University of Groningen Adherence to antihypertensive or antihyperlipidemic co-medications in diabetes: patterns, predictors, and intervention Alfian, Sofa

University of Groningen

Adherence to antihypertensive or antihyperlipidemic co-medications in diabetes: patterns,

predictors, and intervention

Alfian, Sofa

DOI:

10.33612/diss.135922731

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Publication date:

2020

Link to publication in University of Groningen/UMCG research database

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Alfian, S. (2020). Adherence to antihypertensive or antihyperlipidemic co-medications in diabetes: patterns,

predictors, and intervention. University of Groningen. https://doi.org/10.33612/diss.135922731

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Adherence to antihypertensive or

antihyperlipidemic co-medications in

diabetes: patterns, predictors, and

intervention

Adherence to antihypertensive or antihyperlipidemic co-medications in diabetes: patterns, predictors, and intervention

ISBN: 978-94-6416-076-5 (printed book) ISBN: 978-94-6416-141-0 (electronic book) Author: Sofa Dewi Alfian

Cover: Yudi Nugraha

Lay out: Ridderprint BV | www.ridderprint.nl Printing: Ridderprint BV | www.ridderprint.nl

This thesis was conducted within the Groningen University Institute for Drug Exploration (GUIDE). Financial support for the printing of this thesis was kindly provided by the Graduate School of Sciences, University of Groningen, the Netherlands.

Sofa Dewi Alfian received a Ph.D. scholarship from the Indonesia Endowment Fund for Education or LPDP to conduct all studies in this book.

Copyright ©Sofa Dewi Alfian, Groningen 2020.

All rights reserved. No part of this thesis may be produced or transmitted in any from or by any means, electronic or mechanical, including photocopying, recording, or by any information storage or retrieval system, without written permission of author. The copyright of previously published chapters of this thesis remains with the publisher or journal.

Adherence to antihypertensive or

antihyperlipidemic co-medications

in diabetes: patterns, predictors,

and intervention

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. C. Wijmenga

and in accordance with the decision by the College of Deans. This thesis will be defended in public on

Tuesday 6 October 2020 at 9.00 hours by

Sofa Dewi Alfian

Supervisors

Assessment Committee

Paranymphs:

TABLE OF CONTENTS

Chapter 1 General Introduction 9

PART I Non-adherence and non-persistence to cardiometabolic medications in

patients with type 2 diabetes: pharmacy data measurement

Chapter 2 A systematic review finds inconsistency in the measures used to

estimate adherence and persistence to multiple cardiometabolic medications

19

Chapter 3 Pharmacy-based predictors of non-adherence, non-persistence and

reinitiation of antihypertensive drugs among patients on oral diabetes drugs in the Netherlands

57

Chapter 4 Pharmacy-based predictors of non-persistence and non-adherence to

statin treatment among patients on oral diabetes medication in the Netherlands

81

PART II Developing and testing a targeted and tailored pharmacist-led

intervention to improve adherence to antihypertensive medications among patients with type 2 diabetes in Indonesia

Chapter 5 Modifiable factors associated with non-adherence to antihypertensive

or antihyperlipidemic drugs are dissimilar: a multicentre study among patients with diabetes in Indonesia

105

Chapter 6 Targeted and tailored pharmacist-led intervention to improve

adherence to antihypertensive drugs among patients with type 2 diabetes in Indonesia: study protocol of a cluster randomised controlled trial

125

Chapter 7 Effectiveness of a targeted and tailored pharmacist-led intervention to

improve adherence to antihypertensive drugs among patients with type 2 diabetes in Indonesia: a cluster randomised controlled trial

157

Chapter 8 Process evaluation of implementing a targeted and tailored

pharmacist-led intervention to improve adherence to antihypertensive drugs among patients with type 2 diabetes in Indonesian Community Health Centres

185

Chapter 9 General Discussion 201

Addendum Summary

Nederlandse Samenvatting

Acknowledgements About the Author PhD Portfolio 218 220 222 226 227