Characterization of the innate and adaptive immune systems during active TB disease and during treatment

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(2) Stellenbosch University https://scholar.sun.ac.za. Declaration. By submitting this dissertation electronically, I declare that the entirety of the work contained therein is my own, original work, that I am the sole author thereof (save to the extent explicitly otherwise stated), that reproduction and publication thereof by Stellenbosch University will not infringe any third party rights and that I have not previously in its entirety or in part submitted it for obtaining any qualification.. Signature: .......��:......................... Date: ... /?J.J�/?.'?.!J ......

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(12) Stellenbosch University https://scholar.sun.ac.za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aL>DQL@=FJMF $>QGM;9FaLJMFL@=FO9DC $>QGM;9FaLO9DCL@=F;J9OD ML:Q9DDE=9FKC==HEGNAF? %1AC9=$DC85A#9=7"A. . NAA.

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