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Stepping into the RING: preclinical models in the fight against hereditary breast
cancer
Drost, R.M.
Publication date
2012
Link to publication
Citation for published version (APA):
Drost, R. M. (2012). Stepping into the RING: preclinical models in the fight against hereditary
breast cancer. Het Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis.
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Abbreviations
5-FU 5-fluorouracil
aa amino acids
ABC ATP-binding cassette
aCGH array comparative genomic hybridization ATM ataxia-telangiectasia mutated
BAC bacterial artificial chromosome
BACH1 BRCA1-interacting protein C-terminal helicase 1 BARD1 BRCA1-associated RING domain protein 1 BER base excision repair
BIC breast cancer information core
BLG beta-lactoglobin
BrdU bromodeoxyuridine
CK cytokeratin
CNA copy number aberration
COBRA-FISH combined binary ratio labelling-fluorescence in situ hybridization
CtIP CtBP-interacting protein 1
DDR DNA damage response
DOPPCR degenerate-oligonucleotide priming polymerase chain reaction DSB double-strand break DZNep 3-deanzaneplanocin A E embryonic day ER estrogen receptor ES embryonic stem FA fanconi anaemia
FA-N fanconi anaemia subtype N FA-D1 fanconi anaemia subtype D1
GEMM genetically engineered mouse model H3-K27me3 histone H3 lysine 27 trimethylation HBOC hereditary breast and ovarian cancer
HER2 human epidermal growth factor receptor type 2
HR homologous recombination
HRD homologous recombination deficiency
HU hydroxyurea
ICL interstrand crosslink IDC invasive ductal carcinoma
IR ionizing radiation
IRIFs irradiation-induced foci KB1(185stop)P K14cre;Brca1F/185stop;p53F/F
KB1(5382stop)P K14cre;Brca1F/5382stop;p53F/F
KB1C61GP K14cre;Brca1F/C61G;p53F/F
KB1P K14cre;Brca1F/F;p53F/F
KB2P K14cre;Brca2F/F;p53F/F
LIF leukaemia inhibitory factor LOH loss of heterozygosity mESCs mouse embryonic stem cells
MMC mitomycin C
MMR mismatch repair
MMS methylmethane sulphonate MMTV mouse mammary tumor virus MTD maximum tolerable dose NER nucleotide excision repair NES nuclear export sequence NLS nuclear localization signal NMD nonsense-mediated mRNA decay
OS overall survival
PALB2 partner and localizer of BRCA2 PARP poly(ADP-ribose) polymerase-1 PDX patient-derived xenograft PI3K phospho-inositol-3 kinase
PR progesterone receptor
PRC2 polycomb repressive complex 2
RMCE recombinase-mediated cassette exchange
SCD SQ/TQ cluster domain
SCE sister chromatid exchange
SCM stem cell medium
shRNA short hairpin RNA SKY spectral karyotyping
SNP small nucleotide polymorphism
SRB sulforhodamine B
SSB single-strand break
ssDNA single-stranded DNA
TFS tumor-free survival
TNBC triple negative breast cancer
TSA trichostatin A
