University of Groningen Optimizing levofloxacin dose in the treatment of multidrug-resistant tuberculosis Ghimire, Samiksha

In this thesis we develop a demand-driven and centralized management system that incorporates all planning related activities, called a planning cycle, which aims to align

Publication of this thesis was financially supported by University of Groningen, Univer- sity Medical Center Groningen, Graduate School of Medical Sciences, Eric Bleumink Fund,

Multidrug-resistant tuberculosis treatment outcomes in relation to treatment and initial versus acquired second-line drug resistance. Management of patients

Ultimately, 37 articles were included describing in vitro susceptibility testing of levofloxacin against MDR-TB strains, and clinical studies on pharmacokinetic monitoring

Al- though 86 % of patients with drug susceptible TB are cured with estab- lished first line drugs, treatment is often longer than six months due to slow response, compliance

Treatment success rate is a potentially biased outcome parameter; our primary efficacy end point to estimate the usefulness of LFX was time to sputum culture conversion within

The last study [33] developed and validated a liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method for the analysis of

Therefore, membrane filtration was found to be suitable for sterilization of saliva samples, before analyzing for therapeutic drug monitoring purposes (7). However, it is likely that

In this prospective pharmacokinetic study (May 2016 to October 2017; ERB approval no. 115/2016), we aimed to evaluate the factors associated with time to sputum culture conversion

Saliva may be a useful alternative matrix for monitoring levofloxacin concentrations in multi-drug resistant TB patients. The objectives of this study were: a) to evaluate

Achieving optimal target exposure was positively associated with treatment success in MDR-TB patients based on observational studies.. In a hollow fiber model of TB,

Through our findings, we have shown that currently used levofloxacin dose in MDR-TB patients is inadequate and how sub-optimal drug concentrations in combination with higher MICs

De resultaten van de gevonden studies lieten zien dat 80% van de volwassen MDR-TB patiënten met een hoge minimaal remmende concentratie (MIC, maat voor de gevoeligheid van

Dear Gokarna Sir, Thank you for your support during the early phases of clinical study set-up in Nepal.. You went through great

Linezolid-based regimens for mul- tidrug-resistant tuberculosis (TB): a systematic review to establish or revise the current recommended dose for

Optimizing levofloxacin dose in the treatment of multidrug-resistant tuberculosis Ghimire, Samiksha.. IMPORTANT NOTE: You are advised to consult the publisher's version

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, the

Although the developed tools could aid care providers, the techniques; knowledge and devices required for these tools are often not widely available in high endemic areas, as

In May 2014, he moved to the Netherlands /Groningen to pursue a PhD project at the Department of Clinical Pharmacology, University Medical Center Groningen. He finished working on

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands..

In 2015 he started working at the University Medical Center Groningen (UMCG) at the Department of Clinical Pharmacy and Pharmacology as a project pharmacist, under supervision of

In this study we examined whether 4 to 12-year-old children with DCD differ from typi- cally developing (TD) children regarding their participation involvement (enjoyment) and

Dit proefschrift benadrukt dat bewegen er toe doet voor kinderen met DCD: de motorische problemen die kinderen met DCD ervaren, kunnen een aanzienlijke impact hebben op fitheid,