University of Groningen
Novel views on endotyping asthma, its remission, and COPD
Carpaij, Orestes
DOI:
10.33612/diss.136744640
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Publication date:
2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Carpaij, O. (2020). Novel views on endotyping asthma, its remission, and COPD. University of Groningen.
https://doi.org/10.33612/diss.136744640
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Novel views on endotyping asthma,
its remission, and COPD
Novel views on endotyping asthma, its remission, and COPD
ISBN/EAN
978-94-6375-586-3
Cover design by
Christina van Lokven
Layout and design by
Marilou Maes, persoonlijkproefschrift.nl
Printing
Ridderprint | www.ridderprint.nl
Copyright © 2020 Orestes Carpaij
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in
any way or by any means without the prior permission of the author, or when applicable,
of the publishers of the scientific papers.
Printing of this thesis was financially supported by the University of Groningen, University
Medical Center Groningen, Department of Pulmonary Diseases UMCG, Stichting Astma Bestrijding,
Longfonds, Chipsoft, Chiesi, and PExA.
Novel views on endotyping asthma,
its remission, and COPD
-
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 9 november 2020 om 16.15 uur
door
Orestes Alexander Carpaij
geboren op 22 november 1988 te Nijmegen
Table of content
Chapter 1 General introduction 7
Chapter 2 The pathophysiology of asthma remission 29
Chapter 3 Childhood factors associated with complete and clinical asthma remission at 25 and 49 years
77
Chapter 4 Assessing small airways dysfunction in asthma, asthma remission, and healthy controls using Particles in Exhaled Air (PExA)
91
Chapter 5 Small airways disease and airway inflammation in asthma remission 101
Chapter 6 Applying the CAMP trial asthma remission prediction model to the Dutch asthma remission studies
111
Chapter 7 The asthma-obesity relationship: underlying mechanisms and treatment implications
117
Chapter 8 A cellular census of human lungs identifies novel cell states in health and in asthma
137
Chapter 9 Optical coherence tomography intensity correlates with extracellular matrix components in the airway wall
175
Chapter 10 Serum periostin does not reflect type 2-driven inflammation in COPD 185
Chapter 11 Bronchial gene expression clustering in COPD identifies a subgroup with higher level of bronchial T-cells and accelerated lung function decline
199
Chapter 12 Summary 225
Chapter 13 Discussion and future perspectives 233
Chapter 14 Nederlandse samenvatting 255
Curriculum Vitae 269
Dankwoord 270
Promotor
Prof. dr. H.A.M. Kerstjens
Copromotores
Dr. M. van den Berge Dr. M.C. Nawijn
Beoordelingscommissie
Prof. dr. I. Pavord Prof. dr. P.J. Sterk Prof. dr. R. Gosens
