Posterior capsule opaciﬁcation - Veva De Groot Dokter in de genees-, heel-, en verloskunde

Goins KM, Ortiz JR, Fulcher SFA, Handa JT, Jaffe GJ, Foulks GN, Cobo LM. Inhibition of proliferat-ing lens epithe-lium with antitransferrin receptor immunotoxin. J Cataract Refract Surg 1994;

20:513-516

Hansen SO, Solomon KD, McKnight GT, Wilbrandt TH, Gwin TD, O’Morchoe DJ, Tetz MR, Apple DJ.

Posterior capsular opaciﬁcation and intra-ocular lens decentration: 1. Comparison of various posterior chamber lens designs implanted in the rabbit model. J Cataract Refract Surg 1988;

14:605-613

Hansen TJ, Tyndall R, Soil DB. Methotrexate-anticollagen conjugate inhibits in vitro lens cell out-growth. Invest Ophthalmol Vis Sci 1987; 28:1206-1209

Hara T, Hara T, Yamada Y. “Equator ring” for maintenance of the completely circular contours of the capsular bag equator after cataract removal. Ophthalmic Surg 1991; 22:358-359

Hartmann C, Wiedemann P, Gothe K, et al. Nachstarprävention durch endo-kapsuläre Daunomycin-applikation. In: Kongreb der Deutschen Gesellschaft für Intraokularlinsen Implantation (Vol. 2, Edn. 4). Edited by Freyler H, Skorpik C, GrasI M (3 Marz 1989, Wien) Vienna, New York, Springer-Verlag 1990; 414-422

Haus CM, Galand AL. Mitomycin against posterior capsular opaciﬁcation: an experimental study in rabbits. Br J Ophthalmol 1996; 80:1087-1091

Hogan MJ, Alvarado JA et Weddell JE. Histology of the human eye. Saunders, Philadelphia, 1971.

Hollick EJ, Spalton DJ, Ursell PG, Pande MV. Biocompatibility of polymethylmediacrylate, silicone and AcrySof intraocular lenses: randomized comparison of the cellular reaction on the anterior lens surface. J Cataract Refract Surg 1998; 24:361-366

Hollick EJ, Spalton DJ, Meacock WR. The effect of capsulorhexis size on posterior capsule opaciﬁca-tion: one-year results of a randomized prospective trial. Am J Ophthalmol 1999; 128:271-279 Hollick EJ, Spalton DJ, Ursell PG. Surface cytologic features on intraocular lenses: can increased

biocompatibility have disadvantages? Arch Ophthalmol 1999; 117:872-878

Holweger RR, Marefat B. Intraocular pressure change after neodymium:YAG capsulotomy. J Cataract Refract Surg 1997; 23:115-121

International Dictionary of Medicine and Biology, Vol 1, New York, NY, Churchill Livingstone 1986 Ionides A, Dowler JG, Hykin PG, Rosen PH, Hamilton AM. Posterior capsule opaciﬁcation follow-ing

diabetic extracapsular cataract extraction. Eye 1994; 8:535-537

Ismail MM, Alió JL, Ruiz Moreno JMR. Prevention of secondary cataract by antimitotic drugs: ex-perimental study. Ophthalmic Res 1996; 28:64-69

Javitt JC, Tielsch JM, Canner JK, Kolb MM, Sommer A, Steinberg EP. National outcomes of cataract extraction. In-creased risk of retinal complications associated with Nd:YAG laser capsulotomy.

The Cataract Patient Outcomes Research Team. Ophthalmol 1992; 99:1487-1497

Jensen AA, Basti S, Greenwald MJ, Mets MB. When may the posterior capsule be preserved in pedi-atric intraocular lens surgery? Ophthalmol 2002; 109:324-327

Kappelhof JP, Vrensen GF, de Jong PT, Pameyer J, Willekens BL. The ring of Soemmerring in man: an ultrastructural study. Graefes Arch Clin Exp Ophthalmol 1987; 225:77-83

Kappelhof JP, Vrensen GFJM. The pathology of after-cataract: a minireview. Acta Ophthalmol Suppl 1992; 205:13-24

Knorz MC, Soltau JB, Seiberth V, Lorger C. Incidence of posterior capsule opaci-ﬁcation after extracapsular cataract extraction in diabetic patients. Metab Pediatr Syst Ophthalmol 1991;

14:57-58

Krishna R, Meisler DM, Lowder CY, Estafanous M, Foster RE. Long-term follow-up of extracapsular cataract extraction and posterior chamber intraocular lens implantation in patients with uveitis.

Ophthalmol 1998; 105:1765-1769

Kruger AJ, Schauersberger J, Abela C, Schild G, Amon M. Two year results: sharp versus rounded optic edges on silicone lenses. J Cataract Refract Surg 2000; 26:566-570

Bretton RH, Swearingen A, Kash RL, Cooley R. Use of a polylysine-saporin con-jugate to prevent posterior capsule opaciﬁcation. J Cataract Refract Surg 1999; 25:921-929

Buehl W, Findl O, Menapace R, Rainer G, Sacu S, Kiss B, Petternel V, Georgopoulos M. Effect of an acrylic intraocular lens with a sharp optic edge on posterior capsule opaciﬁcation. J Cataract Refract Surg 2002; 28:1105-1111

Buehl W, Menapace R, Sacu S, Kriechbaum K, Koeppl C, Wirtitsch M, Georgopoulos M, Findl O. Effect of a silicone intraocular lens with a sharp posterior optic edge on posterior capsule opaciﬁca-tion. J Cataract Refract Surg 2004; 30:1661-1667

Chang DF. Silicone IOL biocompatibility – Not all silicone is the same. J Cataract Refract Surg 2000; 26:1102

Clark DS, Emery JM, Munsell MF. Inhibition of posterior capsule opaciﬁcation with an immunotoxin speciﬁc for lens epithelial cells: 24 months clinical re-sults. J Cataract Refract Surg 1998;

24:1614-1620

Clark DS. Posterior capsule opaciﬁcation. Curr Opin Ophthalmol 2000; 11:56-64

Cortina P, Gomez-Lechon MJ, Navea A, Menezo JL, Terencio MC, Diaz-Llopis M. Diclofenac sodium and cyclo-sporin A inhibit human lens epithelial cell proliferation in culture. Graefes Arch Clin Exp Ophthalmol 1997; 235:180-185

Couderc BC, de Neuville S, Douin-Echinard V, Serres B, Manenti S, Darbon JM, Malecaze F. Retrovi-rus-mediated transfer of a suicide gene into lens epithelial cells in vitro and in an experimental model of posterior capsule opaciﬁcation. Curr Eye Res 1999; 19:472-482

Dana M.R., Chatzistefanou K., Schaumberg D.A., Foster C.S. Posterior capsule opaci-ﬁcation after cataract surgery in patients with uveitis. Ophthalmol. 1997, 104 (9), 1387-1394

Davidson MG, Harned J, Grimes AM, Duncan G, Wormstone IM, McGahan MC. Transferrin in after-cataract and as a survival factor for lens epithelium. Exp Eye Res 1998; 66:207-215

Davis P, Hill P. Inhibition of capsule opaciﬁcation by convex surface posterior three-piece all-PMMA C-loop lenses: a fellow eye and same lens study. Eur J Implant Refract Surg 1989; 2:237-240 Davison JA. Neodymium:YAG laser posterior capsulotomy after implantation of Acrysof intraocular

lenses. J Cataract Refract Surg 2004; 30:1492-1500

Duncan G, Wormstone IM, Liu CS, Marcantonio JM, Davies PD. Thapsigargin-coated intraocular lenses inhibit human lens cell growth. Nat Med 1997; 3:1026-1028

Duncan G. Lens cell growth and posterior capsule opaciﬁcation: in vivo and in vitro observations.

Br J Ophthalmol 1998; 82:1102-1103

Faust KJ. Hydrodissection of soft nuclei. J Am Intraocul Implant Soc 1984; 10:75-77 Fine IH. Cortical cleaving hydrodissection. J Cataract Refract Surg 1992; 18:508-512

Font RL, Brownstein S. A light and electron microscopic study of anterior subcapsular cataracts.

Am J Ophthalmol 1974; 78:972-984

Galand A, Van Cauwenberge F, Moosavi J. Posterior capsulorhexis in adult eyes with intact and clear capsules. J Cataract Refract Surg 1996; 22:458-461

Gayton JL, Apple DJ, Peng Q, Visessook N, Sanders V, Werner L, Pandey SK, Escobar-Gomez M, Hod-dinott DS, Van Der Karr M. Interlenticular opaciﬁcation: clinicopathological correlation of a complication of posterior chamber piggyback intraocular lenses. J Cataract Refract Surg 2000;

26:330-336

Gimbel HV, Neuhann T. Developments, advantages and methods of the continuous circular capsu-lorhexis technique. J Cataract Refract Surg 1990; 16:31-37

Gimbel HV. Hydrodissection and hydrodelineation. Int Ophthalmol Clin 1994; 34:73-90

Gimbel HV. Posterior capsule tears using phacoemulsiﬁcation, prevention and management. Eur J Implant Refract Surg 1990; 2:63-69

Goarnisson S, Hennekes R. Medium term results of HEMA intraocular lenses. Bull Soc belge Oph-thalmol 1999; 272:63-68

Chapter I Posterior capsule opaciﬁcation

Nagata T, Minakata A, Watanabe I. Adhesiveness of AcrySof to a collagen ﬁlm. J Cata-ract Refract Surg 1998; 24:367-370

Newland TJ, McDermott ML, Eliott D, Hazlett LD, Apple DJ, Lambert RJ, Barrett RP. Experimental neodymium:YAG laser dam-age to acrylic poly (methyl methacrylate), and silicone intraocular lens materials. J Cataract Refract Surg 1999; 25:72-76

Nishi 0. Incidence of posterior capsule opaciﬁcation in eyes with and without posterior chamber intraocular lenses. J Cataract Refract Surg 1986; 12:519-522

Nishi 0, Nishi K, Fujiwara T, Shirasawa E. Effects of diclofenac sodium and indomethacin on pro-liferation and collagen synthesis of lens epithelial cells in vitro. J Cataract Refract Surg 1995;

21:461-465

Nishi 0, Nishi K, Yamada Y, Mizumoto Y. Effect of indomethacin-coated posterior chamber intra-ocular lenses on postoperative inﬂammation and posterior cap-sule opaciﬁcation. J Cataract Refract Surg 1995; 21:574-578

Nishi 0, Nishi K, Mano C, Ichihara M, Honda T, Saitoh I. Inhibition of migrating lens epithelial cells by blocking the adhesion molecule integrin: a preliminary report. J Cataract Re-fract Surg 1997; 23:860-865

Nishi 0, Nishi K, Mano C, Ichihara M., Honda T. The inhibition of lens epithelial cell migration by a discontinuous capsular bend created by a circular loop or a capsule-bending ring. Ophthalmic Surg. Lasers. 1998; 29:119-125

Nishi 0, Nishi K, Menapace R. Capsule-bending ring for the prevention of capsular opaciﬁcation: a preliminary report. Ophthalmic Surg Lasers 1998; 29:749-763

Nishi 0, Nishi K. Preventing posterior capsule opaciﬁcation by creating a discontinuous sharp bend in the capsule. J Cataract Refract Surg 1999; 25:521-526

Ohadi C, Moreira H, McDonnell PJ. Posterior capsule opaciﬁcation. Curr Opin Ophthalmol 1991;

2:46-52

Olson L. Anatomy of the human lens. In: Duane’s clinical opthtalmology. Lippincott, Philadelphia 1991; Vol I, Chap 71.

Oner FH, Gunenc U, Ferliel ST. Posterior capsule opaciﬁcation after phaco-emulsiﬁcation: fold-able acrylic versus polymethylmethacrylate intraocular lenses. J Cataract Refract Surg 2000;

26:722-726

Oshika T, Nagata T, Ishii Y. Adhesion of lens capsule to intraocular lenses of polymethylmethac-rylate, silicone and acrylic foldable materials: an experimen-tal study. Br J Ophthalmol 1998;

82:549-553

Pandey SK, Apple DJ, Werner L, Maloof AJ, Milverton EJ. Posterior capsule opaciﬁcation: a review of the aetiopathogenesis, experimental and clinical studies and factors for prevention (review).

Indian J Ophthalmol 2004; 52:99-112

Pearson PA, Solomon KD, Woodford S, et al. Inhibition of posterior capsule opaciﬁcation using sustained delivery 5-ﬂuorouracil (ARVO Abstract No. 638). Invest Ophthalmol Vis Sci 1991;

32:797

Peng Q, Apple DJ, Visessook N, Werner L, Pandey SK, Escobar-Gomez M, Schoderbek R, Guindi A.

Surgical prevention of posterior capsule opaci-ﬁcation: 2. Enhancement of cortical clean up by increased emphasis and focusing on the hydrodissection procedure. J Cataract Refract Surg 2000; 26:188-197

Peng Q, Visessook N, Apple DJ, Pandey SK, Werner L, Escobar-Gomez M, Schoderbek R, Solomon KD, Guindi A. Surgical prevention of posterior capsule opaciﬁcation: part 3: intraocular lens optic barrier effect as a second line of defense. J Cataract Refract Surg 2000; 26:198-213

Phelps Brown N, Bron A. Lens disorders: a clinical manual of cataract diagnosis. Butterworth-Heinemann Ltd 1996

Power WJ, Neylan D, Collum LMT. Daunomycin as an inhibitor of human lens epithelial cell prolifera-tion in culture. J Cataract Refract Surg 1994; 20:287-290

Kuchle M, Amberg A, Martus P, Nguyen NX, Naumann GO. Pseudoexfoliation syndrome and sec-ond-ary cataract. Br J Ophthalmol 1997; 81:862-866

Kurosaka D, Kato K, Nagamoto T. Presence of alpha smooth muscle actin in lens epithelial cells of aphakic rabbit eyes. Br J Ophthalmol 1996; 80:906-910

Kuszak JR, Bertram BA, Macsai MS, Rae JL. Sutures of the crystalline lens: a review. Scan Electron Microsc 1984; 3:1369-1378

Legler UFC, Apple DJ, Assia EI, Bluestein EC, Castaneda VE, Mowbray SL. Inhibition of posterior capsule opaciﬁ-cation: the effect of colchicine in a sustained drug delivery system. J. Cataract Refract. Surg. 1993, 19 (4), 462-470

Linnola RJ. Sandwich theory: bioactive-based explanation for posterior capsule opaci-ﬁcation.

J Cataract Refract Surg 1997; 23:527-535

Linnola RJ, Werner L, Pandey SK, Escobar-Gomez M, Znoiko SL, Apple DJ. Adhesion of ﬁbronectin, vitronectin, laminin and collagen type IV to intraocular lens materials in pseudophakic human autopsy eyes: I. Histological sections. J Cataract Refract Surg 2000; 26:1792-1806

Linnola RJ, Werner L, Pandey SK, Escobar-Gomez M, Znoiko SL, Apple DJ. Adhesion of ﬁbronectin, vitronectin, laminin and collagen type IV to intraocular lens materials in pseudophakic human autopsy eyes: II. Explanted IOLs. J Cataract Refract Surg 2000; 26:1807-1818

Malecaze F, Couderc B, de Neuville S, Serres B, Mallet J, Douin-Echinard V, Manenti S, Revah F, Dar-bon JM. Adenovirus-mediated suicide gene-transduction: feasibility in lens epithelium and in prevention of posterior cap-sule opaciﬁcation in rabbits. Hum Gene Ther 1999; 10:2365-2372 Maloof A, Neilson G, Milverton EJ, Pandey SK. Selective and speciﬁc targeting of lens epithelial

cells during cataract surgery using sealed- capsule irrigation. J Cataract Refract Surg 2003;

29:1566-1568

Marcantonio JM, Vrensen GFJM. Cell biology of posterior capsular opaciﬁcation. Eye 1999; 13:

484-488

Marcantonio JM, Rakic JM, Vrensen GFJM, Duncan G. Lens cell populations studied in human donor capsular bags with implanted intraocular lenses. Invest Opthalmol Vis Sci 2000; 41:1130-1141

Masket S. Truncated edge design, dysphotopsia and inhibition of posterior capsule opaciﬁcation.

J Cataract Refract Surg 2000; 26:145-147

McCulley J.P. Biocompatibility of intraocular lenses (review). Eye Contact Lens. 2003, 29 (3), 155-163

McDonnell PJ, Zarbin MA, Green WQR. Posterior capsule opaciﬁcation in pseudophakic eyes. Oph-thalmol 1983; 90:1548-1553

McDonell PJ, Rowen SL, Glaser BM, Sato M. Posterior capsule opaciﬁcation: an in vitro model. Arch Ophthalmol 1985; 103:1378-1381

McDonell PJ, Krause W, Glaser BM. In vitro inhibition of lens epithelial cell proliferation and migra-tion. Ophthalmic Surg 1988; 19:25-30

Meacock WR, Spalton DJ, Hollick EJ, Boyce JF, Barman S, Sanguinetti G. Double-masked prospective ocular safety study of a lens epithelial cell antibody to prevent posterior capsule opaciﬁcation.

J Cataract Refract Surg 2000; 26:716-721

Meacock WR, Spalton DJ, Stanford MR. Role of cytokines in the pathogenesis of posterior capsule opaciﬁcation. Br J Ophthalmol 2000; 84:332-336

Michael R. Development and repair of cataract induced by ultraviolet radiation. Ophthalmic Res 2000; 32:1-44

Michael R, Vrensen GF, van Marle J, Lofgren S, Soderberg PG. Repair in the rat lens after threshold ultraviolet radiation injury. Invest Ophthalmol Vis Sci 2000; 41:204-212

Nagata T, Watanabe I. Optic sharp edge or convexity: comparison of effects on poste-rior capsular opaciﬁcation. Jpn J Ophthalmol 1996; 40:397-403

Chapter I Posterior capsule opaciﬁcation

Tassignon MJ, De Groot V, Vrensen GFJM. Bag-in the-lens implantation of intraocular lenses.

J Cataract Refract Surg 2002; 28:1182-1188

Tetz MR, Ries MW, Lucas C, Stricker H, Volcker HE. Inhibition of posterior capsule opaciﬁcation by an intraocular-lens-bound sustained drug delivery system: an experimental animal study and literature review. J Cataract Refract Surg 1996; 22:1070-1078

Tetz M, O’Morchoe D, Gwin T, Wilbrandt TH, Solomon KD, Hansen SO, Apple DJ. Posterior capsular opaciﬁcation and intraocular lens decentration: II. Experimental ﬁndings on a prototype circu-lar intraocucircu-lar lens design. J Cataract Refract Surg 1988; 14:614-623

Tobari I, Iwaki Y, Miyake K. Effect of tranilast eye drops in preventing posterior capsule opaciﬁca-tion: preliminary report. J Cataract Refract Surg 1999; 25:1394-1399

Tognetto D, Toto L, Ballone E, Ravalico G. Biocompatibility of hydrophilic intraocular lenses.

J Cataract Refract Surg 2002; 28:644-651

Van Cauwenberge F, Rakic JM, Galand A. Complicated posterior capsulorhexis: etiology, manage-ment and outcome. Br J Ophthalmol 1997; 81:195-198

Van Tenten Y, De Wolf A, Willekens B, Vrensen GF, Tassignon MJ. Temperature threshold for cell death of lens epithelial cells in a human capsular bag model. Exp Eye Res 1999; 69:569-574 Van Tenten Y, De Groot V, Wuyts FL, Tassignon MJ. Quantitative measurement of the PCCC area in

the postoperative period. Br J Ophthalmol 2000; 84:1117-1120

Van Tenten Y, Schuitmaker HJ, De Wolf A, Willekens B, Vrensen GFJM, Tassignon MJ. The effect of photodynamic therapy with bacteriochlorin a on lens epithelial cells in a capsular bag model.

Exp Eye Res 2001; 72:41-48

Van Tenten Y, Schuitmaker HJ, De Groot V, Willekens B, Vrensen GF, Tassignon MJ. A preliminary study on the prevention of posterior capsule opaciﬁcation by photodynamic therapy with bac-teriochlorin A in rabbits. Ophthalmic Res 2002; 34:113-118

Vasavada AR, Trivedi RH, Nath VC. Visual axis opaciﬁcation after AcrySof intraocular lens implanta-tion in children. J Cataract Refract Surg 2004; 30:1073-1081

Vrensen GFJM, Graw J, De Wolf A. Nuclear breakdown during terminal differentiation of primary lens ﬁbres in mice: a transmission electron microscopic study. Exp Eye Res 1991; 52:647-659 Werner L, Apple DJ, Pandey SK. Postoperative proliferation of anterior and equatorial lens epithelial

cells. In: Buratto L, Osher RH, Masket S (eds). Cataract surgery in com-plicated cases. Thorofare NJ, Slack Inc 2000; 399-417

Werner L, Pandey SK, Escobar-Gomez M, Visessook N, Peng Q, Apple DJ. Anterior capsule opaciﬁca-tion: a histopathological study comparing different IOL styles. Ophthalmol 2000; 107:463-471

Werner L., Shugar J.K., Apple D.J., Pandey S.K., Escobar-Gomez M., Visessook N., Evans B.B. Opaci-ﬁcation of piggyback IOLs associated with an amorphous material attached to the interlenticu-lar surfaces. J. Cataract Refract. Surg. 2000; 26:1612-1619

Wormstone I. Posterior capsule opaciﬁcation. Exp Eye Res 2002: 74; 337-347

Wormstone IM, Liu CS, Rakic JM, Marcantonio JM, Vrensen GF, Duncan G. Human lens epithelial cell proliferation in a protein-free medium. Invest Ophthalmol Vis Sci 1997; 38:396-404

Yamada K, Nagamoto T, Yozawa H, Kato K, Kurosaka D, Miyajima HB, Kimura C. Effect of intraocu-lar lens design on posterior capsule opaciﬁcation after continuous curvilinear capsulorhexis.

J Cataract Refract Surg 1995; 21:697-700

Yamada Y, Kojima M, Vrensen GF, Takahashi N, Sasaki K. Acute ultraviolet B induced lens epithe-lial cell photo-damage and its repair process (Japanese). Nippon Ganka Gakkai Zasshi 2001;

105:102-110

Zaczek A, Zetterstrom C. Posterior capsule opaciﬁcation after phacoemulsiﬁcation in patients with diabetes mellitus. J Cataract Refract Surg 1999; 25:233-237

Rakic JM, Galand A, Vrensen GFJM. Separation of ﬁbers from the capsule enhances mitotic activity of human lens epithelium. Exp Eye Res 1997; 64:67-72

Rakic JM, Galand A, Vrensen GF. Lens epithelial cell proliferation in human posterior capsule opaci-ﬁcation specimens. Exp Eye Res 2000; 71:489-494

Ram J, Apple DJ, Peng Q, Visessook N, Auffarth GU, Schoderbek RJ Jr, Ready EL. Update on ﬁxation of rigid and foldable posterior chamber intraocular lenses: I. Elimination of ﬁxation-induced decentration to achieve precise optical correction and visual rehabilitation. Ophthalmol 1999;

106:883-890

Ram J, Apple DJ, Peng Q, Visessook N, Auffarth GU, Schoderbek RJ Jr, Ready EL. Update on fixation of rigid and foldable posterior chamber intraocular lenses: II. Choosing the correct haptic fixa-tion and intraocular lens design to help eradicate posterior capsule opacificafixa-tion. Ophthalmol 1999; 106:891-900

Ram J, Pandey SK, Apple DJ, Werner L, Brar GS, Singh R, Chaudhary KP, Gupta A. Effect of in-the-bag intraocular lens ﬁxation on the prevention of posterior capsule opaciﬁcation. J Cataract Refract Surg 2001; 27:1039-1046

Ram J, Brar GS, Kaushik S, Gupta A, Gupta A. Role of posterior capsulotomy with vitrectomy and intraocular lens design and material in reducing posterior capsule opaciﬁcation after pediatric cataract surgery. J Cataract Refract Surg 2003; 29:1579-1584

Ravalico G., Tognetto D., Palomba M., Busatto P., Baccara F. Capsulorhexis size and posterior cap-sule opaciﬁcation. J. Cataract Refract. Surg. 1996; 22:98-103

Ruiz JM, Medrano M, Alio JL. Inhibition of posterior capsule opaciﬁcation by 5-ﬂuorouracil in rab-bits. Ophthalmic Res 1990; 22:201-208

Ruoslahti E. Stretching is good for a cell. Science 1997; 276:1345-1346

Saika S, Miyamoto T, Okada Y, Yamanaka O, Ohnishi Y, Ooshima A. Transforming growth factor-beta isoform proteins in cell and matrix deposits on intraocular lenses. J Cataract Refract Surg 2000;

26:709-715

Saxby L, Rosen E, Boulton M. Lens epithelial cell proliferation, migration and metaplasia following capsulorhexis. Br J Ophthalmol 1998; 82:945-952

Schaumberg DA, Dana MR, Christen WG, Glynn RJ. A systematic overview of the incidence of poste-rior capsule opaciﬁcation. Ophthalmol 1998; 105:1213-1221

Schmidbauer JM, Vargas LG, Peng Q, Escobar-Gomez M, Werner L, Arthur SN, Apple DJ. Posterior capsular opaciﬁcation. Int Ophthalmol Clin 2001; 41:109-131

Schmidbauer JM, Escobar-Gomez M, Apple DJ, Peng Q, Arthur SN, Vargas LG. Effect of haptic an-gulation on posterior capsule opaciﬁcation in modern foldable lenses with a square, truncated optic edge. J Cataract Refract Surg 2002; 28:1252-1255

Sharma N, Pushker N, Dada T, Vajpayee RB, Dada VK. Complications of pediatric cataract surgery and intraocular lens implantation. J Cataract Refract Surg 1999; 25:1585-1588

Spalton DJ. Posterior capsule opaciﬁcation after cataract surgery. Eye 1999; 13:489-492 Sterling S, Wood T. Effect of intraocular lens convexity on posterior capsule opaciﬁ-cation. J

Cata-ract RefCata-ract Surg 1986; 12:655-657

Sugita M, Kato S, Sugita G, Oshika T. Migration of lens epithelial cells through haptic root of single-piece acrylic-foldable intraocular lens. Am J Opththalmol 2004; 137:377-379

Sundelin K, Sjostrand J. Posterior capsule opaciﬁcation 5 years after extracapsular cataract extrac-tion. J Cataract Refract Surg 1999; 25:246-250

Tassignon MJ, De Groot V, Smets RME, Tawab B, Vervecken F. Secondary closure of posterior continu-ous circular capsulotomy (capsulorhexis). J Cataract Refract Surg 1996; 22:1200-1205 Tassignon MJ, De Groot V, Vervecken F, Van Tenten Y. Secondary closure of posterior

continu-ous curvilinear capsulorhexis in normal eyes and eyes at risk for postoperative inﬂammation.

J Cataract Refract Surg 1998; 24:1333-1338

From the literature it is apparent that, although a multitude of non-surgical ap-proaches have been tested in the last few years, only surgical options are left for preventing PCO. Within this frame, we tested three different surgical approaches, which have been the subject of nine studies in this thesis.

1. First study: IOLs with circular haptics

In the ﬁ rst study we evaluated the advantages of IOLs with circular haptics. IOLs usually have J- or C-loop haptics, which are known to cause folds in the posterior capsule, especially those IOLs with a large total diameter implanted in eyes with a small capsular bag. This problem was found to be less pronounced in IOLs with circular haptics as they are more likely to equally stretch the posterior capsule, allow-ing less LECs to grow because of a better contact between the IOL and the posterior capsule.

In the set-up of this study, we compared IOLs with two different designs of circular haptics: one with a closed loop haptics (n = 335) and one with open loops (n = 103).

We looked at the IOL centration, the presence of folds in the posterior capsule and the PCO rate.

2. Second study: posterior continuous circular capsulorhexis

In the second study an innovative surgical technique is evaluated. Based on the hypothesis that as long as the posterior capsule remains in place there will always be some LECs escaping from the equatorial region and migrating to the posterior capsule that will cause PCO. It was therefore assumed that removing the central part of the posterior capsule would be a drastic way of preventing PCO. To do this, the central part of the posterior capsule is taken out during cataract surgery by a continuous circular capsulorhexis. In analogy with the well-known similar procedure for the anterior capsule (ACCC), this operation is referred to as posterior continuous circular capsulorhexis or PCCC. The ﬁ rst patients treated this way in our center and

In document Veva De Groot Dokter in de genees-, heel-, en verloskunde (pagina 21-25)