University of Groningen
Neurobiological determinants of depressive-like symptoms in rodents
Bove, Maria
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Publication date:
2018
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Citation for published version (APA):
Bove, M. (2018). Neurobiological determinants of depressive-like symptoms in rodents: A multifactorial
approach. University of Groningen.
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PROPOSITIONS
Neurobiological determinants of depressive-like symptoms
in rodents
Maria Bove
1. Depression is one of the most common psychiatric diseases; indeed the prevalence of depressive symptoms has reached epidemic proportions during the last few decades.
2. Depressive-like symptoms commonly occur in several neuropsychiatric disorders, such as schizophrenia, bipolar disorders, Alzheimer’s diseases, anxiety disorders, autism spectrum disorders and stress-related diseases. 3. Diets, genetics and lifestyle contribute to the onset and progression of
mental illnesses.
4. During the last decades, diagnosis in psychiatry only focused on subjective symptoms and observable signs. Although symptoms are an important starting point, genetics and neurobiology underlying these symptoms need to be investigated.
5. Animal models can be really helpful to longitudinally study behavioural alterations resembling human symptoms and ultimately unravel the etiopathogenesis.
6. An important depressive-like symptom affecting the social sphere is social withdrawal. Social withdrawal, defined as lack of desire to have social contact, is an early symptom of a wide variety of neuropsychiatric diseases, including schizophrenia, autism spectrum disorders and major depression. 7. “Science is simply the word we use to describe a method of organizing
curiosity.” Tim Minchin
8. “Science never solves a problem without creating ten more.” George Bernard Shaw