• No results found

University of Groningen Neurobiological determinants of depressive-like symptoms in rodents Bove, Maria

N/A
N/A
Protected

Academic year: 2021

Share "University of Groningen Neurobiological determinants of depressive-like symptoms in rodents Bove, Maria"

Copied!
2
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

University of Groningen

Neurobiological determinants of depressive-like symptoms in rodents

Bove, Maria

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Bove, M. (2018). Neurobiological determinants of depressive-like symptoms in rodents: A multifactorial

approach. University of Groningen.

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

(2)

PROPOSITIONS

Neurobiological determinants of depressive-like symptoms

in rodents

Maria Bove

1. Depression is one of the most common psychiatric diseases; indeed the prevalence of depressive symptoms has reached epidemic proportions during the last few decades.

2. Depressive-like symptoms commonly occur in several neuropsychiatric disorders, such as schizophrenia, bipolar disorders, Alzheimer’s diseases, anxiety disorders, autism spectrum disorders and stress-related diseases. 3. Diets, genetics and lifestyle contribute to the onset and progression of

mental illnesses.

4. During the last decades, diagnosis in psychiatry only focused on subjective symptoms and observable signs. Although symptoms are an important starting point, genetics and neurobiology underlying these symptoms need to be investigated.

5. Animal models can be really helpful to longitudinally study behavioural alterations resembling human symptoms and ultimately unravel the etiopathogenesis.

6. An important depressive-like symptom affecting the social sphere is social withdrawal. Social withdrawal, defined as lack of desire to have social contact, is an early symptom of a wide variety of neuropsychiatric diseases, including schizophrenia, autism spectrum disorders and major depression. 7. “Science is simply the word we use to describe a method of organizing

curiosity.” Tim Minchin

8. “Science never solves a problem without creating ten more.” George Bernard Shaw

Referenties

GERELATEERDE DOCUMENTEN

More specifically, by using different animal models and behavioural paradigms resembling human depressive-like symptoms, we evaluated the underlying neurobiological

We also analyzed dopamine content in PFC of female rats exposed during their entire life to n-3 PUFA enriched or control diets 7 days after Aβ icv injection;

Moreover, n-3 PUFA deficient females showed a significant increase in glutamate content compared to females fed with n-3 PUFA enriched diet in both amygdala (Figure 5C, One-way

Our results showed that there were no differences in time spent performing alone inactivity per day between the two strains (Fig. 3A, Two-way ANOVA RM followed by Bonferroni’s,

Our results showed that no genotype differences were detected in GABA content in standard- housed mice (Fig. 4A, One-way ANOVA followed by Bonferroni, n.s.), while

In conclusion, the decrease in GABA and the corresponding increase in glutamate in prefrontal cortex and amygdala might be responsible of the decrease in social

Omega-3 polyunsaturated fatty acid (PUFA) status in major depressive disorder with comorbid anxiety disorders.. Chronic stress impairs GABAergic control of

Furthermore, in order to investigate neurobiology behind sociability and social withdrawal, in chapter 4, we analyzed GABA and glutamate content in prefrontal