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CETP and Inflammation in lipid metabolism and atherosclerosis Vries-van der Weij, A.J. de

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CETP and Inflammation in lipid metabolism and atherosclerosis

Vries-van der Weij, A.J. de

Citation

Vries-van der Weij, A. J. de. (2010, February 3). CETP and Inflammation in lipid metabolism and atherosclerosis. Retrieved from https://hdl.handle.net/1887/14651

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/14651

Note: To cite this publication please use the final published version (if applicable).

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ƒ† ϐŽƒƒ–‹‘

‹‹’‹†‡–ƒ„‘Ž‹•ƒ†–Š‡”‘•…Ž‡”‘•‹•

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ƒ† ϐŽƒƒ–‹‘

‹‹’‹†‡–ƒ„‘Ž‹•ƒ†–Š‡”‘•…Ž‡”‘•‹•





   

–‡”˜‡””‹Œ‰‹‰˜ƒ

†‡‰”ƒƒ†˜ƒ‘…–‘”ƒƒ†‡‹˜‡”•‹–‡‹–‡‹†‡ǡ

‘’‰‡œƒ‰˜ƒ‡…–‘”ƒ‰‹ϐ‹…—•’”‘ˆǤ”ǤǤ Ǥ˜ƒ†‡” ‡‹Œ†‡ǡ

˜‘Ž‰‡•„‡•Ž—‹–˜ƒŠ‡–‘ŽŽ‡‰‡˜‘‘””‘‘–‹‡•

–‡˜‡”†‡†‹‰‡‘’™‘‡•†ƒ‰͵ˆ‡„”—ƒ”‹ʹͲͳͲ

Ž‘‡ͳͷǤͲͲ——”

†‘‘”

‡––‡ ‡••‹…ƒ˜ƒ†‡”‡‹Œ

‰‡„‘”‡–‡Š—‹œ‡

‹ͳͻͺʹ



(5)

”‘‘–‹‡…‘‹••‹‡

”‘‘–‘”‡•ǣ  ”‘ˆǤ”ǤǤǤ ƒ˜‡‡•

   ”‘ˆǤ”ǤǤǤ ”ƒ–•

‘Ǧ”‘‘–‘”‡•ǣ ”ǤǤ‘‘‹•–”ƒ

   ”ǤǤǤǤ‡•‡

  

˜‡”‹‰‡Ž‡†‡ǣ ”ǤǤǤǤ–”‘‡•ȋǡ•–‡”†ƒȌ

   ”ǤǤŽ‡‡ƒȋǡ‡‹†‡Ȍ

   ”‘ˆǤ”ǤǤ Ǥ˜ƒ‡

   ”‘ˆǤ”Ǥ ǤǤ‘‹Œ

     

 

 

 

Š‡”‡•‡ƒ”…Š†‡•…”‹„‡†‹–Š‹•–Š‡•‹•™ƒ••—’’‘”–‡†„›ƒ‰”ƒ–‘ˆ–Š‡‡–‡”ˆ‘”

‡†‹…ƒŽ›•–‡•‹‘Ž‘‰›ȋͳͳͷȌǤ

Š‡•–—†‹‡•’”‡•‡–‡†‹–Š‹•–Š‡•‹•™‡”‡’‡”ˆ‘”‡†ƒ––Š‡ƒ—„‹—•ƒ„‘”ƒ–‘”›ǡ

—ƒŽ‹–›‘ˆ‹ˆ‡ǡ‡‹†‡ǡŠ‡‡–Š‡”Žƒ†•ƒ†ƒ––Š‡‡’ƒ”–‡–‘ˆ†‘…”‹‘Ž‘‰›ǡ

‡‹†‡‹˜‡”•‹–›‡†‹…ƒŽ‡–‡”ǡ‡‹†‡ǡŠ‡‡–Š‡”Žƒ†•Ǥ

‹ƒ…‹ƒŽ•—’’‘”–„›–Š‡‡–Š‡”Žƒ†• ‡ƒ”– ‘—†ƒ–‹‘ˆ‘”–Š‡’—„Ž‹…ƒ–‹‘‘ˆ–Š‹•

–Š‡•‹•‹•‰”ƒ–‡ˆ—ŽŽ›ƒ…‘™Ž‡†‰‡†Ǥ

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‘Ž‘’Š‘

̹Ǥ Ǥ†‡”‹‡•Ǧ˜ƒ†‡”‡‹ŒǡʹͲͳͲǤŽŽ”‹‰Š–•”‡•‡”˜‡†Ǥ‘’ƒ”–‘ˆ–Š‹•’—„Ž‹…ƒ–‹‘ƒ›

„‡”‡’”‘†—…‡†‘”–”ƒ•‹––‡†‹ƒ›ˆ‘”‘”„›ƒ›‡ƒǡ™‹–Š‘—––Š‡’”‹‘”™”‹––‡

’‡”‹••‹‘‘ˆ–Š‡ƒ—–Š‘”Ǥ

 ǣ

ͻ͹ͺͻͶͻͲͳʹʹͻͷͻ

‘˜‡”‹ŽŽ—•–”ƒ–‹‘ǣ

̹‹–‘…’Š‘–‘Ȁ ƒ‹‡–”—•œƒ

”‹–‡†„›

‹Ž†‡’”‹–”—‡”‹Œ‡ǡ•…Š‡†‡



Š‡’”‹–‹‰‘ˆ–Š‹•–Š‡•‹•™ƒ•‹†Ž›•—’’‘”–‡†„›ǣ

•–”ƒ‡‡…ƒǤǤ   ‹‘–”‘‹‡†‡”Žƒ†ǤǤ 

‡–‡”ˆ‘”‡†‹…ƒŽ›•–‡•‹‘Ž‘‰›ȋȌ ƒƒ”ƒƒ• —†  

—–…Š–Š‡”‘•…Ž‡”‘•‹•‘…‹‡–›   Žƒš‘‹–ŠŽ‹‡ǤǤ

ǤǤ —”‹ƒƒ•‡–‹…Š–‹‰   ‡”…Šƒ”’Ƭ‘Š‡ǤǤ 

‘…Š‡‡†‡”Žƒ†ǤǤ   ƒ‘ϐ‹Ǧ˜‡–‹•‡†‡”Žƒ†ǤǤ 

‡”˜‹‡”‡†‡”Žƒ† ƒ”ƒǤǤ   ‡„—Ǧ‹‘



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ƒ„Ž‡‘ˆ…‘–‡–•

Šƒ’–‡”ͳ

‡‡”ƒŽ –”‘†—…–‹‘

Šƒ’–‡”ʹ

‹‰Š …Š‘Ž‡•–‡”‘Ž ˆ‡‡†‹‰ ‹†—…‡• Š‡’ƒ–‹… ‹ϐŽƒƒ–‹‘ –Š”‘—‰Š †‹•–—”„‡†

…Š‘Ž‡•–‡”‘ŽŠ‘‡‘•–ƒ•‹•‹ȗ͵Ǧ‡‹†‡‹…‡

—„‹––‡†

Šƒ’–‡”͵ 

‘„‹‡† •—’’”‡••‹‘ ‘ˆ  ǦɈ ƒ…–‹˜‹–› ƒ† …Š‘Ž‡•–‡”‘Ž Ž‘™‡”‹‰ „›

•ƒŽ‹…›Žƒ–‡‹†—…‡•”‡‰”‡••‹‘‘ˆ’”‡Ǧ‡š‹•–‹‰ƒ–Š‡”‘•…Ž‡”‘–‹…Ž‡•‹‘•„‡›‘†

…Š‘Ž‡•–‡”‘ŽŽ‘™‡”‹‰ƒŽ‘‡

—„‹––‡†

Šƒ’–‡”Ͷ 

ƒ‰‘‹•–•—’’”‡••‡•ƒ–Š‡”‘•…Ž‡”‘–‹…Ž‡•‹‘‰”‘™–Šƒ†’”‘‘–‡•Ž‡•‹‘

”‡‰”‡••‹‘‹’‘ȗ͵Ǧ‡‹†‡‹…‡ǣ–‹‡…‘—”•‡ƒ†’‘–‡–‹ƒŽ‡…Šƒ‹••

‘—”ƒŽ‘ˆ‹’‹†‡•‡ƒ”…Š͸ͶͶͿǢͻͶǣ͹ͶͷǦ͹ͷͷ

Šƒ’–‡”ͷ

‘”…‡–”ƒ’‹„†‘‡•‘–”‡†—…‡ƒ–Š‡”‘•…Ž‡”‘•‹•„‡›‘†ƒ–‘”˜ƒ•–ƒ–‹ƒ†‹†—…‡•

‘”‡’”‘Ǧ‹ϐŽƒƒ–‘”›Ž‡•‹‘•–Šƒƒ–‘”˜ƒ•–ƒ–‹

‹”…—Žƒ–‹‘͸ͶͶ;Ǣͷͷͽǣ͸ͻͷͻǦ͸ͻ͸͸

Šƒ’–‡”͸

—ƒ  ƒ‰‰”ƒ˜ƒ–‡• ƒ–Š‡”‘•…Ž‡”‘•‹• „› ‹…”‡ƒ•‹‰ Ǧ…Š‘Ž‡•–‡”‘Ž

”ƒ–Š‡”–Šƒ„›†‡…”‡ƒ•‹‰ Ǧ…Š‘Ž‡•–‡”‘Ž‹ȗ͵Ǧ‡‹†‡‹…‡

–Š‡”‘•…Ž‡”‘•‹•͸ͶͶͿǢ͸Ͷͼǣͷͻ͹Ǧͷͻ;

Šƒ’–‡”͹ 

‡šƒ”‘–‡‡ ‹†—…‡• †›•Ž‹’‹†‡‹ƒ „› ‹…”‡ƒ•‡†  ’”‘†—…–‹‘ ƒ†

…Š‘Ž‡•–‡”›Ž‡•–‡”–”ƒ•ˆ‡”’”‘–‡‹ȋȌǦ‡†‹ƒ–‡†”‡†—…–‹‘‘ˆ 

†‘…”‹‘Ž‘‰›͸ͶͶͿǢͷͻͶǣ͸͹ͼ;Ǧ͸͹ͽͻ

Šƒ’–‡”ͺ 

‡‡”ƒŽ‹•…—••‹‘

—ƒ”›

‡†‡”Žƒ†•‡•ƒ‡˜ƒ––‹‰˜‘‘”‹‡–Ǧ‹‰‡™‹Œ†‡

‹•–‘ˆ’—„Ž‹…ƒ–‹‘•

—””‹…—Ž—‹–ƒ‡

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