalorganic single-source precursors

opened new doorways to innovative new TCO materials for biofuel cells and clean hydrocarbon catalysis (Fig.

1). [1-7] In my talk the key role of materials design and synthesis for defragmenting catalysis will be discussed.

Figure 1. From a molecular precursor to a bioelectrocatalytic device based on tin-rich ITO.

[1] Y. Aksu, M. Driess, Angew. Chem. Int. Ed. 2009, 48, 7778.

[2] Y. Aksu, T. Lüthge, R. Fügemann, M. Inhester, M. Driess, „Transparent electrical conducting layers: Procedure to prepare the layers and their applications”, Patent Appl. 2006E00310DE (Germany) and 102007013181.1 (China, USA) [3] Y. Aksu, S. Jana, M. Driess, Dalton Trans. 2009, 1516.

[4] M. Tsaroucha, Y. Aksu, E. Irran, M. Driess, Chem. Mater. 2011, 23, 2428–2438.

[5] Y. Aksu, S. Frasca, U. Wollenberger, M. Driess, A. Thomas, Chem. Mater. 2011, 23, 1798–1804. [6] K. Samedov, Y. Aksu, M. Driess, Chem. Eur. J. 2012, 25, 7766.

[7] A. Guiet, C. Göbel, K. Klingan, M. Lublow, T. Reier, U. Vainio, R. Kraehnert, H. Schlaad, P. Strasser, I. Zaharieva, H. Dau, M. Driess, J. Polte, A. Fischer, Adv Funct Mater 2015, 25, 6228

Acknowledgment: We thank the Cluster of Excellence “UniCat”, financed by the DFG and administered by the TU Berlin, and the BMBF (L2H) for financial support.

DESIGN-KN2

Packaging Trends and Sustainable Solution

Prakaipetch Kitiyanan

BASF (Thai) Ltd, 23rd Fl., Emporium Tower, Sukhumvit 24, Klongton, Klongtoey Thailand

Abstract

It is forecasted that the global population is growing to reach 9 billion by 2050 while there is limited resource on

earth. More and more people need access to affordable energy, housing, healthcare and quality food. There is

almost 30% food waste before entering to the supply chain. BASF looks ahead how we as a company contribute

to a sustainable future. BASF continue to develop and innovate to meet new challenges. In order to protect our

planet and to cope with the resources it provides us, the way people live has to become much more sustainable.

Packaging is one area on focus in order to reduce food waste and improve food quality as it moves through supply

chain to consumers. Packaging trend and key drivers will be discussed, including different sustainable solution

in packaging segment from BASF.

DESIGN-KN3

Gold Nanorods Stabilized by Drug-Conjugated Polymer for

Synergistic Cancer Therapy

Phim-on Khunsuk

, Supattra Chawalitpong

, Pritsana

Sawutdeechaikul

, Tanapat Palaga

and Voravee Hoven

1_{Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science,}

Chulalongkorn University, Bangkok 10330

2_{Program in Biotechnology, Faculty of Science, Chulalongkorn University,}

Bangkok 10330

3_{Department of Microbiology, Faculty of Science, Chulalongkorn University,}

Bangkok 10330

Phone +66 2218 7627, *_{E-Mail: vipavee.p@chula.ac.th}

Abstract

Taking advantages of gold nanorod (AuNRs) being capable of providing synergistic efficiency for cancer

treatment via the combination of photothermal therapy and chemotherapy and their tunable properties as a

function of stabilizer, this work aims to develop anticancer drug delivery system based on AuNRs stabilized with

poly[(methacrylic acid)-ran-(methacryloyloxyethyl phosphorylcholine)] (PMAMPC). PMAMPC was

synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. Some carboxyl groups

in PMAMPC were modified with cysteamine to introduce more thiol groups to increase active binding sites for

each PMAMPC chains onto AuNRs surface. Remaining carboxyl groups were covalently bonded with hydrazine

using EDC/NHS activation. Then, doxorubicin (DOX), an anticancer drug was conjugated to PMAMPC by

acid-labile hydrazone linkage which should be rapidly destroyed under acidic environment in lysosomes.

PMAMPC-DOX was coated on AuNRs surface via Au-S bonds. The resulting PMAMPC-PMAMPC-DOX-AuNRs showed good

colloidal stability and uniform size. Photothermal studies verified that the particles can convert the absorbed light

into heat (> 70C) when irradiated with NIR laser at 808 nm. In vitro drug release studies demonstrated that

DOX release can be significantly accelerated at pH 5.0. Effective intracellular DOX release from the

PMAMPC-DOX-AuNRs was verified by confocal laser microscopy. In vivo synergistic effect via hyperthermia and

chemotherapy apparently outperform either treatment alone. These results suggested that

PMAMPC-DOX-AuNRs could potentially be applied in pH-triggered drug delivery for cancer therapy.

Keywords: Anti-cancer drug, AuNRs, photothermal therapy, polymer stabilizer

ENERGY-KN1

Main-Group Elements in Coordination Polymers for Energy

Applications

Paul D. Lickiss* and Rob P. Davies

Department of Chemistry, Imperial College, London SW7 2AZ, UK Phone +44 (207) 594 5761, *E-Mail: p.lickiss@imperial.ac.uk

Abstract

Metal-organic frameworks (MOFs) are porous polymers in which metal centres are linked via polydentate organic linkers. They have become widely studied in recent years due to their potential in many areas such as energy, CO2

capture, catalysis, and drug delivery. These applications rely on the ability of the size, shape and chemical nature of the pores in MOFs to be tailored by suitable choice of both the metal and the organic linker. The use of main group metals as either the nodes in the polymer or as components of the linkers has been explored far less than transition metals as the nodes with well known organic linkers. The aim of this work was to demonstrate that group 1 and 2 elements may be used as nodes to prepare interesting MOFs and that organosilicon linkers can be used to give novel coordination polymers.

In group 2, Mg2+ nodes can be used to replace Zn2+ in MOFs derived from aromatic linkers such as linear 1,4- benzenedicarboxylic acid (H2bdc), 4,4-biphenyldicarboxylic acid (H2bpdc) and trigonal planar 1,3,5-tricarboxylic acid

(H3btc) [1] and Sr2+ forms a polymeric chain with [(p-CO2HC6H4)Me2Si]2O. In group 1, Li+ and Na+ both form

complicated polymers with organosilicon linkers such as (p-CO2HC6H4)3SiMe.

A wide range of useful polydentate organosilicon linkers for application in coordination polymer synthesis have been prepared using a convenient synthetic route involving simple chloro- or alkoxy-silane precursors i.e.:

This synthetic method enables simple compounds such as RnSi(p-C6H4CO2H)4-n (n = 0, 1, or 2; R = Me, Et, Ph etc.) as well as more complicated linkers such as C6H4-p-[(SiC6H4CO2H)3]2 to be prepared [2, 3]. Related silicon-based

tetrazolate linkers can be prepared from nitrile precursors prepared using a similar route to the carboxylic acids [4]. These novel linkers can be used to prepare a wide range of MOFs that have been studied for both CO2 capture and for

hydrogen storage. For example, reaction between Si(p-C6H4CO2H)4 and Co(NO3)2 affords a porous MOF, see below,

capable of hydrogen uptake [5]. This MOF, together with other MOFs containing Si linkers, will be described.

A view down the x-axis of the MOF formed from Si(p-C6H4CO2H)4 and Co(NO3)2

Keywords: Metal-Organic Framework, hydrogen storage, organosilicon, main-group elements. References:

1. R. P. Davies, R. J. Less, P. D. Lickiss, and A. J. P. White, Dalton Trans., 2007, 2528.

2. R.P. Davies, R. J. Less, P.D. Lickiss, K. Robertson, A. J. P. White, Inorg, Chem., 2008, 47, 9958.

3. R. P. Davies, R. Less, P. D. Lickiss, K. Robertson and A. J. P. White, Crystal Growth and Design, 2010, 10, 4571. 4. I. Timokhin, J. Baguña Torres, A. J. P. White, P. D. Lickiss, C. Pettinari, R. P. Davies, Dalton Transactions, 2013,

42, 13806; I. Timokhin, A. J. P. White, P. D. Lickiss, C. Pettinari, R. P. Davies, CrystEngComm, 2014, 16, 8094. 4. R. P. Davies, P. D. Lickiss, K. Robertson, and A. J. P. White, Aust. J. Chem., 2011, 64, 1237.

ENERGY-KN2

High Performance Polymeric Materials and Their Applications

Xu Li

Institute of Materials Research and Engineering, Agency for Science, Technology and Research, Singapore, 138634

Phone +65 6416 8933, E-Mail: x-li@imre.a-star.edu.sg

Abstract

In general, strategy for improving polymeric materials performance includes 1) design and synthesis of

novel structured polymers and 2) incorporation of functional inorganic filler into polymer matrix to form polymer

composites. Compared to polymer synthesis, fabrication of advanced polymer composites for various

applications is a straightforward and industry adoptable approach. In this talk, I will present research achievement

of our group on polymer composites development, including inorganic filler design and functionalization,

composite process and structure-property-performance relationship.

Inspired by the biosilification process of some marine organisms, we have successfully developed a

method to synthesize PEGylated silica nanocapsules, polymer composites at nanoscale, at room temperature and

near-neutral pH aqueous environment by using PEG-based block copolymer micelles as templates. The success

of this approach lies on confining silica shell growth at the interfacial area between core and corona of polymeric

micelles as a result of encapsulation of silica precursors inside the core of micelles. As a consequence, the

synthesized silica nanocapsules are intrinsically perforated by PEG chains, which enable them to exhibit

excellent colloidal stability and anti-fouling performance. The PEGylated silica nanocapsules are truly

nanosized, which are ~15 nm in diameter, and demonstrated to be non-cytotoxic. These silica nanocapsules can

be further functionalized by encapsulating hydrophobic ingredient inside their core.

Oxygen barrier of materials used to wrap food plays an important role in making sure the product reaches

consumer in the best possible condition. In order to enhance the oxygen barrier, layered-silicate fillers with high

aspect ratio such as montmorillonite (MTM) have been incorporated into plastic materials to form polymer

composites. Although the oxygen barrier of polymer matrix can be enhanced through incorporating

silicate fillers, various studies have shown that the maximal improvement on oxygen barrier with

layered-silicate/polymer composite fabricated through conventional compounding or mixing is about 2/3 in maximum.

At our group, a facile approach has been successfully developed for preparing flexible and optically transparent

hierarchical MTM polymer composite layer with excellent oxygen barrier through applying gelatinous MTM

polymer suspension onto PET film. Laminated flexible food packaging is then fabricated through laminating the

coated PET film with polyolefin film. Nano-structured Fe/carbon oxygen scavenging filler has developed for

further reducing oxygen transmission.

Keywords: Polymeric materials; Silica nanocapsules; Hierarchical polymer composites; Oxygen scavenging

filler.

ENERGY-KN3

Structural Design of Benzoxazine-derived Nanoporous Carbon

Electrodes for Energy Storage Devices

Thanyalak Chaisuwan

, Wilawan Sukponchaikul

, Peeranat

Jitwatcharakul

, Stephan T. Dubas

and Sujitra Wongkasemjit

1_{The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok}

10330

2_{Center for Petroleum, Petrochemicals, and Advanced Materials, Chulalongkorn}

University, Bangkok 10330

Phone +66 2218 4185, *_{E-Mail: thanyalak.c@chula.ac.th}

Abstract

In electrochemical energy storage devices, choosing the appropriate electrode materials could increase

the efficiency significantly. In this study, polybenzoxazines were chosen as precursors to prepare 3D –

interconnected nanoporous carbon. By varying different types of precursors and synthesis parameters,

nanoporous carbon with different microstructures can be obtained. In case of using phenol and

4,4-methylenedianiline based polybenzoxazine as a carbon precursor, it was found that polybenzoxazine with

surfactant added and CO

activation exhibited remarkable improvement in textural properties with the surface

area of 494 m

_{/g and the total pore volume of 0.81 cm}

_{/g. The relationship between the specific capacitance and}

pore structure of the carbon electrodes was investigated. The electrochemical measurement in 1.0 M H

SO

electrolyte showed that surfactant and CO

activation leaded to better capacitive performances with the specific

capacitance of 275.16 F/g at a scan rate of 1 mV/s. The presence of micropores are essential for electrolyte ions

adsorption, while the mesopores help to decrease the diffusive resistance of carbon electrodes and facilitate the

electrolye ions transportation.

Keywords: energy storage, electrode materials, nanoporous carbon, polybenzoxazine