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Tracing tremor: Neural correlates of essential tremor and its treatment
Buijink, A.W.G.
Publication date
2016
Document Version
Final published version
Link to publication
Citation for published version (APA):
Buijink, A. W. G. (2016). Tracing tremor: Neural correlates of essential tremor and its
treatment.
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Arthur W.G. Buijink
Neural correlates of essential tremor
and its treatment
TRACING
TREMOR
Tracing
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.G. Buijink
Tracing tremor
Neural correlates of essential tremor
and its treatment
This thesis was prepared at the Department of Neurology and Clinical Neurophysiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Work for chapters 3, 4, 5, 6 and 8 was supported by grants from the Prinses Beatrix Fonds (W.OR10-01) and the Hersenstichting Nederland (2012(1)-91). Work for chapter 9 was performed using the e-bioinfra platform developed at the e-bioscience group of the Bioinformatics Laboratory of the AMC, using resources of the Dutch e-Science Grid, BiGGrid project, which is financially supported by the Netherlands Organisation for Scientific Research (NWO).
The authors report no conflicts of interest.
Printing of this thesis was financially supported by the AMC Graduate School, the Department of Neurology of the AMC, Stichting Wetenschapsfonds Dystonie and the Benelux Neuromodulation Society.
Printed by Ipskamp Drukkers, Enschede, the Netherlands
Cover design and illustration by Tessa de Römph and Arthur Buijink ISBN 978-94-6259-788-4
Copyright 2015 Arthur W.G. Buijink, Amsterdam. No parts of this thesis may be reproduced, stored or transmitted in any form or by any means without the prior permission of the author or publishers of the included scientific papers.
Tracing tremor
Neural correlates of essential tremor
and its treatment
ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam op gezag van de Rector Magnificus
prof. dr. D.C. van den Boom
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel
op vrijdag 29 januari 2016, te 14.00 uur door Arthur Willem Gerard Buijink
Promotiecommissie
Promotor: prof. dr. I.N. van Schaik Universiteit van Amsterdam Copromotor: dr. A.F. van Rootselaar Universiteit van Amsterdam Overige leden: prof. dr. H.W. Berendse Vrije Universiteit
prof. dr. C.B.L.M. Majoie Universiteit van Amsterdam prof. dr. Y.B.W.E.M. Roos Universiteit van Amsterdam prof. dr. C.I. de Zeeuw Erasmus Universiteit Rotterdam dr. J.H.T.M. Koelman Universiteit van Amsterdam dr. ir. A.J. Nederveen Universiteit van Amsterdam Faculteit der Geneeskunde
Contents
1. General introduction and aims... 9 2. How to tackle tremor – systematic review of the literature and
diagnostic work-up... 23
Front. Neurol. 2012 Oct;3(146):1-12.
Part I: neural correlates of essential tremor
3. Bilateral cerebellar activation in unilaterally challenged essential tremor ... 47 4. Motor network disruption in essential tremor, a functional and
effective connectivity study ... 67
Brain 2015. In press.
5. Rhythmic finger tapping reveals cerebellar dysfunction in essential tremor ... 101
Parkinsonism Relat. Disord. 2015 Apr;21(4):383-388.
6. Cerebellar atrophy in cortical myoclonic tremor and not in hereditary essential tremor – a voxel-based morphometry study ... 119 7. Decreased cerebellar fiber density in cortical myoclonic tremor but
not in essential tremor ... 137
Cerebellum 2013 Apr;12(2):199-204.
Part II: neural correlates of treatment of essential tremor
8. Propranolol in essential tremor affects motor control in a pattern fitting increased Renshaw inhibition ... 149 9. Structural changes in cerebellar outflow tracts after thalamotomy in
essential tremor ... 169
Parkinsonism Relat. Disord. 2014 May;20(5):554–557.
Nederlandse Samenvatting ... 195 References...202 Abbreviations ... 219 Contributing authors... 220 PhD Portfolio ... 223 List of publications ... 228 Dankwoord. ... 230 Curriculum vitae ... 232
