Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands

The majority of studies presented in this thesis were performed at the Center for Human and Clinical Genetics of the Leiden University Medical Center (LUMC), Leiden, and

Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. Brodbeck J,

Surprisingly, in our present detailed assessment of spontaneous uniquantal ACh release and nerve stimulation-evoked release at the ex vivo NMJ of ducky, stargazer, and

Whereas neurotransmitter release at the neuromuscular junction was not affected in the conditional mice, homozygous deletion of the floxed allele caused an ablation of Ca v

However, experiments investigating granule cell synaptic transmission to stellate and basket cells (as well as their firing patterns) are needed to assess whether

We were not only able to prevent the early lethality seen in α1KO mice, but also could demonstrate that lack of Ca V 2.1 channel function in Purkinje cells is sufficient to

To allow for (indirect) detection of human mutated α 1A protein in mice that also express endogenous α 1A protein, enhanced green fluorescent protein (EGFP) reporter and the

Here, we present the generation and behavioral, electrophysiological, and neurobiological characterization of S218L knockin mice bearing the human pathogenic