University of Groningen
Designing artificial enzymes with unnatural amino acids
Drienovská, Ivana
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2017
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Drienovská, I. (2017). Designing artificial enzymes with unnatural amino acids. University of Groningen.
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STELLINGEN Behorende bij het proefschrift
Designing artificial enzymes with unnatural amino acids
Ivana Drienovská
1. The journey of the manuscript from first draft to final published version is astonishing; reading my own papers is often a surprise to me.
2. It is a great debate whether being able to perform a certain task ( i.e. do organic synthesis) allows you to call yourself a master of it (organic chemist) or even justifies you to ask for an endorsement at LinkedIn.
3. Combining beneficial mutations doesn’t always lead to a beneficial outcome. (Chapter 2 and Chapter 6) Arch Biochem Biophys. 1992; 294, 327-340.
4. The laborious preparation of metal-binding unnatural amino acids slows the advance of the field.
5. Efficiency and saturation kinetics are important characteristics of enzymes. However, they shouldn’t be used as a determination whether we can call catalyst an enzyme.
6. Being able to do all different parts of your research is a great opportunity, however creates a great level of frustration about the progress of your project (Chapter 3)
7. "We did this differently in my old lab" is not a valid excuse (not) to do anything different.
