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Familial atherosclerosis and neuroimmune guidance cues
From in vitro assessments to clinical events
Bruikman, C.S.
Publication date
2020
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Citation for published version (APA):
Bruikman, C. S. (2020). Familial atherosclerosis and neuroimmune guidance cues: From in
vitro assessments to clinical events.
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From in vitro assessments to clinical events
Caroline Bruikman
Familial Atherosclerosis and
Neuroimmune Guidance Cues
FAMILIAL A
THEROSCLEROSIS AND NEUROIMMUNE GUID
Familial Atherosclerosis and
Neuroimmune Guidanc Cues
from in vitro assessments to clinical events
Familial Atherosclerose and
Neuroimmune Guidance Cues
from in vitro assessments to clinical events
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen
op vrijdag 26 juni 2020, te 14.00 uur door Caroline Suzanne Bruikman
geboren te Zeist Copyright © 2020, C.S. Bruikman, Amsterdam, The Netherlands
No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without prior written permission of the author. ISBN: 978-94-6375-885-7
Author, Layout and Cover design: Caroline Bruikman Printing: Ridderprint, www.ridderprint.nl
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
Financial support for printing this thesis was kindly provided by the University of Amsterdam, Chipsoft and Stichting tot Steun Promovendi Vasculaire Geneeskunde.
PROMOTIECOMMISSIE
Promotor: prof. dr. G.K. Hovingh AMC-UvA
Copromotor: dr. J.M. van Gils Leids Universitair Medisch Centrum Overige leden: dr. V.E.A. Gerdes AMC-UvA
dr. M.R.M. Jongbloed Leids Universitair Medisch Centrum prof. dr. ir. J.A. Kuivenhoven Rijksuniversiteit Groningen
prof. dr. E. Lutgens AMC-UvA prof. dr. M.M.A.M. Mannens AMC-UvA prof. dr. Y.M. Pinto AMC-UvA prof. dr. C.J.M. de Vries AMC-UvA Faculteit der Geneeskunde
TABLE OF CONTENTS
CHAPTER 1 General introduction and outline of the thesis 9
PART I THE ROLE FOR NEUROIMMUNE GUIDANCE CUES IN
ATHEROSCLEROSIS
CHAPTER 2 Understanding netrins in endothelial cell biology 19 CHAPTER 3 Eph receptor B2 stimulates human monocyte
adhesion and migration independently of its ephrinB ligands
35 CHAPTER 4 Downregulation of endothelial PLXNA4 under
pro-atherosclerotic conditions diminishes vascular integrity
63 CHAPTER 5 Netrin-1 and the grade of atherosclerosis are
inversely correlated in humans 85
CHAPTER 6 Netrin-1 in coronary artery disease: Mechanism of
action and potential as therapeutic target 117
PART II FAMILY BASED APPROACH OF PREMATURE
ATHEROSCLEROSIS
CHAPTER 7 The identification and function of a Netrin-1 mutation in a pedigree with premature atherosclerosis
127 CHAPTER 8 Sudden cardiac death in families with premature
cardiovascular disease 155
CHAPTER 9 Summary and future perspectives 169
APPENDICES
Nederlandse samenvatting 183
Co-authors and affiliations 187
PHD portfolio 188
Dankwoord 193
About the author 196
Nawoord 197
