University of Groningen
Blends of trehalose and pullulan to stabilize biopharmaceuticals in alternative dosage forms: orodispersible films and dissolving microneedles
Tian, Yu
DOI:
10.33612/diss.135502200
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Tian, Y. (2020). Blends of trehalose and pullulan to stabilize biopharmaceuticals in alternative dosage forms: orodispersible films and dissolving microneedles. University of Groningen.
https://doi.org/10.33612/diss.135502200
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PROPOSITIONS
Belonging to the thesis
Blends of trehalose and pullulan to stabilize
biopharmaceuticals in alternative dosage forms:
orodispersible films and dissolving microneedles
Yu Tian
1. A broad application of biopharmaceuticals is hampered by two main challenges: improvement of their stability and the development of a convenient route of administration. (this thesis)
2. At certain ratios, blends of trehalose and pullulan stabilizes β-galactosidase better than either trehalose or pullulan alone when exposed to high relative humidity conditions (this thesis).
3. Orodispersible films based on trehalose/pullulan blends could be an attractive alternative dosage form for the delivery of biopharmaceuticals in the oral cavity (this thesis).
4. The ease of transportability, handling and administration make oromucosal films a suitable dosage form for patients suffering from dysphagia, young children and elderly people (this thesis).
5. Trehalose/pullulan based dissolving microneedles do not only exhibit excellent mechanical properties, but also provide excellent stability of incorporated whole inactivated influenza virus vaccine (this thesis).
6. Everything will be okay in the end. If it's not okay, it's not the end (John Lennon).
7. Do not try to be the best, but never forget to try your best (Debasish Mridha). 8. Keep your face to the sunshine and you cannot see the shadows (Helen
