University of Groningen
Towards prevention of AF progression
Hobbelt, Anne
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Publication date: 2019
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Hobbelt, A. (2019). Towards prevention of AF progression. Rijksuniversiteit Groningen.
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Towards prevention of AF
progression
Financial support for the publication of this thesis by the following companies/ institutes is gratefully acknowledged:
University of Groningen, Groningen University for Drug Exploration (GUIDE) The Dutch Heart Foundation
The research described in this thesis was supported by grants of the Dutch Heart Founda-tion (NHS2010B233, NHS2008B035, CVON 2014-09)
ISBN: 978-94-6361-231-9 © Copyright 2018 A.H. Hobbelt
All rights are reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means (electronic, mechanically, photocopy-ing, recording or otherwise), without the permission of the author, and when appropriate the publisher holding the copyrights of the published articles.
Towards prevention of AF progression Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 24 april 2019 om 14.30 uur door
Anne Henrieke Hobbelt
geboren op 25 juni 1987 te Zwolle 3
Towards prevention of AF
progression
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 24 april 2019 om 14.30 uur
door
Anne Henrieke Hobbelt
geboren op 25 juni 1987Promotores
Prof. dr. I.C. van Gelder Prof. dr. M. Rienstra Prof. dr. H.J.G.M. Crijns
Beoordelingscommissie
Prof. dr. A.A. Voors Prof. dr. M.P. van den Berg Prof. dr. F.H. Rutten
Paranimfen
Lotte Gerjanne Hobbelt Mariëlle Kloosterman
Table of ConTenTs
Chapter 1: Introduction 9
Part I – New insights in the pathophysiologic mechanisms of atrial fibrillation Chapter 2: Prethrombotic state in young very-low-risk atrial fibrillation
patients
21 Published in Journal of the American College of Cardiology
Part II – Predictors of different atrial fibrillation patterns
Chapter 3: Clinical, biomarker, and genetic predictors of specific types of atrial fibrillation in a community-based cohort: data of the PREVEND study.
27
Published in Europace
Chapter 4: Progression of atrial fibrillation in a well-characterized low-risk AF population
43 In preparation
Part III – Clinical implications and future treatment strategies
Chapter 5: Targeted therapy of underlying conditions improves sinus rhythm maintenance in patients with persistent AF - results of the RACE 3 trial
61
Published in European Heart Journal
Chapter 6: Editorial: The RACE-3 is on: double-locking sinus rhythm by upstream and downstream therapy
81 Chapter 7: Tailored treatment strategies – a new approach for modern
management of atrial fibrillation
91 Published in Journal of Internal Medicine
Chapter 8: Discussion and future perspectives 109
Appendices: Nederlandse samenvatting 133
Dankwoord 139
Biography 143
