• No results found

Cover Page The handle http://hdl.handle.net/1887/62059 holds various files of this Leiden University dissertation Author: Majoor, Bas Title: Fibrous dysplasia Date: 2018-04-25

N/A
N/A
Protected

Academic year: 2021

Share "Cover Page The handle http://hdl.handle.net/1887/62059 holds various files of this Leiden University dissertation Author: Majoor, Bas Title: Fibrous dysplasia Date: 2018-04-25"

Copied!
2
0
0

Hele tekst

(1)

Cover Page

The handle http://hdl.handle.net/1887/62059 holds various files of this Leiden University dissertation

Author: Majoor, Bas

Title: Fibrous dysplasia

Date: 2018-04-25

(2)

Stellingen

behorende bij het proefschrift

Fibrous Dysplasia

Bas Majoor, 25 april 2018

1. The wide range of possible GNAS-induced extraskeletal manifestations, compel us to look at fibrous dysplasia as a systemic disease, the care of which requires a multidisciplinary approach. (This thesis)

2. Women with fibrous dysplasia have an increased risk of developing breast cancer, particu- larly in the presence of thoracic FD lesions. (This thesis)

3. Adequate patient selection and an individually-tailored approach are advocated in the surgical management of fibrous dysplasia. (This thesis)

4. Stabilizing interventions in fibrous dysplasia have superior outcomes when bridging the whole length of the lesion. (This thesis)

5. Treatment with bisphosphonates and denosumab hold promising results in the manage- ment of selected FD patient groups. (This thesis)

6. Quality of life and daily functional activities may be significantly impaired in patients with fibrous dysplasia, also in those with monostotic disease. (This thesis)

7. The McCune-Albright syndrome is a potential in vivo model of the role of Gs signalling pathways in biological systems and human disease. (Weinstein, NEJM, 1991)

8. Currently available medical and surgical therapies for fibrous dysplasia are not satisfactory.

(M.T. Collins, Primer on the metabolic bone diseases, 2012)

9. Should cure of FD become feasible in the future, it will be, by default, through innovative approaches. (Riminucci, JBMR, 2006)

10. Fibreuze dysplasie is een slopende ziekte. (Sam)

11. Every time I see an adult on a bicycle, I no longer despair for the future of the human race.

(H.G. Wells, 1866–1946)

12. You should never, never doubt something that no one is sure of. (Roald Dahl’s Willy Wonka, Charlie and the Chocolate Factory, 1964)

13. Kleine operaties bestaan niet, enkel kleine operateurs. (Anoniem)

14. De statistische toetsingstheorie gaat ook buiten wetenschappelijk onderzoek op. Tenzij ontegenzeggelijk is bewezen dat iets onmogelijk is, is alles mogelijk.

stellingen_bas_majoor.indd 1 14-3-2018 12:56:11

Referenties

GERELATEERDE DOCUMENTEN

1. The wide range of possible GNAS-induced extraskeletal manifestations, compel us to look at fibrous dysplasia as a systemic disease, the care of which requires a multidisciplinary

The research described in this thesis was kindly supported by a grant for research into Fibrous Dysplasia by the Bontius Foundation.. Publication of this thesis was kindly supported

The aim of this thesis is to address some of the gaps in our knowledge about the clinical course of fibrous dysplasia, explore some of its additional extraskeletal

[r]

Our data demonstrate that although the more severe types of FD (PFD/MAS) are predictive for presence and severity of pain, these are also determined by the localization of the

In conclusion, data from our cross-sectional study demonstrate impairments in all SF-36 domains of quality of life except for the Mental health and Role emotional domains in

Compared to patients with chronic pain, patients with FD attributed less of their symptoms to their disease (p < 0.001) and perceived more chronicity (p < 0.01) and

[r]

In patients identified as having Mazabraud syndrome, data was retrieved from hospital medical records on age, gender, type of fibrous dysplasia, age at diagnosis of fibrous

30,31 The prevalence of GNAS-mutations in the breast cancer tissue of fibrous dysplasia patients and the association between breast cancer and thoracic localization of FD

Potential risk factors for revision surgery were also assessed, including gender, age at the time of surgery, a preoperative fracture, proximal and distal anchoring of the graft

The second patient who needed revision surgery (ID 12) was a male with a fracture through a fibrous dysplasia lesion of the proximal femur who was treated with a correction

Purposes: In this retrospective study we evaluated (1) the clinical characteristics of FD of the humerus; (2) risk factors for pathological fractures; and (3) outcomes of

paralleled the normalization of bone turnover, and interestingly a beneficial effect on reducing pain symptoms was also observed in MAS patients with extensive skeletal disease

The graphs clearly show an increase in ALP and P1NP levels after 3 months in the group with 6-monthly treatment with bone turnover returning to pre-treatment levels (ALP) or

Fibrous dysplasia (FD) is a rare and ubiquitous disorder, with a very wide clinical spectrum, not only related to the different distribution and evolution of skeletal lesions

• Long-term bisphosphonate therapy is associated with beneficial and safe out- comes in the majority of patients with polyostotic fibrous dysplasia, although response to therapy

Op basis van de opvallende combinatie van pubertas praecox, café-au-lait-vlekken en de uitgebreide distributie van afwijkingen die bij FD pasten, werd de

In Hoofdstuk 11 hebben we daarom gekeken naar de resultaten van behandeling met denosumab, een monoklonaal antilichaam voor RANK-L, in 12 patiënten met een incomplete respons

Heel veel dank voor jouw niet aflatende interesse en hulp bij mijn onderzoek, ondanks jouw eigen drukke schema.. Je kunt ontzettend trots op jezelf zijn, dat ben

In a recent study from the LUMC Center for Bone Quality, it was shown that patients with fibrous dysplasia (FD), particularly those patients with bone pain, reported significant

A case series from our Centre, published as an abstract, demonstrates a positive outcome of treatment with denosumab in 12 adult patients with polyostotic FD/MAS with persistent

Incorporating the assessment of coping strategies and QoL in care pathways for FD/MAS patients is important in tackling not only disease- related outcome but also