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Biology of monocyte interactions with the endothelium : the platelet factor
da Costa Martins, P.A.
Publication date
2005
Link to publication
Citation for published version (APA):
da Costa Martins, P. A. (2005). Biology of monocyte interactions with the endothelium : the
platelet factor.
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Thee author of this thesis was born in Maputo, Mozambique, on the 5 of May of 1976. Fromm 1987 to 1993 she attended the Jorge Peixinho Highschool, in Montijo, Portugal. In 19933 she began her studies in Biology, at the Faculty of Sciences of the University of Lisbon, Soonn she became interested in the world of Biotechnology and Molecular Biology and from 19955 till 1998 she worked as a student at the Department of Plant Biotechnology at the InstituteInstitute for Applied Sciences and Technology in Lisbon. During this period she collaborated inn a PhD project under the supervision of Dr. A. Balde and Prof. S. Pais. In 1998 she did her traineeshipp at the Department of Genetics at the Free University, in Amsterdam, The Netherlands,, under the supervision of Dr. D. Roelofs and Dr. J. Kooter. She obtained her Masterr of Science degree in Biology in September, 1998. Her interest in Plant Biotechnology ledd her to accept a short-term job working as a researcher at the CPRO-DLO in Wageningen. Inn 1999, she returned to Portugal where she worked as a researcher at the Department of Plantt Biotechnology at the Institute for Applied Sciences and Technology in Lisbon, until 2000.. In April 2000 she moved to Amsterdam to begin her PhD research at the Department off Lung Diseases at the University Medical Centre in Utrecht, under the supervision of Dr. JJ Zwaginga.. One year later, the group moved to the Sanquin Research, in Amsterdam, where shee continued her work at the Department of Immunohematology under the supervision of Dr.. J.J. Zwaginga and Prof. D. Roos.
Inn April 2005 she has started her first post-doctoral research at the Departments of Immunohematologyy and Molecular Cell Biology under the supervision of Dr. E. van der Schoot,, Dr. P. Hordijk and Dr. J.J. Zwaginga.
Curriculumm vitae
Listt of Publications
1.. Assuncao, A. G. L, Costa Martins. P.. De Folter, S., Vooijs, R., Schat, H., and Aarts, M. G.. M. (2001) Elevated expression of metal transporter genes in three accessions of the metall hyperaccumulator Thlaspi caerulescens. Plant Cell Environ 24: 217-226.
2.. da Costa Martins P, van den Berk N, Ulfman LH, Koenderman L, Hordijk PL, Zwaginga JJ. Platelet-monocytee complexes support monocyte adhesion to endothelium by enhancing secondaryy tethering and cluster formation. Arterioscler Thromb Vase Biol. 2004 Jan;24(1):193-9.. Epub 2003 Nov 13.
3.. Spijkers PP, da Costa Martins P. Westein E, Gahmberg CG, Zwaginga JJ, Lenting PJ. LDL-receptor-relatedd protein regulates beta2-integrin-mediated leukocyte adhesion. Blood. 20055 Jan 1;105(1): 170-7. Epub 2004 Aug 24.
4.. da Costa Martins P. van Gils J, Hordijk PL, Zwaginga JJ. Platelet binding to monocytes increasess the adhesive properties of monocytes by upregulating the expression and functionalityy of betai and beta2 integrins. Submitted for publication.
5.. da Costa Martins P. Garcia-Vallejo JJ, van Thienen JV, Femandez-Borja M, Horrevoets AJ,, Hordijk PL, Zwaginga JJ. P-selectin glycoprotein ligand-1 (PSGL-1) is expressed on endotheliall cells and mediates monocyte adhesion to activated endothelium. Submitted for publication. .
6.. Garcia-Vallejo JJ, van Liempt E, da Costa Martins P. Beckers C, van het Hof B, Gringhuis SI,, Zwaginga JJ, van Dijk W, Geitenbeek TBH, van Kooyk Y, van Die I. DC-SIGN mediates adhesionn and rolling of dendritic cells on primary human umbilical vein endothelial cells throughh LewisY antigen expressed on ICAM-2. Manuscript in preparation.
7.. Rouschop K, Roelofs JJ, Claessen N, da Costa Martins P. Zwaginga JJ, Pals ST, Weeningg JJ, Florquin S. Protection against Renal Ischemia Reperfusion Injury by CD44 Disruption.. J Am Soc Nephrol. 2005 May 18.
