University of Groningen
Protein delivery from polymeric matrices
Teekamp, Naomi
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Teekamp, N. (2018). Protein delivery from polymeric matrices: From pre-formulation stabilization studies to site-specific delivery. Rijksuniversiteit Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
PROTEIN DELIVERY
from
POLYMERIC MATRICES
From pre-formulation stabilization studies
to site-specific delivery
Naomi Teekamp
PROTEIN DELIVERY
from
POLYMERIC MATRICES
From pre-formulation stabilization studies
to site-specific delivery
Colophon
Cover artwork: Dirk Duin
Layout & cover design: Design Your Thesis, www.designyourthesis.com Printing: Ridderprint BV, www.ridderprint.nl
ISBN: 978-94-6299-895-7 ISBN (digital): 978-94-6299-920-6
The research presented in this thesis was carried out at the Department of Pharmaceutical Technology and Biopharmacy of the University of Groningen. Financial support for printing the thesis was received from InnoCore Technologies, the University Library and the Graduate School of Science and Enigineering of the University of Groningen.
© Copyright Naomi Teekamp, 2018.
All rights reserved. No part of this publication may be reproduced , stored on a retreival system, or transmitted in any form or by any means, without permission of the author.
Colophon
Cover artwork: Dirk Duin
Layout & cover design: Design Your Thesis, www.designyourthesis.com Printing: Ridderprint BV, www.ridderprint.nl
ISBN: 978-94-6299-895-7 ISBN (digital): 978-94-6299-920-6
The research presented in this thesis was carried out at the Department of Pharmaceutical Technology and Biopharmacy of the University of Groningen. Financial support for printing the thesis was received from InnoCore Technologies, the University Library and the Graduate School of Science and Enigineering of the University of Groningen.
© Copyright Naomi Teekamp, 2018.
All rights reserved. No part of this publication may be reproduced , stored on a retreival system, or transmitted in any form or by any means, without permission of the author.
Protein delivery from
polymeric matrices
From pre-formulation stabilization studies to site-specific delivery
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op vrijdag 20 april 2018 om 14.30 uur
door
Naomi Teekamp
geboren op 17 januari 1987 te Zevenaar
Protein delivery from
polymeric matrices
From pre-formulation stabilization studies to site-specific delivery
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op vrijdag 20 april 2018 om 14.30 uur
door
Naomi Teekamp
geboren op 17 januari 1987 te Zevenaar
Promotores Prof. dr. P. Olinga Prof. dr. H.W. Frijlink Copromotor Dr. W.L.J. Hinrichs Beoordelingscommissie Prof. dr. C. Foged Prof. dr. M.J.T.H. Goumans Prof. dr. G. Molema Promotores Prof. dr. P. Olinga Prof. dr. H.W. Frijlink Copromotor Dr. W.L.J. Hinrichs Beoordelingscommissie Prof. dr. C. Foged Prof. dr. M.J.T.H. Goumans Prof. dr. G. Molema
CONTENTS
7
15
Chapter 1. Introduction and scope of
this thesis Chapter 2. Production methods and stabilization strategies for polymer-based nanoparticles and microparticles for parenteral delivery of peptides and
proteins
57
79
Chapter 3. Addition of Pullulan to Trehalose Glasses Improves the Stability
of β-Galactosidase at High Moisture Conditions
Chapter 4. Protein Stability during Hot Melt Extrusion: The Effect of Extrusion Temperature, Sugar Glass Pre-stabilization and Hydrophilicity of
Polymers
101
131
Chapter 5. Polymeric Microspheres for the Sustained Release of a Protein-based Drug Carrier Targeting the
PDGFβ-Receptor in the Fibrotic Kidney
Chapter 6. Pharmacokinetics and Pharmacodynamics of a Sustained Release Formulation of PDGFβ-Receptor Directed Proteins to Target
the Fibrotic Liver
159
181
Chapter 7. General Discussion and
Future Directions Curriculum Vitae, List of Publications, Chapter 8. Summary, Samenvatting, Dankwoord
CONTENTS
7
15
Chapter 1. Introduction and scope of
this thesis Chapter 2. Production methods and stabilization strategies for polymer-based nanoparticles and microparticles
for parenteral delivery of peptides and proteins
57
79
Chapter 3. Addition of Pullulan to Trehalose Glasses Improves the Stability
of β-Galactosidase at High Moisture Conditions
Chapter 4. Protein Stability during Hot Melt Extrusion: The Effect of Extrusion Temperature, Sugar Glass Pre-stabilization and Hydrophilicity of
Polymers
101
131
Chapter 5. Polymeric Microspheres for the Sustained Release of a Protein-based Drug Carrier Targeting the
PDGFβ-Receptor in the Fibrotic Kidney
Chapter 6. Pharmacokinetics and Pharmacodynamics of a Sustained Release Formulation of PDGFβ-Receptor Directed Proteins to Target
the Fibrotic Liver
159
181
Chapter 7. General Discussion and
Future Directions Curriculum Vitae, List of Publications, Chapter 8. Summary, Samenvatting, Dankwoord
