2.8 Supplemental material
2.8.1 S1 Reasons for study exclusionAuthor Year Title Reason for exclusion
Amin 2004 Attentional bias for valenced stimuli as a function of
personality in the dot-probe task Incorrect contrast Brück 2011 Impact of personality on the cerebral processing of
emotional prosody Incorrect contrast
Canli 2001 An fMRI study of personality influences on brain
reactivity to emotional stimuli Incorrect contrast Chan 2009 Risk for depression and neural responses to fearful facial
expressions of emotion Incorrect contrast
Cunningham 2011 Reprint of: Aspects of neuroticism and the amygdala:
chronic tuning from motivational styles Incorrect contrast Cunningham 2010 Aspects of neuroticism and the amygdala: chronic tuning
from motivational styles Incorrect contrast
Demoto 2012 Neural and personality correlates of individual differences related to the effects of acute tryptophan depletion on future reward evaluation
Substance administration
Di Simplicio 2011 Short-term antidepressant administration reduces negative self-referential processing in the medial prefrontal cortex in subjects at risk for depression
Substance administration
Drabant 2011 Experiential, autonomic, and neural responses during threat anticipation vary as a function of threat intensity and neuroticism
Incorrect contrast
Feinstein 2006 Anterior insula reactivity during certain decisions is
associated with neuroticism Incorrect contrast
Fischer 1997 Extraversion, Neuroticism and brain function: A PET
study of personality Incorrect contrast
Haas 2007 Emotional conflict and neuroticism: personality-dependent activation in the amygdala and subgenual anterior cingulate
Incorrect contrast
Herwig 2007 Neural correlates of a 'pessimistic' attitude when
anticipating events of unknown emotional valence Incorrect contrast Table S1 Overview of reasons for excluding certain relevant studies from the meta-analysis
Author Year Title Reason for exclusion Iaria 2008 Neural activity of the anterior insula in emotional
processing depends on the individuals' emotional susceptibility
Incorrect contrast
Jimura 2010 Temporal pole activity during understanding other
persons' mental states correlates with neuroticism trait Incorrect contrast Moriguchi 2009 The human mirror neuron system in a population with
deficient self-awareness: an fMRI study in alexithymia Incorrect contrast Paulus 2003 Increased activation in the right insula during
risk-taking decision making is related to harm avoidance and neuroticism
Incorrect contrast
Schaefer 2012 Striatal response to favorite brands as a function of
neuroticism and extraversion Incorrect contrast
Simmons 2008 Intolerance of uncertainty correlates with insula
activation during affective ambiguity Incorrect contrast Terasawa 2012 Anterior insular cortex mediates bodily sensibility and
social anxiety Incorrect contrast
See section ‘Selection Criteria’ and Figure 1 PRISMA flow diagram for the selection criteria.
Table S1 Continued
2
Contrast Correlation Total nr. of
studies Field of view Nr. of
studies Significance Nr. of studies
Neg>Neu Positive 15 Whole-brain 5 Significant 3
Non-significant 2
ROI 6 Significant 0
Non-significant 2
Both 4
Both 4 Significant 0
Non-significant 0
Both 4
Neg>Neu Negative 14 Whole-brain 5 Significant 4
Non-significant 1
ROI 7 Significant 0
Non-significant 6
Both 1
Both 2 Significant 0
Non-significant 2
Both 0
Pos>Neu Positive 10 Whole-brain 3 Significant 3
Non-significant 0
ROI 5 Significant 0
Non-significant 5
Both 0
Both 2 Significant 0
Non-significant 1
Both 1
Pos>Neu Negative 9 Whole-brain 3 Significant 1
Non-significant 2
ROI 5 Significant 0
Non-significant 4
Both 1
Both 1 Significant 0
Non-significant 0
Both 1
Pos, positive; Neg, negative; Neu, neutral; ROI, region of interest.
Table S2 Overview of the literature findings per contrast 2.8.2 S2 Literature findings per contrast
Study Year ROI Side AAL label Contrast
Brassen 2010 Anterior
cingulate cortex Left Cingulum_
Ant_L 4001 Pos>Neu, Pos corr
2201 Pos>Neu, Pos corr
Pos>Neu, Neg corr
Canli 2004 Anterior
cingulate gyrus Left Cingulum_
Ant_L 4001 Neg>Neu, Pos corr
Ant_R 4002 Neg>Neu, Pos corr
Cremers 2010 Dorsal medial
prefrontal cortex
Left Frontal_Sup_
Medial_L 2601 Neg>Neu, Pos corr
Neg>Neu, Neg corr
Right Frontal_Sup_
Medial_R 2602 Neg>Neu, Pos corr * Neg>Neu, Neg corr
Amygdala Left Amygdala_L
4201 Neg>Neu, Pos corr
Neg>Neu, Neg corr
Right Amygdala_R
4202 Neg>Neu, Pos corr
Neg>Neu, Neg corr
Table S3 Overview of the selected ROIs per study and their significance 2.8.3 S3 Selected ROIs and their significance
2
Study Year ROI Side AAL label Contrast
Anterior
cingulate cortex Left Cingulum_
Ant_L 4001 Neg>Neu, Pos corr
Neg>Neu, Neg corr
Right Cingulum_
Ant_R 4002 Neg>Neu, Pos corr
Neg>Neu, Neg corr
Drabant 2008 Amygdala Left Amygdala_L
4201 Neg>Neu, Pos corr
Neg>Neu, Neg corr
Right Amygdala_R
4202 Neg>Neu, Pos corr
Neg>Neu, Neg corr
Inferior parietal
lobule Right Occipital_
Mid_R 5202 Neg>Neu, Pos corr
Medial_L 2601 Neg>Neu, Pos corr
Neg>Neu, Neg corr
Middle frontal
gyrus Left Frontal_Mid_L
2201 Neg>Neu, Pos corr
Neg>Neu, Neg corr
Right Frontal_Mid_R
2202 Neg>Neu, Pos corr
Neg>Neu, Neg corr
Superior
parietal lobule Left Parietal_Sup_L
6101 Neg>Neu, Pos corr
Angular_L 6221 Table S3 Continued
Study Year ROI Side AAL label Contrast Parietal_Inf_L
6201
Neg>Neu, Neg corr
Haas 2008 Medial
prefrontal cortex
Left Frontal_Sup_
Medial_L 2601 Neg>Neu, Pos corr *
Medial_R 2602 Neg>Neu, Pos corr
Amygdala Left Amygdala_L
4201 Neg>Neu, Pos corr
Right Amygdala_R
4202 Neg>Neu, Pos corr
Harenski 2009 Amygdala Left Amygdala_L
4201 Neg>Neu, Pos corr *
Right Amygdala_R
4202 Neg>Neu, Pos corr
4201 Neg>Neu, Pos corr
4202 Neg>Neu, Pos corr
Hippocam-pus_R 4102 Table S3 Continued
2
Study Year ROI Side AAL label Contrast
ParaHippocam-pal_R 4112
Pos>Neu, Pos corr
Hyde 2011 Ventral
amygdala Left Amygdala_L
4201 Neg>Neu, Neg corr
Neg>Neu, Pos corr
Right Amygdala_R
4202 Neg>Neu, Neg corr
Neg>Neu, Pos corr
Dorsal
amygdala Left Amygdala_L
4201 Neg>Neu, Neg corr
Neg>Neu, Pos corr
Right Amygdala_R
4202 Neg>Neu, Neg corr
Neg>Neu, Pos corr
Jimura 2009 Temporal pole Left Temporal_Pole_
Sup_L 8121 Neg>Neu, Pos corr *
Medial_L 2601 Neg>Neu, Pos corr
Fujiwara 2008 Prefrontal
cortex Left Frontal_Sup_
Medial_L 2601 Neg>Neu, Pos corr *
Study Year ROI Side AAL label Contrast
Medial_R 2602 Neg>Neu, Pos corr
Mobbs 2005 Prefrontal
cortex Right Frontal_Sup_
Medial_R 2602 Pos>Neu, Neg corr * Frontal_Sup_R 2102
Table S3 Continued
2
Study Year ROI Side AAL label Contrast
Frontal_Mid_R
accumbens Right Caudate_L 7001 Pos>Neu, Neg corr * Putamen_L
7011
Amygdala Left Amygdala_L
4201 Pos>Neu, Pos corr
Pos>Neu, Neg corr
Thomas 2011 Amygdala Left Amygdala_L
4201 Neg>Neu, Pos corr
4202 Neg>Neu, Pos corr
Hippocampus Left Hippocampus_L
4101 Neg>Neu, Pos corr
Table S3 Continued
Study Year ROI Side AAL label Contrast
Hippocam-pus_R 4102 Neg>Neu, Pos corr
Parahippocam-pal gyrus Left
ParaHippocam-pal_L 4111 Neg>Neu, Pos corr
ParaHippocam-pal_R 4112 Neg>Neu, Pos corr
Globus pallidus Left Pallidum_L
7021 Neg>Neu, Pos corr
7022 Neg>Neu, Pos corr
Neg>Neu, Neg corr
Table S3 Continued
2
Study Year ROI Side AAL label Contrast
Pos>Neu, Pos corr
Pos>Neu, Neg corr
Thalamus Left Thalamus_L
7101 Neg>Neu, Pos corr
7102 Neg>Neu, Pos corr
Caudate Left Caudate_L 7001 Neg>Neu, Pos
corr
Right Caudate_R 7002 Neg>Neu, Pos corr
Putamen Left Putamen_L
7011 Neg>Neu, Pos corr
Study Year ROI Side AAL label Contrast Pos>Neu, Neg corr
Right Putamen_R
7012 Neg>Neu, Pos corr
Insula Left Insula_L 3001 Neg>Neu, Pos
corr
Right Insula_R 3002 Neg>Neu, Pos corr
Fusiform Left Fusiform_L
5401 Neg>Neu, Pos corr
5402 Neg>Neu, Pos corr
2
Study Year ROI Side AAL label Contrast
Prefrontal cortex (BA9/44/45)
Left Frontal_Sup_
Medial_L 2601 Neg>Neu, Pos corr
Medial_R 2602 Neg>Neu, Pos corr
Left Rectus_L 2701 Neg>Neu, Pos corr
Study Year ROI Side AAL label Contrast Right Rectus_R 2702 Neg>Neu, Pos
corr
Ant_L 4001 Neg>Neu, Pos corr
Ant_R 4002 Neg>Neu, Pos corr
Significant ROI findings are marked with an asterisk (*). AAL, Automated Anatomical Labeling; Corr, correlation; Pos, positive; Neg, negative; Neu, neutral; ROI, region of interest.
Table S3 Continued