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University of Groningen

The effects of oxytocin in autism

Groen, Yvonne; Althaus, Monika ; Oosterhoff, Menno; Balkom, van, Ingrid D. C.; Hoekstra,

Pieter J.

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Groen, Y., Althaus, M., Oosterhoff, M., Balkom, van, I. D. C., & Hoekstra, P. J. (2019). The effects of

oxytocin in autism. Poster session presented at 19e Nationaal Autisme Congres, Rotterdam, Netherlands.

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(2)

Yvonne Groen

1

, Monika Althaus

2

, Menno Oosterhoff

3

, Ingrid D.C. van Balkom

3

, Pieter J. Hoekstra

2

1 University of Groningen, Department of Clinical and Developmental Neuropsychology

2 University of Groningen, University Medical Center Groningen, Department of Child- and Adolescent Psychiatry 3 Autism Team Northern-Netherlands, Jonx of Lentis Psychiatric Institute

Autism Spectrum Disorder is …

A lifelong developmental disorder

Characterized by deficits in social interaction and

communication, and restricted interests and

behavior patterns

Associated with altered social cognition and

emotion processing

Oxytocin nasal

spray improves

affective

empathy in a

select group of

males with

autism

Objective

A randomized controlled

cross-over trial with oxytocin nasal

spray (one dose of 24 EU) was

conducted to investigate

effects of oxytocin in young

adult males with autism.

neutral

positive

negative

humans

scenes

Oxytocin is …

Produced in the

hypothalamus

A hormone influencing

a.o. digestion and sex

organs

A neurotransmitter

influencing social

cognition and emotion

processing

Involved in calm, healing

and love

E-mail: y.groen@rug.nl

Sensitivity to distress of others,

example items from the IRI:

“I sometimes feel helpless when

I am in the middle of a very

emotional situation”

“When I see someone who

badly needs help in an

emergency, I go to pieces”

Oxytocin enhances

brain responses to

positive emotions in

humans in males with

autism having:

high sensitivity to

distress of others

high pre treatment

oxytocin blood

levels

Brain responses (EEG) to

emotions in humans

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