University of Groningen An evaluation of colorectal diseases: surgical aspects and new insights into the mechanisms of fecal continence Jonker, Jara

University of Groningen

An evaluation of colorectal diseases: surgical aspects and new insights into the mechanisms

of fecal continence

Jonker, Jara

DOI:

10.33612/diss.131938980

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Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Jonker, J. (2020). An evaluation of colorectal diseases: surgical aspects and new insights into the mechanisms of fecal continence. University of Groningen. https://doi.org/10.33612/diss.131938980

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Jara Jonker

An Evaluation of

Colorectal Diseases

Surgical Aspects and New Insights into

the Mechanisms of Fecal Continence

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Colofon

An Evaluation of Colorectal Diseases: Surgical Aspects and New Insights into the Mechanisms of Fecal Continence

Jara Jonker

ISBN: 978-94-034-2875-8 (book) ISBN: 978-94-034-2876-5 (ebook) Copyright © 2020 Jara Jonker

All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any way or by any means without the prior permission of the author, or when applicable, of the publishers of the scientific papers.

The printing of this thesis was financially supported by the University of Groningen, University Medical Center Groningen, Graduate School of Medical Sciences, Norgine BV, Laborie / Medical Measurements Systems BV, ChipSoft and Noord Negentig.

Cover design by Annelie Musters

Layout and design by Birgit Vredenburg, persoonlijkproefschrift.nl Printing: Ridderprint | www.ridderprint.nl

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Promotor

Copromotor

Beoordelingscommissie

Prof. dr. R.K. Weersma Prof. dr. T. Wester

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Paranimfen

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TABLE OF CONTENTS

1. General introduction and aims of the thesis 9

Part I Fecal continence mechanisms 29

2. The puborectal continence reflex: a new regulatory mechanism controlling fecal continence

International Journal of Colorectal Disease 2018

31

3. Fecal continence for solid and liquid stool: the function of the anal-external sphincter continence reflex and the puborectal continence reflex

Diseases of the Colon and Rectum (accepted for publication)

45

4. The puborectal continence reflex functions independently of the pudendal nerve

Colorectal Disease 2019

59

Part II Evaluation of colorectal diseases 73 5. Underdiagnosis of mild congenital anorectal malformations

The Journal of Pediatrics 2017

75 6. Congenital anorectal malformation severity does not predict severity

of congenital heart defects The Journal of Pediatrics 2016

85

7. New insights into the treatment of fecal incontinence in patients with congenital anorectal malformations

Submitted

97

8. Fecal continence outcomes are associated with the type, height, and stage procedure of ileal pouch-anal anastomosis

International Journal of Colorectal Disease 2020 (online ahead of print) 113

9. General discussion and future perspectives 131

10. Summary and conclusions 143

11. Nederlandse samenvatting en conclusies 149 Appendices

Abbreviations

List of contributing authors

The Groningen DeFeC Questionnaire List of scientific presentations Dankwoord

Over de auteur

161

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