The role of ATF2 in insulin action
Baan, B.
Citation
Baan, B. (2009, June 23). The role of ATF2 in insulin action. Retrieved from https://hdl.handle.net/1887/13861
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13861
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The role of ATF2 in insulin action
The role of ATF2 in insulin action
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 23 juni 2009 klokke 11.15 uur
door
Bart Baan
geboren te Leiden
in 1977
Promotiecommissie
Promotores: Prof. dr. J.A. Maassen
Prof. dr. P. ten Dijke
Co-promoter: Dr. D.M. Ouwens
Overige leden: Prof. dr. B. van de Water
Prof. dr. A.K. Raap
Dr. E. Kalkhoven (Universiteit Utrecht)
ISBN: 978-94-901-2235-5
The research described in this thesis was performed at the department of Molecular Cell Biology, Leiden University Medical Centre, the Netherlands. This work was supported by a grant of the Dutch Diabetes Research Foundation.
Printing of this thesis was financially supported by the Dutch Diabetes Research Foundation and the J.E. Jurriaanse Stichting.
This thesis was printed by Gildeprint Drukkerijen, Enschede.
Table of contents
Chapter 1 Introduction and Outline of the thesis 7
Chapter 2 ATF2, a novel player in insulin action and insulin resistance? 17
Chapter 3 The nuclear appearance of ERK and p38 determines the sequential 37 induction of ATF2-Thr71 and ATF2-Thr69-phosphorylation by
serum in JNK-deficient cells
Chapter 4 The role of JNK, p38 and ERK MAP-kinases in insulin-induced 49 Thr69 and Thr71-phosphorylation of transcription factor ATF2
Chapter 5 Identification of insulin-regulated ATF2-target genes in 3T3L1 69 adipocytes and A14 fibroblasts
Chapter 6 Increased in vivo phosphorylation of ATF2 by insulin and 85 high fat diet-induced insulin resistance in mice
Chapter 7 Summary and Discussion 101
Chapter 8 Nederlandse Samenvatting 111
Curriculum vitae 117
List of Publications 119
Appendix Full-colour Illustrations 121
