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Focal therapy
Changing the landscape of prostate cancer treatments
Scheltema, M.J.V.
Publication date
2018
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Citation for published version (APA):
Scheltema, M. J. V. (2018). Focal therapy: Changing the landscape of prostate cancer
treatments.
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F O C A L T H E R A P Y
Changing the Landscape of Prostate Cancer Treatments
Matthijs J.V. Scheltema
FOCAL
THERAPY
Changing the Landscape of Pr
ostate Cancer
Treatment
s
Matthijs J.V
. Scheltema
U IT N O D I G I N Gtot het bijwonen van de openbare verdediging van het proefschrift
F O C A L
T H E R A P Y
Changing the Landscape of
Prostate Cancer Treatments
door
Matthijs J.V. Scheltema
op vrijdag 25 mei 2018 om 10.00 uur in de Agnietenkapel van de Universiteit van Amsterdam, Oudezijds Voorburgwal 231
1012 EZ Amsterdam Aansluitend bent u van harte welkom op de receptie ter plaatse
PA R A N I M F E N Nienke Scheltema nienkemarije@hotmail.com Mara Buijs m.buijs@amc.uva.nl M AT T H I J S S C H E LT E M A Eerste Atjehstraat 29-2 1094 KA Amsterdam matthijsscheltema@hotmail.com 15160-scheltema-cover.indd 1 03/04/2018 11:56
F O C A L T H E R A P Y
Changing the Landscape of Prostate Cancer Treatments
COLOFON
Layout & cover design: Design Your Thesis, www.designyourthesis.com Printing: Ridderprint BV, www.ridderprint.nl
ISBN: 978-94-6299-961-9
The research projects in this thesis were performed in collaboration with the following departments;
• Urology, Academic Medical Center, Amsterdam,
• Biomedical Engineering and Physics, Academic Medical Center, Amsterdam • Garvan Institute of Medical Sciences, Sydney, Australia
• St. Vincent’s Prostate Cancer Center, Sydney, Australia
Work in this thesis was funded by the Cure for Cancer Foundation, the Australian Prostate Cancer Research Centre and the Australian Commonwealth Department of Health Personal grants for the conduct and printing of this thesis were provided by AngioDynamics, the Cure for Cancer Foundation, Astellas, Ipsen, Bayer, Zambon, Pfizer, Ferring, Chipsoft B.V. and the Academic Medical Center.
FOCAL THERAPY:
CHANGING THE LANDSCAPE OF PROSTATE
CANCER TREATMENTS
A C A D E M I S C H P R O E F S C H R I F T
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus
prof. dr. Ir. K.I.J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel
op vrijdag 25 mei 2018, te 10.00 uur
door
Matthijs Jan Valentijn Scheltema
PROMOTIECOMMISSIE
Promotores: Prof. dr. J.J.M.C.H. de la Rosette AMC-UvA Prof. dr. M.P. Laguna AMC-UvA Copromotores: Dr. T.M. de Reijke AMC-UvA Dr. D.M. de Bruin AMC-UvA
Overige leden: Prof. dr. R.J.A. van Moorselaar Vrije Universiteit Amsterdam Prof. dr. ir. M.J.C. van Gemert AMC-UvA
Prof. dr. A.G.J.M. van Leeuwen AMC-UvA Prof. dr. C.J.A. Punt AMC-UvA Prof. dr. O.M. van Delden AMC-UvA Prof. dr. M.G.H. Besselink AMC-UvA Dr. M.R. Meijerink VUmc Faculteit der Geneeskunde
5
TABLE OF CONTENTS
Chapter 1 General introduction & aims of thesis 9
Chapter 2 Utilization of multiparametric prostate magnetic resonance imaging in clinical practice and focal therapy: report from a Delphi consensus project
45
Chapter 3 Preliminary diagnostic accuracy of multiparametric magnetic resonance imaging to detect residual
prostate cancer following focal therapy with irreversible electroporation
65
Chapter 4 Irreversible electroporation for the treatment of localized prostate cancer: a summary of imaging findings and treatment feedback
83
Chapter 5 Focal irreversible electroporation as primary treatment for localized prostate cancer
99
Chapter 6 Impact on Genito-Urinary Function and Quality of Life following Focal Irreversible Electroporation of Different Prostate Segments
119
Chapter 7 Feasibility and safety of focal irreversible electroporation as salvage treatment for localized radio-recurrent prostate cancer
137
Chapter 8 Pair-matched Patient-reported Quality of Life following Focal Irreversible Electroporation versus Robot-Assisted Radical Prostatectomy; an alternative approach to study outcomes of a new prostate cancer treatment
155
Chapter 9 Focal vs extended ablation in localized prostate cancer with irreversible electroporation; a multi-center randomized controlled trial.
173
Chapter 10 Concluding remarks and future perspectives 193
6
Supplements Author contributions 217 AMC graduate school PhD portfolio 221 List of publications 223 Curriculum Vitae 229 Acknowledgements/Dankwoord 231
