Geometrical variability of esophageal tumors and its implications for accurate radiation therapy - List of publications; Portfolio; Curriculum vitae; Acknowledgments

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Geometrical variability of esophageal tumors and its implications for accurate

radiation therapy

Jin, P.

Publication date

2019

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Citation for published version (APA):

Jin, P. (2019). Geometrical variability of esophageal tumors and its implications for accurate

radiation therapy.

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Addendum

List of publications

Portfolio

Curriculum vitae

Acknowledgments

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List of publications

Peer reviewed scientific articles

M. Machiels, J.E. van Hooft, P. Jin, M.I. van Berge Henegouwen, H.M. van Laarhoven, T. Alder-liesten, and M.C.C.M. Hulshof. Endoscopy/EUS-guided fiducial marker placement in patients with

esophageal cancer: a comparative analysis of 3 types of markers. Gastrointestinal Endoscopy. 2015;

82(4):641–649.

P. Jin, A. van der Horst, R. de Jong, J.E. van Hooft, M. Kamphuis, N. van Wieringen, M. Machiels,

A. Bel, M.C.C.M. Hulshof, and T. Alderliesten. Marker-based quantification of interfractional tumor

position variation and the use of markers for setup verification in radiation therapy for esophageal can-cer. Radiotherapy and Oncology. 2015; 117(3):412–418.

P. Jin, M.C.C.M. Hulshof, R. de Jong, J.E. van Hooft, A. Bel, and T. Alderliesten. Quantification

of respiration-induced esophageal tumor motion using fiducial markers and four-dimensional computed tomography. Radiotherapy and Oncology. 2016; 118(3):492–497.

P. Jin, M.C.C.M. Hulshof, N. van Wieringen, A. Bel, and T. Alderliesten. Interfractional variability

of respiration-induced esophageal tumor motion quantified using fiducial markers and four-dimensional cone-beam computed tomography. Radiotherapy and Oncology. 2017; 124(1):147–154.

M. Machiels, P. Jin, C.H. van Gurp, J.E. van Hooft, T. Alderliesten, and M.C.C.M. Hulshof.

Com-parison of carina-based versus bony anatomy-based registration for setup verification in esophageal can-cer radiotherapy. Radiation Oncology. 2018; 13(48):1-9.

P. Jin, N. van Wieringen, M.C.C.M. Hulshof, A. Bel, and T. Alderliesten. Tailoring four-dimensional

cone-beam CT acquisition settings for fiducial marker-based image guidance in radiation therapy.

Jour-nal of Medical Imaging. 2018; 5(2): 021207.

P. Jin, K.F. Crama, J. Visser, N. van Wieringen, A. Bel, M.C.C.M. Hulshof, and T. Alderliesten.

Density override in treatment planning to mitigate the dosimetric effect induced by gastrointestinal gas in esophageal cancer radiation therapy. Acta Oncologica. 2018; In press.

P. Jin, M. Machiels, K.F. Crama, J. Visser, N. van Wieringen, A. Bel, M.C.C.M. Hulshof, and T.

Alderliesten. Dosimetric benefits of mid-position compared with internal target volume strategy for

esophageal cancer radiation therapy. International Journal of Radiation Oncology, Biology, Physics.

2018; In press.

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List of publications

M. Machiels, P. Jin, J.E. van Hooft, O.J. Gurney-Champion, P. Jelvehgaran, E.D. Geijsen, P.M. Jeene, M.W. Kolff, V. Oppedijk, C.R.N. Rasch, M.B. van Herk, T. Alderliesten, and M.C.C.M. Hulshof. Reduced inter-observer and intra-observer delineation variation in esophageal cancer

radio-therapy by use of fiducial markers. Submitted.

M. Machiels, F.E.M. Voncken, P. Jin, J. van Dieren, A. Bartels-Rutten, T. Alderliesten, J.E. van Hooft, and M.C.C.M. Hulshof. A novel liquid fiducial marker in esophageal cancer image-guided

ra-diotherapy: technical feasibility and visibility on imaging. Submitted.

Conference abstracts

P. Jin, M.C.C.M. Hulshof, M.A.J. de Jong, J.E. van Hooft, A. van der Horst, N. van Wieringen, M.

Machiels, A. Bel, and T. Alderliesten. PO-0877: First experience with the use of gold markers for

im-age guidance in esophim-ageal cancer radiotherapy. Radiotherapy Oncology. 2014; 111(Supplement

1):S94.

M. Machiels, J.E. van Hooft, T. Alderliesten, P. Jin, and M.C.C.M. Hulshof. Feasibility of

endo-scopic guided placement of markers in patients with esophageal tumors. International Journal of

Radi-ation Oncology, Biology, Physics. 2014; 90(1):S344.

P. Jin, M.C.C.M. Hulshof, R. de Jong, J.E. van Hooft, A. Bel, and T. Alderliesten. OC-0545:

Quan-tification of respiration-induced esophageal tumor motion using fiducial markers and 4D computed to-mography. Radiotherapy and Oncology. 2015; 115(Supplement 1):S263–S264.

M. Kamphuis, N. van Wieringen, P. Jin, T. Alderliesten, R. van Os, A. Bel, and M.C.C.M. Hul-shof. PO-1096: Inter-fraction variation of gas volume in the abdominal region during radiotherapy for

distal esophageal cancer. Radiotherapy and Oncology. 2015; 115(Supplement 1):S592–S593.

M. Machiels, P. Jin, C.H.M. van Gurp, J.E. van Hooft, T. Alderliesten, and M.C.C.M. Hulshof.

PV-0375: Comparison of carina- versus bony anatomy-based registration for IGRT in esophageal can-cer. Radiotherapy and Oncology. 2016; 119(Supplement 1):S175.

P. Jin, J. Visser, K.F. Crama, N. van Wieringen, A. Bel, M.C.C.M. Hulshof, and T. Alderliesten.

OC-0348: Reducing the dosimetric impact of variable gas volume in the abdomen during RT of esophageal cancer. Radiotherapy and Oncology. 2017; 123(Supplement 1):S184–S185.

P. Jin, M.C.C.M. Hulshof, N. van Wieringen, A. Bel, and T. Alderliesten. OC-0377: Limited

in-209

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List of publications

terfractional variability of respiration-induced tumor motion in esophageal cancer RT. Radiotherapy

and Oncology. 2017; 123(Supplement 1):S203–S204.

M. Machiels, P. Jin, P. Jelvehgaran, O.J. Gurney-Champion, E.D. Geijsen, P.M. Jenee, M.W. Kolff, V. Oppedijk, M.B. van Herk, T. Alderliesten, and M.C.C.M. Hulshof. PO-0697: Reduced inter- and

intra-observer variation in esophageal tumor delineation using fiducial markers. Radiotherapy and

On-cology. 2017; 123(Supplement 1):S279–S380.

P. Jin, M. Machiels, K.F. Crama, J. Visser, N. van Wieringen, A. Bel, T. Alderliesten, and M.C.C.M.

Hulshof. EP-1918: Dosimetric benefits of mid-position approach compared with internal target volume

for esophageal RT. Radiotherapy and Oncology. 2018; 127(Supplement 1):S1042–S1043.

Conference proceedings

P. Jin, N. van Wieringen, M.C.C.M. Hulshof, A. Bel, and T. Alderliesten. 4D cone-beam CT imaging

for guidance in radiation therapy: setup verification by use of implanted fiducial markers. Proceedings

of SPIE 9786 Medical Imaging 2016; Image-Guided Procedure, Robotic Interventions, and Mod-eling 9786:97862N.

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Portfolio

Name Peng Jin

PhD period October 2013 – December 2017

Department Radiation Oncology

Promoter Prof. dr. C.R.N. Rasch

Copromoters Dr. T. Alderliesten Dr. M.C.C.M. Hulshof

PhD training Year ECTS

General courses

The AMC World of Science 2013 0.7

Scientific Writing in English for Publication 2014 1.5

Practical Biostatistics 2014 1.1

Specific courses

OOA Course Radiation Oncology 2014 1.5

NVRO and NVKF Course MRI in Radiotherapy 2014 1.5

ESTRO Course Basic Treatment Planning 2014 1.5

ESTRO Pre-meeting Course 4D Radiotherapy 2015 0.4

ESTRO Imaging Course for Physicists 2015 1.5

ImagO Course Imaging Processing 2016–2017 6.0

International conferences

ESTRO 33, Vienna, Austria 2014 1.0

ESTRO 3rd Forum, Barcelona, Spain 2015 1.0

SPIE Medical Imaging, San Diego, USA 2016 1.25

ESTRO 36, Vienna, Austria 2017 1.0

National and regional scientific events

OOA PhD Student Retreats 2014–2015 2.0

Scientific Days for Radiotherapy Physicists 2013–2017 1.5 Amsterdam Regional Radiotherapy Evening Lectures 2014–2017 0.5

NVRO Scientific Meeting 2015 0.25

Amsterdam iQ Signaallezing Lectures 2016 0.1

Utrecht Esophageal Cancer Symposium 2016 0.25

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Portfolio

Institutional scientific meetings

Department Medical Physicist Meetings 2013–2017

Department Multidisciplinary Meetings 2013–2017

Multidisciplinary Meetings of Esophageal Cancer Research 2013–2017

Spinoza lectures 2014–2017

Presentations

First experience with the use of fiducial markers for image guidance in esophageal cancer radiotherapy – Oral presentation at the

Multidisciplinary Meeting, Department of Radiation Oncology, AMC, the Netherlands

2014

First experience with the use of gold markers for image guidance in esophageal cancer radiotherapy – Poster presentation at ESTRO 33, Vienna, Austria

2014 0.5

Study of tumor motion using markers in image-guided radiotherapy for esophageal cancer – Oral presentation at the Medical Physicist Meeting,

Department of Radiation Oncology, AMC, the Netherlands

2014

Overview of motion study using fiducial markers in esophageal cancer image-guided radiotherapy – Oral presentation at the Scientific Day for

Radiotherapy Physicists, UMCU, the Netherlands

2014 0.5

First experience with the use of gold markers for image guidance in esophageal cancer radiotherapy– Poster presentation at the OOA PhD Student

Retreat, Renesse, the Netherlands

2014 0.5

Quantification of respiration-induced tumor motion in radiation therapy of esophageal cancer – Oral presentation at the Multidisciplinary Meeting of

Esophageal Cancer Research, AMC, the Netherlands

2015 0.5

Quantification of respiration-induced esopheageal tumor motion using fiducial markers and 4D computed tomography – Oral presentation at the

OOA PhD Student Retreat, Renesse, the Netherlands

2015 0.5

Quantification of respiration-induced esopheageal tumor motion using fiducial markers and 4D computed tomography – Oral presentation at

ESTRO 3rd Forum, Barcelona, Spain

2015 0.5

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Portfolio

The use of markers for quantification of interfractional tumor position variation and setup verification for esophageal cancer radiotherapy – Oral

presentation at NVRO Scientific Meeting, Amersfoort, the Netherlands

2015 0.5

Interfractional variation of respiration-induced esophageal tumor motion quantified by use of 4D-CBCT – Oral presentation at the Multidisciplinary

Meeting, Department of Radiation Oncology, AMC, the Netherlands

2015

4D cone-beam CT imaging for guidance in radiation therapy: setup verification by use of implanted fiducial markers – Poster presentation at

SPIE Medical Imaging, San Diego, USA

2016 0.5

Dosimetric impact of variable gas volume in the abdominal region for esophageal cancer radiotherapy – Oral presentation at the

Multidisciplinary Meeting, Department of Radiation Oncology, AMC, the Netherlands

2016

Limited interfractional variability of respiration-induced tumor motion in esophageal cancer RT – Oral presentation at ESTRO 36, Vienna, Austria

2017 0.5

Reducing the dosimetric impact of variable gas volume in the abdomen during RT of esophageal cancer – Oral presentation at ESTRO 36, Vienna,

Austria

2017 0.5

Can a density override planning strategy mitigate the dosimetric impact of variable volume of gastrointestinal gas pockets for esophageal cancer radiotherapy? – Oral presentation at the Scientific Day for Radiotherapy

Physicists, UMCU, the Netherlands

2017 0.5

Dosimetric benefits of mid-position approach compared with internal target volume for esophageal RT. Radiotherapy and Oncology – Poster

presentation at ESTRO 37, Barcelona, Spain

2018 0.5

Teaching and supervising Year ECTS

A. Gonçalves, Graduation Internship, bachelor student from University of Lisbon, Portugal

2014 1

N. van Rijn, Graduation Project, bachelor student of Medische Beeldvorming en Radiotherapeutische Technieken from Fontys Paramedische Hogeschool, the Netherlands

2016 1

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Portfolio

Parameters of esteem Year

ESTRO-ACCURAY Award – Limited interfractional variability of

respiration-induced tumor motion in esophageal cancer RT

2017

Chinese Government Award for Outstanding Self-financed Students Abroad

2017

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Curriculum vitae

Peng Jin was born on 16 February, 1989 in Jinan, Shandong, China. He attended the Shandong Experimental High School in Jinan and graduated in 2007. In the same year he started his bach-elor program Communication Engineering at the School of Information Science and Engineering in Shandong University ( Jinan, China). One year later he started the second bachelor program

Finance at the School of Economics in Shandong University. After a short stay at the University of

Ulm (Ulm, Germany) in 2011, Peng finished his bachelor theses and received the bachelor diplo-mas. Meanwhile, he was awarded the University of Twente Scholarship and started his master program Electrical Engineering in the fall of 2011 at the faculty of Electrical Engineering Mathe-matics and Computer Science in the University of Twente (Enschede, the Netherlands). In 2013, Peng finished his master thesis in the group of Signals and Systems in the University of Twente, in collaboration with DEMCON (Enschede, the Netherlands) and the department of Radiology in the Radboud University Medical Center (Nijmegen, the Netherlands). After graduation, Peng became a PhD student at the department of Radiation Oncology in the Amsterdam University Medical Centers at the location Academic Medical Center (Amsterdam, the Netherlands). The PhD project resulted in this thesis entitled Geometrical variability of esophageal tumors and its

im-plications for accurate radiation therapy. Since January 2018, Peng has been working in Holland

Proton Therapy Center (Delft, the Netherlands) as a project physicist.

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Acknowledgments

Coen, thank you for being my promotor. All the critical reviews and insightful suggestions are of

tremendous help to me. You’ve created such a nice and harmonious atmosphere and benefited all the PhD students in our department.

My committee members, thank you all for the time to evaluate my thesis. Although we did not work together, I learned and was inspired a lot from your works. I would like to wish for any possibility and privilege to work with you in the future.

Tanja, thank you for bringing me into the scientific world of radiation therapy. Without your

daily guidance and mentoring, I could not have steered my PhD project so well. You were always inspiring and your advices were always perceptive. Your meticulousness about everything nudged me to pursue perfection. It is a great honor for me to work with you and I truly enjoyed. Further-more, you’ve shared with me your life moments and you’ve always been there whenever I was in need. Thank you! You’ve made me feel home.

Maarten and Arjan, thank you for constantly contributing your expertise to the project. Your

intellectual acuity helped to fix loads of deficiencies and problems in the project. It was marvelous to work with you.

Mélanie, Jeanin, Jorrit, Niek, Koen, and Rianna, the core members in my PhD project. It

was a team effort to achieve our research objectives and you might have not realized how much I learned from each one of you. I am very grateful for your hard work and timely assistance. Astrid and Anette, I would like to give my special thanks to you for leading me at the beginning stage of my PhD. You’ve made things easy and allowed me to have a smooth start. Lukas, Debby, Hans,

Petra, and Irma, thank you for sharing with me your knowledge. Every piece of your advices

helped a lot to promote the research.

I would like to thank all the radiation oncologists and radiation oncology residents for your attention, as well as the valuable input, during my presentations. I would like to thank the physics group (all medical physicists, KLIFIOs, KFMers, RTTs, and technicians) and the ICT group for the prompt technical support you’ve offered during the data collection and analyses. I would also like to thank our secretaries for aids on the documentations, the arrangement of my promotion, and my applications for the residence permit.

My lovely roommates and (ex-)colleagues, you made my daily life wonderful and I always felt warm and relaxed at work. Anna, Eelco, Stijn, Oliver, Remy, Lotte, and Edmond, thank you very much for sharing your experiences with me and spending time answering various kinds of questions at the beginning of my PhD life. You were all great role models and showed me how to pave the way to be a successful scientist. Gerben, for many times, you had to put aside your own work and helped me out with the image conversion script. You have saved a lot of time for me. Thank you very much. Caspar, I would like to express my gratitude to you for your spending time on all my drop-by questions. You helped me magnificently on the statistical models. There was

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Acknowledgments

no way to have those articles accepted without your efforts. Laura and Kleopatra, we started our PhD programs at the same time and I feel grateful to go through this once of a lifetime experience together with you. Stef and Sophie, we’ve spent much quality time together, the drinks, dinners, parties, and conferences. I would never forget those super memories. Pouya, Marco, Ziyuan, and

Pierre, thank you for being part of my PhD life. Talking with you has largely enriched my thought

and view. Coen, Marjolein, Janna, Anton, Hoang, Daan, and Margot, meeting with you was always delightful. I found the department a very sweet place on my occasional visits. Thanks! I wish you all the best.

My colleagues in HollandPTC, Mischa, Petra, Pieternel, Yibing, Joan, Steven, Anna, Jérémy,

Hansjörg, Paul, Laura, Marjan, and Franciska, you have taught me considerable knowledge of

proton therapy and made me confident in writing the corresponding part of this thesis. Thank you for all the helps. Charlotte and Charlotte, it is nice to share the same office with you and we have great time together. Thank all the RTT and ICT groups for the shared expertise and the offered helps. It’s lucky to work with all of you.

Zhengyang, Jiapeng, Xi, He, Qian, and Yue, my fantastic roommates in high school, I would

like to express big gratitude to you for your longtime and unconditional love. We met in our teenage years and have never stopped supporting one another since then. You are like my broth-ers. We are now all spread around the world, I miss you very much and I cannot wait to meet you soon. Yong, Long, Pengfei, Zixiao, Xue, Qingyu, Pengcheng, Shuaishuai, Wenjia, and

Xi-angying, thank you for the warm hospitality every time I visited your cities. No less amount of

thanks should be given to my friends in Jinan, Qi, Xin, Long, and Yubing, it was always amazing to chill out with you at hometown.

My friends in Europe, Lu, Xiaochen, Yihan, and Tommy, without you my life here could not have been so fabulous. I had the best time with you in recent years. We have been traveling around the world together and created so many memories. Embraced by your care and support, I never felt lonely. Thank you! Jort and Björn, thank you for sharing your life moments, teaching me new stuffs, and helping me with language. Fangjie, Xichen, Yujie, Xiaomeng, Shu, Kai, Yuanyuan,

Kai, Yin, Xu, Na, Hequn, Yi, Wei, Yingying, Yu, Song, Longquan, Difeng, Meiru, Zhao, Liang,

and Zhen, I feel so lucky to meet you in my life. Thank you for all the time together.

Last but not least, I would like to express my full-hearted gratitude to my family. Your support and love are always my motivation to accomplish my PhD and this book is dedicated to you. Thank you all for your cares and understanding. I wish you all the best.