University of Groningen
In silico patient Wegrzyn, Agnieszka
DOI:
10.33612/diss.126805978
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Wegrzyn, A. (2020). In silico patient: systems medicine approach to inborn errors of metabolism. University of Groningen. https://doi.org/10.33612/diss.126805978
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Propositions belonging to the thesis
In silico patient
Systems medicine approach to inborn errors of metabolism
Agnieszka B. Węgrzyn
1. Adequate inclusion of cofactors in constraint-based modelling contributes to higher precision in computational predictions.
This dissertation (chapter 2)
2. Di- and tripeptides are interesting candidate biomarkers for Refsum Disease that require validation.
This dissertation (chapter 3)
3. In PKU, both serotonin and dopamine are strongly negatively controlled by blood phenylalanine via the negative inhibition of tyrosine and tryptophan hydroxylases by phenylalanine.
This dissertation (chapter 4)
4. To properly validate predictions, we should know not only the true positive values but also the true negative values. This step would require scientists to share their negative results more openly to populate the yet non-existing ‘True Negative Database’.
This dissertation (chapter 5)
5. In the future, generic models, aided by integrative network analysis and multi-omics data, will provide invaluable insight into complex metabolic networks and provide a platform to introduce patient-specific data-driven diagnosis and therapies.
This dissertation (chapter 5)
6. “(…) the philosopher might have marvelled that such a four-square people could give the world so many successful magical practitioners, being quite unaware that only those with their feet on rock can build castles in the air.”
Terry Pratchett “Carpe Jugulum”
7. "I may not have gone where I intended to go, but I think I have ended up where I needed to be."
Douglas Adams “The Long Dark Tea-Time of the Soul”
8. “Nothing in life is to be feared; it is only to be understood. Now is the time to understand more, so that we may fear less.”
