The handle http://hdl.handle.net/1887/82484 holds various files of this Leiden University
dissertation.
Author: Swets, M.
Biomarkers in colorectal cancer
© M. Swets, 2020, Leiden, the Netherlands. All rights reserved. No parts of this thesis may be reproduced, distributed, stored in a retrieval system or transmitted in any forms or by any means without prior written permission of the author
Biomarkers in colorectal cancer
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 7 januari 2020
klokke 16:15 uur
door
Marloes Swets
Prof. dr. H.J.T. Rutten (UMC Maastricht)
TABLE OF CONTENTS
Chapter 1. General introduction and thesis outline
Part I: Adjuvant chemotherapy in rectal cancer treatment
Chapter 2. Adjuvant chemotherapy after preoperative (chemo) radiotherapy and surgery for patients with rectal cancer: a systematic review and meta-analysis of individual patient data Chapter 3. Should rectal cancer located 10-15cm from the anal verge be
defined as colon cancer
Chapter 4. Are pathological high risk features in locally advanced rectal cancer a useful selection tool for adjuvant chemotherapy?
Part II: Tumour immune interactions, HLA-G expression in colorectal cancer
Chapter 5. HLA-G and classical HLA class I expression in primary colorectal cancer and associated liver metastases
Chapter 6. Promoter methylation and mRNA expression of HLA-G in relation to HLA-G protein expression in colorectal cancer Chapter 7. HLA-G protein expression in colorectal cancer evaluated by
immunohistochemistry and western blot analysis: its expression characteristics remain enigmatic
Part III: Genetic and epigenetic biomarkers in colorectal cancer
Chapter 8. Tumor LINE-1 methylation level in association with survival of patients with stage II colon cancer
Chapter 9. No effect of microsatellite status on outcome of rectal cancer Chapter 10. Summary and Discussion
