Cover Page
The handle http://hdl.handle.net/1887/37413 holds various files of this Leiden University dissertation
Author: Piers, S.R.D.
Title: Understanding ventricular tachycardia : towards individualized substrate-based therapy
Issue Date: 2016-01-28
S.R.D. PIERS
Understanding
Ventricular Tachycardia:
Towards Individualized Substrate-based
Therapy
Understanding Ventricular Tachycardia:Towards Individualized Substrate-based TherapyS.R.D. PIERS
Understanding Ventricular Tachycardia:
Towards Individualized Substrate-based Therapy
S.R.D. Piers
Understanding Ventricular Tachycardia:
Towards Individualized Substrate-based Therapy S.R.D. Piers
Thesis Leiden University, Faculty of Medicine, with summary in Dutch
Proefschrift Universiteit Leiden, faculteit Geneeskunde, met een samenvatting in het Nederlands
Copyright © S.R.D. Piers 2015
All right reserved. No parts of this thesis may be reproduced, stored in a retrieval sys- tem of any nature or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission of the author, or when appropriate, the publishers of the papers.
ISBN: 978-94-6169-791-2
Lay-out and printed by: Optima Grafische Communicatie, Rotterdam, the Netherlands.
The printing of this thesis was financially supported by St. Jude Medical, Biotronik, Bayer HealthCare, Sanofi Aventis, Chipsoft, Medis Medical Imaging and Toshiba Medical Systems.
Understanding Ventricular Tachycardia:
Towards Individualized Substrate-based Therapy
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 28 januari 2016
klokke 16:15 uur door
Sebastiaan Roderick Daniël Piers geboren te Utrecht
in 1986
Promotores:
Prof. dr. K. Zeppenfeld Prof. dr. M.J. Schalij
Promotiecommissie:
Prof. dr. J.M.T. de Bakker (Universiteit van Amsterdam) Prof. dr. N.A. Blom
Dr. A. Meijer (Catharina Ziekenhuis, Eindhoven) Prof. dr. L. Mont (Hospital Clinic, Barcelona) Dr. D.A. Pijnappels
Dr. Q. Tao
Het verschijnen van dit proefschrift werd mede mogelijk gemaakt door de steun van de Nederlandse Hartstichting en de Stichting Wetenschap en Onderzoek Interne Ge- neeskunde Onze Lieve Vrouwe Gasthuis.
ConTenTS
Chapter 1 General introduction and outline of thesis 9
Part I Imaging-guided VT ablation
Chapter 2 Imaging-guided ventricular tachycardia ablation Piers SRD, Zeppenfeld K
Arrhythmia & Electrophysiology Review 2013;2(2):128-34
27
Chapter 3 epicardial substrate mapping for ventricular tachycardia ablation in patients with non-ischemic cardiomyopathy:
a new algorithm to differentiate between scar and viable myocardium developed by simultaneous integration of computed tomography and contrast-enhanced magnetic resonance imaging
Piers SRD, van Huls van Taxis CF, Tao Q, van der Geest RJ, Askar SF, Siebelink HM, Schalij MJ, Zeppenfeld K
European Heart Journal 2013;34(8):586-96
49
Chapter 4 Contrast-enhanced MRI-derived scar patterns and associated ventricular tachycardias in nonischemic cardiomyopathy:
implications for the ablation strategy
Piers SRD, Tao Q, van Huls van Taxis CF, Schalij MJ, van der Geest RJ, Zeppenfeld K Circulation: Arrhythmia & Electrophysiology 2013;6(5):875-83
71
Chapter 5 CMR-based identification of critical isthmus sites of ischemic and nonischemic ventricular tachycardia
Piers SRD, Tao Q, de Riva Silva M, Siebelink HM, Schalij MJ, van der Geest RJ, Zeppenfeld K
JACC: Cardiovascular Imaging 2014;7(8):774-84
91
Part II From Substrate and VT Features to Therapy and Outcome
Chapter 6 endocardial or epicardial ventricular tachycardia in nonischemic cardiomyopathy:
The role of 12-lead eCG criteria in clinical practice Piers SRD, de Riva Silva M, Kapel GF, Trines SA, Schalij MJ, Zeppenfeld K Heart Rhythm 2014;11(6):1031-9
115
Chapter 7 Influence of steroid therapy on the incidence of pericarditis and atrial fibrillation after percutaneous epicardial mapping and ablation for ventricular tachycardia
Piers SRD, Dyrda K, van Huls van Taxis CF, Schalij MJ, Zeppenfeld K Circulation: Arrhythmia & Electrophysiology 2014;7(4):671-6
135
Chapter 8 outcomes of ventricular tachycardia ablation in patients with nonischemic cardiomyopathy: the impact of noninducibility Piers SRD, Leong DP, van Taxis CF, Tayyebi M, Trines SA, Pijnappels DA, Delgado V, Schalij MJ, Zeppenfeld K
Circulation: Arrhythmia & Electrophysiology 2013;6(3):513-21
149
Chapter 9 early reperfusion therapy affects inducibility, cycle length and occurrence of ventricular tachycardia late after myocardial infarction
Piers SRD, Wijnmaalen AP, Borleffs CJ, van Huls van Taxis CF, Thijssen J, van Rees JB, Cannegieter SC, Bax JJ, Schalij MJ, Zeppenfeld K
Circulation: Arrhythmia & Electrophysiology 2011;4(2):195-201
171
Chapter 10 Myocardial scar predicts monomorphic VT but not polymorphic VT or VF in non-ischemic dilated cardiomyopathy
Piers SRD, Everaerts K, van der Geest RJ, Hazebroek MR, Siebelink HM, Pison LAFG, Schalij MJ, Bekkers SCAM, Heymans S, Zeppenfeld K
Heart Rhythm 2015;12(10):2106-14
189
Chapter 11 Critical QRS prolongation after premature stimulation is associated with polymorphic ventricular tachycardia in nonischemic cardiomyopathy: results from the Leiden nonischemic Cardiomyopathy Study
Piers SRD, Askar SFA, Venlet J, Kapel GFL, de Riva Silva M, Jongbloed JJDH, van Tintelen JP, Schalij MJ, Pijnappels DA, Zeppenfeld K
Accepted for publication in Heart Rhythm
213
Chapter 12 Summary, conclusions and future perspectives:
Towards more effective, individualized substrate-based therapies for ventricular arrhythmias.
237
nederlandse samenvatting 249
Dankwoord 255
List of publications 257
Curriculum vitae 263
