LIPOSOME-BASED SYNTHETIC LONG PEPTIDE VACCINES FOR

T cells recognize small protein fragments (peptide) from extracellular or intracellular proteins and T cells can either provide help in the induction of an immune response or can

Here, we report that vaccination with immunogenic OVA8 peptide in IFA also results in the activation of effector CD8 + T-cells which eventually ceased to expand or to kill target

Our cumulative data indicate that the tolerance induced by this peptide in IFA vaccine results from prolonged systemic presentation of antigen in the absence of

The three most potent adjuvants (CpG, MPL and agonistic antibody FGK) were tested for their capacity to enhance the in vivo cytolytic activity of vaccine-induced HPV16 E7-specific

Therefore to evaluate the relevance of TLR expression for the enhanced uptake, bone-marrow dendritic cells BMDCs purified from wild-type WT, TLR2-/-, and TLR9-/- mice were

Similarly, it has been shown that the vaccination induced anti-TC-1 tumor response depends on CD4 + T cell help (22). S2) followed by TC-1 inoculation. As expected, depletion of CD4

These two factors – the predominant local presentation of peptides and the provision of CD4 + T-cell help (53,75)- which are lacking in most of the peptide vaccines used in

Wanneer een peptide van 30 aminozuren lang wordt gebruikt voor vaccinatie - waar dezelfde sequentie van 8-10 aminozuren in zit - blijkt de CD8+ T cel respons veel sterker te zijn