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Surface Curvature Differentially Regulates Stem Cell Migration and Differentiation via Altered Attachment Morphology and Nuclear Deformation

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Copyright WILEY-VCH Verlag GmbH & Co. KGaA, 69469 Weinheim, Germany, 2016.

Supporting Information

for Adv. Sci., DOI: 10.1002/advs.201600347

Surface Curvature Differentially Regulates Stem Cell

Migration and Differentiation via Altered Attachment

Morphology and Nuclear Deformation

Maike Werner, Sébastien B. G. Blanquer, Suvi P. Haimi,

Gabriela Korus, John W. C. Dunlop, Georg N. Duda, Dirk. W.

Grijpma, and Ansgar Petersen*

(2)

1 Supporting Information

Figure S1: Mean hMSC migration speed on various curvature magnitudes. The mean hMSC migration speed over 24 hours on a flat surface and on concave and convex spherical surfaces of various curvature magnitudes. Mean +/- 95% CI.

Movie S1: Time lapse recording of migrating hMSCs.

Movie S2: hMSCs adopt a spider-like morphology on concave spherical surfaces.

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