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University of Groningen

An orchestra in need of a conductor

Doesburg, Frank

DOI:

10.33612/diss.165632361

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Doesburg, F. (2021). An orchestra in need of a conductor: challenges and opportunities in multi-infusion therapy. University of Groningen. https://doi.org/10.33612/diss.165632361

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An orchestra in need of a conductor

Challenges and opportunities in multi-infusion therapy

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Paranimfen

Dr. L. Zwakman-Hessels L. Reinke, MSc.

Cover Design: Stefan Sloot Layout: Frank Doesburg

Financial support for the publication of this thesis by the following organizations is greatly appreciated:

- Fresenius Kabi

- Stichting KNMP Fondsen

- University Medical Center Groningen, Graduate School of Medical Sciences © Copyright 2021 F. Doesburg

All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior written permis-sion from the author, or when appropriate, from the publishers of the publications included in this thesis.

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An orchestra in need of a conductor

Challenges and opportunities in multi-infusion therapy

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op woensdag 19 mei 2021 om 16:15 uur

door

Frank Doesburg

geboren op 5 december 1988 te Tietjerksteradeel

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Promotores Dr. M.W.N. Nijsten Prof. dr. D.J. Touw Copromotor Dr. W. Bult Beoordelingscommissie Prof. dr. A.F. Bos

Prof. dr. M.M.R.F. Struys Prof. dr. E.L. Swart

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Table of contents

Chapter 1 General introduction 9

Chapter 2 Use of infrared thermography in the detection of superficial phlebitis in adult intensive care unit patients: A prospective single-center observational study

17

Chapter 3A A survey of practices related to drug monographs

in parenteral drug guides in the Netherlands 31 Chapter 3B A systematic procedure for Y-site compatibility

analysis of intravenous drugs used in the intensive care unit

47

Chapter 4 Quantitative assessment of required separator fluid

volume in multi-infusion settings 65 Chapter 5 Improved usability of a multi-infusion setup using a

centralized control interface: A task-based usability test

81

Chapter 6 Towards more efficient use of intravenous lumens in multi-infusion settings: Development and evaluation of a multiplex infusion scheduling algorithm

95

Chapter 7 Multi-infusion with integrated multiple pressure

sensing allows earlier detection of line occlusions 117 Chapter 8 Summary and general discussion 133

Future perspectives 137

Chapter 9 Nederlandse samenvatting 141

List of definitions 145

List of abbreviations 147

List of publications 149

About the author 151

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